ID   GPI18_CHAGB             Reviewed;         471 AA.
AC   Q2GSI6;
DT   25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT   21-MAR-2006, sequence version 1.
DT   25-MAY-2022, entry version 60.
DE   RecName: Full=GPI mannosyltransferase 2;
DE            EC=2.4.1.-;
DE   AltName: Full=GPI mannosyltransferase II;
DE            Short=GPI-MT-II;
DE   AltName: Full=Glycosylphosphatidylinositol-anchor biosynthesis protein 18;
GN   Name=GPI18; ORFNames=CHGG_09068;
OS   Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 /
OS   NRRL 1970) (Soil fungus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Chaetomiaceae; Chaetomium.
OX   NCBI_TaxID=306901;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970;
RX   PubMed=25720678; DOI=10.1128/genomea.00021-15;
RA   Cuomo C.A., Untereiner W.A., Ma L.-J., Grabherr M., Birren B.W.;
RT   "Draft genome sequence of the cellulolytic fungus Chaetomium globosum.";
RL   Genome Announc. 3:E0002115-E0002115(2015).
CC   -!- FUNCTION: Mannosyltransferase involved in glycosylphosphatidylinositol-
CC       anchor biosynthesis. Transfers the second mannose to the
CC       glycosylphosphatidylinositol during GPI precursor assembly (By
CC       similarity). {ECO:0000250}.
CC   -!- PATHWAY: Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor
CC       biosynthesis.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250};
CC       Multi-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the PIGV family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CH408034; EAQ85054.1; -; Genomic_DNA.
DR   RefSeq; XP_001226995.1; XM_001226994.1.
DR   AlphaFoldDB; Q2GSI6; -.
DR   STRING; 38033.XP_001226995.1; -.
DR   EnsemblFungi; EAQ85054; EAQ85054; CHGG_09068.
DR   GeneID; 4395328; -.
DR   eggNOG; KOG2647; Eukaryota.
DR   HOGENOM; CLU_029048_0_0_1; -.
DR   InParanoid; Q2GSI6; -.
DR   OMA; EYFLHIA; -.
DR   OrthoDB; 960696at2759; -.
DR   UniPathway; UPA00196; -.
DR   Proteomes; UP000001056; Unassembled WGS sequence.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0000009; F:alpha-1,6-mannosyltransferase activity; IEA:InterPro.
DR   GO; GO:0004376; F:glycolipid mannosyltransferase activity; IEA:InterPro.
DR   GO; GO:0006506; P:GPI anchor biosynthetic process; IEA:UniProtKB-UniPathway.
DR   InterPro; IPR007315; PIG-V/Gpi18.
DR   PANTHER; PTHR12468; PTHR12468; 1.
DR   Pfam; PF04188; Mannosyl_trans2; 1.
PE   3: Inferred from homology;
KW   Endoplasmic reticulum; Glycosyltransferase; GPI-anchor biosynthesis;
KW   Membrane; Reference proteome; Transferase; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..471
FT                   /note="GPI mannosyltransferase 2"
FT                   /id="PRO_0000246244"
FT   TRANSMEM        23..43
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        135..155
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        169..189
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        190..210
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        227..247
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        277..297
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        348..368
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        449..469
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   471 AA;  50417 MW;  5FE05A32DDC5DEE0 CRC64;
     MAPKHQTPHT HAQIHTHPYR TLLTSFAAWK LFLFAIVLGS TLVGDAYDTS GGLLLQGPAN
     GDAATRPAGL GTTLIARLTS WDAIYYVSAA RRDYVFEQEW AFGAGLPFVV RTLLQGLEYV
     GIIDAPGAEG GRALVAEALA GILVANTAHL LSALVLYRLG QVVWRDQTLS LVAALLHVIS
     PAGLFLSAPY SESSFALLSF SGYLLFALGC RAEGSSNSNN SPTRRDLYTI SAGVLFGAAT
     VFRSNGLLNG APFALEVLRH LPAFVRRPTA IDTLRRLAAL GVGGAAVAAG SLGPQAAAYL
     RYCIPSSSSG ASDGEENLLL PRPWCQGYLP SIFTFVQQHY WNVGFLRYWT LPNLPLFLLA
     TPMLVILVKS GVDSLRGRHL PGDAKAVDGE SGRLLALIRS TAAAQVLLAV LAATTYHVQI
     ITRISSGYPV WHWWLAGRLV QGDKTGSRIV MFMVIYASIQ GALFASFLPP A