位置:首页 > 蛋白库 > GPIX_MOUSE
GPIX_MOUSE
ID   GPIX_MOUSE              Reviewed;         177 AA.
AC   O88186;
DT   07-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   03-AUG-2022, entry version 133.
DE   RecName: Full=Platelet glycoprotein IX;
DE            Short=GP-IX;
DE            Short=GPIX;
DE   AltName: Full=Glycoprotein 9;
DE   AltName: CD_antigen=CD42a;
DE   Flags: Precursor;
GN   Name=Gp9;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=9690810; DOI=10.1097/00001721-199806000-00011;
RA   Kitaguchi T., Murata M., Ambo H., Ikeda Y.;
RT   "Characterization of cDNA encoding full-length mouse platelet glycoprotein
RT   IX.";
RL   Blood Coagul. Fibrinolysis 9:381-385(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Spleen;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
CC   -!- FUNCTION: The GPIb-V-IX complex functions as the vWF receptor and
CC       mediates vWF-dependent platelet adhesion to blood vessels. The adhesion
CC       of platelets to injured vascular surfaces in the arterial circulation
CC       is a critical initiating event in hemostasis. GP-IX may provide for
CC       membrane insertion and orientation of GP-Ib (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Two GP-Ib beta are disulfide-linked to one GP-Ib alpha. GP-IX
CC       is complexed with the GP-Ib heterodimer via a non covalent linkage (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Single-pass type I
CC       membrane protein {ECO:0000250}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AB007464; BAA31694.1; -; mRNA.
DR   EMBL; CH466523; EDK99218.1; -; Genomic_DNA.
DR   EMBL; BC111106; AAI11107.1; -; mRNA.
DR   CCDS; CCDS20328.1; -.
DR   RefSeq; NP_061232.1; NM_018762.1.
DR   AlphaFoldDB; O88186; -.
DR   SMR; O88186; -.
DR   ComplexPortal; CPX-115; Glycoprotein Ib-IX-V complex.
DR   ComplexPortal; CPX-118; Glycoprotein Ib-IX-V-Filamin-A complex.
DR   STRING; 10090.ENSMUSP00000032133; -.
DR   GlyGen; O88186; 1 site.
DR   PhosphoSitePlus; O88186; -.
DR   MaxQB; O88186; -.
DR   PaxDb; O88186; -.
DR   PRIDE; O88186; -.
DR   ProteomicsDB; 267761; -.
DR   Antibodypedia; 17356; 517 antibodies from 38 providers.
DR   DNASU; 54368; -.
DR   Ensembl; ENSMUST00000032133; ENSMUSP00000032133; ENSMUSG00000030054.
DR   GeneID; 54368; -.
DR   KEGG; mmu:54368; -.
DR   UCSC; uc009ctv.1; mouse.
DR   CTD; 2815; -.
DR   MGI; MGI:1860137; Gp9.
DR   VEuPathDB; HostDB:ENSMUSG00000030054; -.
DR   eggNOG; KOG0619; Eukaryota.
DR   GeneTree; ENSGT00530000064244; -.
DR   HOGENOM; CLU_094615_1_1_1; -.
DR   InParanoid; O88186; -.
DR   OMA; GYELGSC; -.
DR   OrthoDB; 1229279at2759; -.
DR   PhylomeDB; O88186; -.
DR   Reactome; R-MMU-140837; Intrinsic Pathway of Fibrin Clot Formation.
DR   Reactome; R-MMU-430116; GP1b-IX-V activation signalling.
DR   Reactome; R-MMU-75892; Platelet Adhesion to exposed collagen.
DR   Reactome; R-MMU-76009; Platelet Aggregation (Plug Formation).
DR   BioGRID-ORCS; 54368; 1 hit in 72 CRISPR screens.
DR   PRO; PR:O88186; -.
DR   Proteomes; UP000000589; Chromosome 6.
DR   RNAct; O88186; protein.
DR   Bgee; ENSMUSG00000030054; Expressed in skin of snout and 47 other tissues.
DR   Genevisible; O88186; MM.
DR   GO; GO:1990779; C:glycoprotein Ib-IX-V complex; ISO:MGI.
DR   GO; GO:0007596; P:blood coagulation; IDA:ComplexPortal.
DR   GO; GO:0007597; P:blood coagulation, intrinsic pathway; ISO:MGI.
DR   GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR   GO; GO:0035855; P:megakaryocyte development; IMP:ComplexPortal.
DR   GO; GO:0010572; P:positive regulation of platelet activation; ISO:MGI.
DR   GO; GO:0051209; P:release of sequestered calcium ion into cytosol; ISO:MGI.
DR   Gene3D; 3.80.10.10; -; 1.
DR   InterPro; IPR000483; Cys-rich_flank_reg_C.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR000372; LRRNT.
DR   Pfam; PF13855; LRR_8; 1.
DR   Pfam; PF01462; LRRNT; 1.
DR   SMART; SM00082; LRRCT; 1.
DR   SMART; SM00013; LRRNT; 1.
PE   1: Evidence at protein level;
KW   Blood coagulation; Cell adhesion; Disulfide bond; Glycoprotein; Hemostasis;
KW   Leucine-rich repeat; Membrane; Reference proteome; Signal; Transmembrane;
KW   Transmembrane helix.
FT   SIGNAL          1..16
FT                   /evidence="ECO:0000250"
FT   CHAIN           17..177
FT                   /note="Platelet glycoprotein IX"
FT                   /id="PRO_0000378456"
FT   TOPO_DOM        17..147
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        148..168
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        169..177
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          17..51
FT                   /note="LRRNT"
FT   REPEAT          60..83
FT                   /note="LRR"
FT   DOMAIN          85..137
FT                   /note="LRRCT"
FT   CARBOHYD        60
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   177 AA;  19664 MW;  EB82B952BD3DD7C4 CRC64;
     MTTWGLLFLL WPATTDTQAC PRPCTCQSLE TMGLKVNCEG QGLTALPVIP AHTRQLLLAN
     NSLRSVPPGA FDHLPQLWDL DVTHNPWHCD CSLTYLRLWL EDHMPEALMH VYCASPDLAT
     RRPLGQLTGY ELGSCGWKLP PSWAYPGVWW DVSLVAVAVL GLILLAGLLN TFTESRN
 
 
维奥蛋白资源库 - 中文蛋白资源 CopyRight © 2010-2024