ID   GPHR_SALSA              Reviewed;         455 AA.
AC   B5X1G3;
DT   15-JUN-2010, integrated into UniProtKB/Swiss-Prot.
DT   25-NOV-2008, sequence version 1.
DT   25-MAY-2022, entry version 36.
DE   RecName: Full=Golgi pH regulator;
DE   AltName: Full=Protein gpr89;
GN   Name=gpr89; Synonyms=gphr;
OS   Salmo salar (Atlantic salmon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC   Salmonidae; Salmoninae; Salmo.
OX   NCBI_TaxID=8030;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=20433749; DOI=10.1186/1471-2164-11-279;
RA   Leong J.S., Jantzen S.G., von Schalburg K.R., Cooper G.A., Messmer A.M.,
RA   Liao N.Y., Munro S., Moore R., Holt R.A., Jones S.J., Davidson W.S.,
RA   Koop B.F.;
RT   "Salmo salar and Esox lucius full-length cDNA sequences reveal changes in
RT   evolutionary pressures on a post-tetraploidization genome.";
RL   BMC Genomics 11:279-279(2010).
CC   -!- FUNCTION: Voltage dependent anion channel required for acidification
CC       and functions of the Golgi apparatus that may function in counter-ion
CC       conductance (By similarity). Plays a role in lymphocyte development (By
CC       similarity). {ECO:0000250|UniProtKB:B2ZXD5,
CC       ECO:0000250|UniProtKB:Q8BS95}.
CC   -!- SUBUNIT: Homotrimer. {ECO:0000250|UniProtKB:B7ZAQ6}.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus membrane
CC       {ECO:0000250|UniProtKB:B2ZXD5}; Multi-pass membrane protein
CC       {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the Golgi pH regulator (TC 1.A.38) family.
CC       {ECO:0000305}.
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DR   EMBL; BT044882; ACI33144.1; -; mRNA.
DR   RefSeq; NP_001133391.1; NM_001139919.1.
DR   AlphaFoldDB; B5X1G3; -.
DR   SMR; B5X1G3; -.
DR   GeneID; 100194890; -.
DR   KEGG; sasa:100194890; -.
DR   OrthoDB; 1065554at2759; -.
DR   Proteomes; UP000087266; Chromosome ssa25.
DR   GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005244; F:voltage-gated ion channel activity; IEA:UniProtKB-KW.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR   InterPro; IPR025969; ABA_GPCR_dom.
DR   InterPro; IPR022535; Golgi_pH-regulator_cons_dom.
DR   InterPro; IPR015672; GPHR/GTG.
DR   PANTHER; PTHR15948; PTHR15948; 1.
DR   Pfam; PF12430; ABA_GPCR; 1.
DR   Pfam; PF12537; GPHR_N; 1.
PE   2: Evidence at transcript level;
KW   Glycoprotein; Golgi apparatus; Ion channel; Ion transport; Membrane;
KW   Protein transport; Reference proteome; Transmembrane; Transmembrane helix;
KW   Transport; Voltage-gated channel.
FT   CHAIN           1..455
FT                   /note="Golgi pH regulator"
FT                   /id="PRO_0000395007"
FT   TRANSMEM        46..66
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        79..99
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        111..131
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        150..170
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        290..310
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        343..363
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        378..398
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        425..445
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        180
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        243
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   455 AA;  53102 MW;  9A46A4C30CD07479 CRC64;
     MSFLMDSVIM FTSQVLFFGF GWLFFMRQLF KDYEVRQYVV QVVFSITFAF SCTMFELIIF
     EILGALETSS RYFHWKFNLY VILLVLIFVV PFYIGYFVVS NIRLLQRQKL LFACVVWFTF
     MYFFWKLGDP FPILSPKHGI LSIEQLISRV GVIGVTLMAL LSGFGAVNCP YTYMSYFLRN
     VTESDILALE RRLLQTMDMI VSKKKRIAMT RRQMYQRGED QNKQTGFWGM IKSVTSSPPG
     SENLSLIQQE VDALEELSRQ LFLETVDLQA TKERIEYSKT FQGKYFNFLG YFFSIYCVWK
     IFMATINIVF DRVGKTDPVT RGIEITVNYL GIQFDVKFWS QHISFILVGI IIVTSIRGLL
     ITLTKFFYAI SSSKSSNVIV LVLAQIMGMY FVSSVLLMRM SMPLEYRSIV TEVLGELQFN
     FYHRWFDVIF LVSALSSILF LYLAHKQAPE KHMTP