ID   GPHR_XENLA              Reviewed;         455 AA.
AC   Q6DDW6;
DT   15-JUN-2010, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 65.
DE   RecName: Full=Golgi pH regulator;
DE   AltName: Full=Protein gpr89b;
GN   Name=gpr89-b; Synonyms=gphr;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Voltage dependent anion channel required for acidification
CC       and functions of the Golgi apparatus that may function in counter-ion
CC       conductance (By similarity). Plays a role in lymphocyte development (By
CC       similarity). {ECO:0000250|UniProtKB:B2ZXD5,
CC       ECO:0000250|UniProtKB:Q8BS95}.
CC   -!- SUBUNIT: Homotrimer. {ECO:0000250|UniProtKB:B7ZAQ6}.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus membrane
CC       {ECO:0000250|UniProtKB:B2ZXD5}; Multi-pass membrane protein
CC       {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the Golgi pH regulator (TC 1.A.38) family.
CC       {ECO:0000305}.
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DR   EMBL; BC077386; AAH77386.1; -; mRNA.
DR   RefSeq; NP_001086744.1; NM_001093275.1.
DR   RefSeq; XP_018100612.1; XM_018245123.1.
DR   AlphaFoldDB; Q6DDW6; -.
DR   SMR; Q6DDW6; -.
DR   DNASU; 446579; -.
DR   GeneID; 446579; -.
DR   KEGG; xla:446579; -.
DR   CTD; 446579; -.
DR   Xenbase; XB-GENE-484939; gpr89b.L.
DR   OMA; HFNFYHR; -.
DR   OrthoDB; 1065554at2759; -.
DR   Proteomes; UP000186698; Chromosome 2L.
DR   Bgee; 446579; Expressed in stomach and 19 other tissues.
DR   GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005244; F:voltage-gated ion channel activity; IEA:UniProtKB-KW.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR   InterPro; IPR025969; ABA_GPCR_dom.
DR   InterPro; IPR022535; Golgi_pH-regulator_cons_dom.
DR   InterPro; IPR015672; GPHR/GTG.
DR   PANTHER; PTHR15948; PTHR15948; 1.
DR   Pfam; PF12430; ABA_GPCR; 1.
DR   Pfam; PF12537; GPHR_N; 1.
PE   2: Evidence at transcript level;
KW   Glycoprotein; Golgi apparatus; Ion channel; Ion transport; Membrane;
KW   Protein transport; Reference proteome; Transmembrane; Transmembrane helix;
KW   Transport; Voltage-gated channel.
FT   CHAIN           1..455
FT                   /note="Golgi pH regulator"
FT                   /id="PRO_0000395008"
FT   TRANSMEM        5..25
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        46..66
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        79..99
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        111..131
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        150..170
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        290..310
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        343..363
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        378..398
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        425..445
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        67
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        180
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   455 AA;  52907 MW;  CC69CA6442E2590F CRC64;
     MSFFADSVLM VISQLLFFGF GWLFFMRQLF KDYEVRQYVV QVVFSVTFAF SCTMFELIIF
     EILGLLNSSS RYFHWKLNLC VILLVLVFVV PFYIGYFVVS NIRLLHRQRL LFSCTIWLTF
     MYFFWKLGDP FPILSPKHGI LSIEQLISRV GVIGVTLMAL LSGFGAVNCP YTYMSYFLRN
     VTDADILALE RRLLQTMDMI VSKKKRIAAV RRNMFQRGEE HSKPSGFWGM IKSVTSSAPV
     SENLYQIQQE VDALEELSRQ LFLETADLHA TKERIEYSKT FQGKYFNFLG YFFSIYCVWK
     IFMATINIVF DRVGKTDPVT RGIEITVNYL GIQFDVKFWS QHISFILVGI IIVTSIRGLL
     ITLTKFFYAI SSSKSSNVIV LLLAQIMGMY FVSSVLLIRM SMPLEYRTII TEVLGELQFN
     FYHRWFDVIF LVSALSSILF LYLAHKQAPE KHMAL