GPI10_ASHGO
ID GPI10_ASHGO Reviewed; 595 AA.
AC Q75BG9;
DT 25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 25-MAY-2022, entry version 94.
DE RecName: Full=GPI mannosyltransferase 3;
DE EC=2.4.1.-;
DE AltName: Full=GPI mannosyltransferase III;
DE Short=GPI-MT-III;
DE AltName: Full=Glycosylphosphatidylinositol-anchor biosynthesis protein 10;
GN Name=GPI10; OrderedLocusNames=ADL281C;
OS Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS (Yeast) (Eremothecium gossypii).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX NCBI_TaxID=284811;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX PubMed=15001715; DOI=10.1126/science.1095781;
RA Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA Gaffney T.D., Philippsen P.;
RT "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT cerevisiae genome.";
RL Science 304:304-307(2004).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX PubMed=23749448; DOI=10.1534/g3.112.002881;
RA Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT loci, numerous translocations, lack of transposons, and distinct gene
RT duplications.";
RL G3 (Bethesda) 3:1225-1239(2013).
CC -!- FUNCTION: Mannosyltransferase involved in glycosylphosphatidylinositol-
CC anchor biosynthesis. Transfers the third mannose to Man2-GlcN-acyl-PI
CC during GPI precursor assembly (By similarity). {ECO:0000250}.
CC -!- PATHWAY: Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor
CC biosynthesis.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250};
CC Multi-pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the glycosyltransferase 22 family. PIGB
CC subfamily. {ECO:0000305}.
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DR EMBL; AE016817; AAS51639.1; -; Genomic_DNA.
DR RefSeq; NP_983815.1; NM_209168.1.
DR AlphaFoldDB; Q75BG9; -.
DR STRING; 33169.AAS51639; -.
DR CAZy; GT22; Glycosyltransferase Family 22.
DR EnsemblFungi; AAS51639; AAS51639; AGOS_ADL281C.
DR GeneID; 4619950; -.
DR KEGG; ago:AGOS_ADL281C; -.
DR eggNOG; KOG1771; Eukaryota.
DR HOGENOM; CLU_012353_2_0_1; -.
DR InParanoid; Q75BG9; -.
DR OMA; HEWPDYL; -.
DR UniPathway; UPA00196; -.
DR Proteomes; UP000000591; Chromosome IV.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0000026; F:alpha-1,2-mannosyltransferase activity; IBA:GO_Central.
DR GO; GO:0004376; F:glycolipid mannosyltransferase activity; IEA:InterPro.
DR GO; GO:0000030; F:mannosyltransferase activity; IBA:GO_Central.
DR GO; GO:0006506; P:GPI anchor biosynthetic process; IBA:GO_Central.
DR InterPro; IPR005599; GPI_mannosylTrfase.
DR InterPro; IPR039521; PIG-B/GPI10.
DR PANTHER; PTHR22760; PTHR22760; 1.
DR PANTHER; PTHR22760:SF4; PTHR22760:SF4; 1.
DR Pfam; PF03901; Glyco_transf_22; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum; Glycosyltransferase; GPI-anchor biosynthesis;
KW Membrane; Reference proteome; Transferase; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..595
FT /note="GPI mannosyltransferase 3"
FT /id="PRO_0000246257"
FT TRANSMEM 58..78
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 85..105
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 128..148
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 185..207
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 212..232
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 235..255
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 260..280
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 289..309
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 319..339
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 413..433
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 595 AA; 67312 MW; 8DB50002FC3803E6 CRC64;
MKERSILRTL FLWRLINALS IRSFFQADEY WQSLEPAHVK AFGYGGLTWE WQHGLRSYAF
PMLFEMSYYV AWILGVATRM ALQGLAHATA LCGAVVPSGA AGVAAMKAVW ELPEAAQELV
EYYGVLYGPR VVMAAVAACG EFYSVLLVRK LYLRVADKGD DQKGDAAPVS RLALMLTMTN
FFNCFFATRT FINSFEMTLT AVALYHWDWS GGLDVGSLGF SASLAVAAFA CLQRPTNVLI
WAVLGLFLVL NLVRSRRWQL LLTLVAKVAA AGALAVCANI AIDYYFYGGV LLPLLRFIEF
NVTTPLAAFY GRAPWHFHLL QSVPLIVGYA LPFFVGALLT HNFRRGNAGL LGSPIMQIKC
VVVLNIALYS CIDHKEFRFL YPLQPLFLSL SALEMHTWLQ HHHARGTAWL KRVQSLLYVL
PVLSITAALV LNTAHEAGVV SVMDYLHSAV PSAESIGFIM PCHSTPWQSH LHRNDLGKLW
AISCQPPLDL LHQEDAGDQL LTYMDESDHL YENIPEFIHK NFPPVFRRDL RSPGRQYAYE
WPEFLVVFEH MDEAFMKEYL KDSNYVEVKR FFNTLSHWDS RRAGDVIVYH KSPWY
