GPHR_DICDI
ID GPHR_DICDI Reviewed; 547 AA.
AC Q54QM5;
DT 16-DEC-2008, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 25-MAY-2022, entry version 74.
DE RecName: Full=Golgi pH regulator homolog;
DE AltName: Full=Protein GPR89;
GN Name=gpr89; Synonyms=gphr; ORFNames=DDB_G0283855;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein.
CC -!- SIMILARITY: Belongs to the Golgi pH regulator (TC 1.A.38) family.
CC {ECO:0000305}.
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DR EMBL; AAFI02000057; EAL65542.1; -; Genomic_DNA.
DR RefSeq; XP_638846.1; XM_633754.1.
DR AlphaFoldDB; Q54QM5; -.
DR SMR; Q54QM5; -.
DR STRING; 44689.DDB0218522; -.
DR PaxDb; Q54QM5; -.
DR PRIDE; Q54QM5; -.
DR EnsemblProtists; EAL65542; EAL65542; DDB_G0283855.
DR GeneID; 8624244; -.
DR KEGG; ddi:DDB_G0283855; -.
DR dictyBase; DDB_G0283855; gpr89.
DR eggNOG; KOG2417; Eukaryota.
DR HOGENOM; CLU_030540_1_0_1; -.
DR InParanoid; Q54QM5; -.
DR OMA; HFNFYHR; -.
DR PhylomeDB; Q54QM5; -.
DR PRO; PR:Q54QM5; -.
DR Proteomes; UP000002195; Chromosome 4.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IDA:dictyBase.
DR GO; GO:0000139; C:Golgi membrane; IDA:dictyBase.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0002020; F:protease binding; IPI:dictyBase.
DR GO; GO:0048870; P:cell motility; IMP:dictyBase.
DR GO; GO:0048388; P:endosomal lumen acidification; IMP:dictyBase.
DR GO; GO:0009306; P:protein secretion; IMP:dictyBase.
DR GO; GO:0010468; P:regulation of gene expression; IMP:dictyBase.
DR GO; GO:0030587; P:sorocarp development; IMP:dictyBase.
DR InterPro; IPR025969; ABA_GPCR_dom.
DR InterPro; IPR022535; Golgi_pH-regulator_cons_dom.
DR InterPro; IPR015672; GPHR/GTG.
DR PANTHER; PTHR15948; PTHR15948; 1.
DR Pfam; PF12430; ABA_GPCR; 1.
DR Pfam; PF12537; GPHR_N; 1.
PE 3: Inferred from homology;
KW Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..547
FT /note="Golgi pH regulator homolog"
FT /id="PRO_0000356840"
FT TRANSMEM 56..76
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 92..112
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 134..154
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 164..184
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 200..220
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 427..447
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 469..489
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 517..537
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 268..305
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 290
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 299
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 547 AA; 64245 MW; 2B95CB8C58A02A07 CRC64;
MDTFTIEEIV KFDGGGGGIS TINSNNDNIG IPSNTFEMII STIQHFLDRS SSVASTIAVF
VLSFILFFMF GWFYFLKILF RDYEVKKVFV QLSFSITFAL SLTLFELIFF EIMDFMDREW
RYRFWEFDLT LMSINLILVL PYYQFYLLVL AYGFSKRKTL FFSLVLLVLY LILFWKIGDP
FPILKEYTGL VSLEMGIGRI GIVGCTVMSL LSGYGAVYVP YSYITYFLKP VKDVTITKLE
KQFNHALDKI FNKKKRVVLL KRELTRRNVN NNNNNNNNYD TYNYNNNYNN NSNNNNNNNN
SNNNNNNNLP IIGPIFSKIY NLWNVGYHHQ LSRPIDDIKQ LEREIKQLED LNRDLFTQIH
ELKLERLRIQ FSTTLRGKFY NWLGYFFSIY WKKKSALNIV FDRRGGMDPV TRGLDIALRY
FHFQVDVTFW SQHISFILVG LMTASSIRGF LNQILKVFHE YSSSLSSNNI VLILAQVMGM
YFISSVLMMR TSMPEIYTRF IVTQILGDIE FSFYHRWFDF IFIPSAIITT LALIFMSKSS
TFHLNDE
