ID   GPHR_CHICK              Reviewed;         455 AA.
AC   Q5F448;
DT   07-FEB-2006, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2005, sequence version 1.
DT   03-AUG-2022, entry version 94.
DE   RecName: Full=Golgi pH regulator;
DE   AltName: Full=Protein GPR89;
GN   Name=GPR89; Synonyms=GPHR; ORFNames=RCJMB04_3g11;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=CB; TISSUE=Bursa of Fabricius;
RX   PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA   Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA   Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA   Hayashizaki Y., Buerstedde J.-M.;
RT   "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT   function analysis.";
RL   Genome Biol. 6:R6.1-R6.9(2005).
CC   -!- FUNCTION: Voltage dependent anion channel required for acidification
CC       and functions of the Golgi apparatus that may function in counter-ion
CC       conductance (By similarity). Plays a role in lymphocyte development (By
CC       similarity). {ECO:0000250|UniProtKB:B2ZXD5,
CC       ECO:0000250|UniProtKB:Q8BS95}.
CC   -!- SUBUNIT: Homotrimer. {ECO:0000250|UniProtKB:B7ZAQ6}.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus membrane
CC       {ECO:0000250|UniProtKB:B2ZXD5}; Multi-pass membrane protein
CC       {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the Golgi pH regulator (TC 1.A.38) family.
CC       {ECO:0000305}.
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DR   EMBL; AJ851452; CAH65086.1; -; mRNA.
DR   RefSeq; NP_001025962.1; NM_001030791.1.
DR   AlphaFoldDB; Q5F448; -.
DR   SMR; Q5F448; -.
DR   STRING; 9031.ENSGALP00000024938; -.
DR   PaxDb; Q5F448; -.
DR   Ensembl; ENSGALT00000024984; ENSGALP00000024938; ENSGALG00000015491.
DR   GeneID; 418459; -.
DR   KEGG; gga:418459; -.
DR   CTD; 653519; -.
DR   VEuPathDB; HostDB:geneid_418459; -.
DR   eggNOG; KOG2417; Eukaryota.
DR   GeneTree; ENSGT00390000000684; -.
DR   HOGENOM; CLU_030540_1_0_1; -.
DR   InParanoid; Q5F448; -.
DR   OMA; HFNFYHR; -.
DR   OrthoDB; 1065554at2759; -.
DR   PhylomeDB; Q5F448; -.
DR   TreeFam; TF313484; -.
DR   PRO; PR:Q5F448; -.
DR   Proteomes; UP000000539; Chromosome 1.
DR   Bgee; ENSGALG00000015491; Expressed in kidney and 13 other tissues.
DR   ExpressionAtlas; Q5F448; baseline and differential.
DR   GO; GO:0032580; C:Golgi cisterna membrane; ISS:UniProtKB.
DR   GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0030660; C:Golgi-associated vesicle membrane; ISS:UniProtKB.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0008308; F:voltage-gated anion channel activity; ISS:UniProtKB.
DR   GO; GO:0051452; P:intracellular pH reduction; ISS:UniProtKB.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR   GO; GO:0043588; P:skin development; IEA:Ensembl.
DR   GO; GO:0030217; P:T cell differentiation; IEA:Ensembl.
DR   InterPro; IPR025969; ABA_GPCR_dom.
DR   InterPro; IPR022535; Golgi_pH-regulator_cons_dom.
DR   InterPro; IPR015672; GPHR/GTG.
DR   PANTHER; PTHR15948; PTHR15948; 1.
DR   Pfam; PF12430; ABA_GPCR; 1.
DR   Pfam; PF12537; GPHR_N; 1.
PE   2: Evidence at transcript level;
KW   Glycoprotein; Golgi apparatus; Ion channel; Ion transport; Membrane;
KW   Protein transport; Reference proteome; Transmembrane; Transmembrane helix;
KW   Transport; Voltage-gated channel.
FT   CHAIN           1..455
FT                   /note="Golgi pH regulator"
FT                   /id="PRO_0000223262"
FT   TRANSMEM        5..25
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        46..66
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        79..99
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        111..131
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        150..170
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        290..310
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        343..363
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        378..398
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        425..445
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        67
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        180
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        243
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   455 AA;  52753 MW;  8E3DDFA2156BCE8F CRC64;
     MSFLIDSSIM VTSQVLFFGF GWLFFMRKLF KDYEVRQYVV QVIFSVTFAF SCTMFELIIF
     EILGVLNSSS RYFHWKLNLC VILLILVFMV PFYIGYFVVS NIRLLHRQKL LFACVLWLTF
     MYFFWKLGDP FPILSPKHGI LSIEQLISRV GVIGVTLMAL LSGFGAVNCP YTYMSYFLRN
     VTDADILALE RRLLQTMDMI ISKKKRIAVA HRTMFQRGEV HNKPTGFWGM IKSVTTSVAG
     SENLSLIQQE VDALEELSRQ LFLETADLHA TKERIEYSKT FQGKYFNFLG YFFSIYCVWK
     IFMATINIVF DRVGKTDPVT RGIEITVNYL GIQFDVKFWS QHISFILVGI IIVTSIRGLL
     ITLTKFFYAI SSSKSSNVIV LLLAQIMGMY FVSSVLLIRM SMPLEYRTII TEVLGELQFN
     FYHRWFDVIF LVSALSSILF LYLAHKQAPE KHMAL