GPI3_SCHPO
ID GPI3_SCHPO Reviewed; 456 AA.
AC P87172;
DT 10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-1997, sequence version 1.
DT 25-MAY-2022, entry version 122.
DE RecName: Full=Phosphatidylinositol N-acetylglucosaminyltransferase gpi3 subunit;
DE EC=2.4.1.198;
DE AltName: Full=GlcNAc-PI synthesis protein;
GN Name=gpi3; ORFNames=SPBC3D6.07;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
CC -!- FUNCTION: Catalytic subunit in the complex catalyzing the transfer of
CC N-acetylglucosamine from UDP-N-acetylglucosamine to
CC phosphatidylinositol, the first step of GPI biosynthesis.
CC {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + UDP-N-
CC acetyl-alpha-D-glucosamine = a 6-(N-acetyl-alpha-D-glucosaminyl)-1-
CC phosphatidyl-1D-myo-inositol + H(+) + UDP; Xref=Rhea:RHEA:14789,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:57265, ChEBI:CHEBI:57705,
CC ChEBI:CHEBI:57880, ChEBI:CHEBI:58223; EC=2.4.1.198;
CC -!- PATHWAY: Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor
CC biosynthesis.
CC -!- SUBUNIT: Component of a Phosphatidylinositol N-
CC acetylglucosaminyltransferase complex. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the glycosyltransferase group 1 family.
CC Glycosyltransferase 4 subfamily. {ECO:0000305}.
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DR EMBL; CU329671; CAB09127.1; -; Genomic_DNA.
DR PIR; T40367; T40367.
DR RefSeq; NP_595519.1; NM_001021428.1.
DR AlphaFoldDB; P87172; -.
DR SMR; P87172; -.
DR BioGRID; 277502; 2.
DR STRING; 4896.SPBC3D6.07.1; -.
DR CAZy; GT4; Glycosyltransferase Family 4.
DR iPTMnet; P87172; -.
DR MaxQB; P87172; -.
DR PaxDb; P87172; -.
DR PRIDE; P87172; -.
DR EnsemblFungi; SPBC3D6.07.1; SPBC3D6.07.1:pep; SPBC3D6.07.
DR GeneID; 2540986; -.
DR KEGG; spo:SPBC3D6.07; -.
DR PomBase; SPBC3D6.07; gpi3.
DR VEuPathDB; FungiDB:SPBC3D6.07; -.
DR eggNOG; KOG1111; Eukaryota.
DR HOGENOM; CLU_009583_19_0_1; -.
DR InParanoid; P87172; -.
DR OMA; FFCPNAG; -.
DR PhylomeDB; P87172; -.
DR Reactome; R-SPO-162710; Synthesis of glycosylphosphatidylinositol (GPI).
DR UniPathway; UPA00196; -.
DR PRO; PR:P87172; -.
DR Proteomes; UP000002485; Chromosome II.
DR GO; GO:0000506; C:glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex; ISO:PomBase.
DR GO; GO:0017176; F:phosphatidylinositol N-acetylglucosaminyltransferase activity; IBA:GO_Central.
DR GO; GO:0006506; P:GPI anchor biosynthetic process; ISO:PomBase.
DR CDD; cd03796; GT4_PIG-A-like; 1.
DR InterPro; IPR001296; Glyco_trans_1.
DR InterPro; IPR039507; PIG-A/GPI3.
DR InterPro; IPR013234; PIGA_GPI_anchor_biosynthesis.
DR Pfam; PF00534; Glycos_transf_1; 1.
DR Pfam; PF08288; PIGA; 1.
PE 3: Inferred from homology;
KW Glycosyltransferase; GPI-anchor biosynthesis; Reference proteome;
KW Transferase.
FT CHAIN 1..456
FT /note="Phosphatidylinositol N-acetylglucosaminyltransferase
FT gpi3 subunit"
FT /id="PRO_0000339138"
SQ SEQUENCE 456 AA; 51778 MW; 829C189D186A1919 CRC64;
MVSDFFFPQP GGIESHIFQL SQRLIDLGHK VIVITHAYKD RVGVRYLTNG LTVYYVPLHT
VYRETTFPSF FSFFPIFRNI VIRENIEIVH GHGSLSFLCH DAILHARTMG LKTCFTDHSL
FGFADAGSIV TNKLLKFTMS DVNHVICVSH TCRENTVLRA VLNPKRVSVI PNALVAENFQ
PDPSKASKDF LTIVVISRLY YNKGIDLLIA VIPRICAQHP KVRFVIAGDG PKSIDLEQMR
EKYMLQDRVE MLGSVRHDQV RDVMVRGHIY LHPSLTEAFG TVLVEAASCG LYVISTKVGG
VPEVLPSHMT RFARPEEDDL ADTLSSVITD YLDHKIKTET FHEEVKQMYS WIDVAERTEK
VYDSICSENN LRLIDRLKLY YGCGQWAGKL FCLLIAIDYL VMVLLEWIWP ASDIDPAVDR
VSSTFKISKQ NFDESLVLTD PKKKTKIKTA CLKDAQ
