GPI_SINMW
ID GPI_SINMW Reviewed; 214 AA.
AC A6UCB5;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 21-AUG-2007, sequence version 1.
DT 03-AUG-2022, entry version 74.
DE RecName: Full=Glucose-6-phosphate isomerase {ECO:0000255|HAMAP-Rule:MF_01410};
DE Short=GPI {ECO:0000255|HAMAP-Rule:MF_01410};
DE EC=5.3.1.9 {ECO:0000255|HAMAP-Rule:MF_01410};
DE AltName: Full=Phosphoglucose isomerase {ECO:0000255|HAMAP-Rule:MF_01410};
DE Short=PGI {ECO:0000255|HAMAP-Rule:MF_01410};
DE AltName: Full=Phosphohexose isomerase {ECO:0000255|HAMAP-Rule:MF_01410};
DE Short=PHI {ECO:0000255|HAMAP-Rule:MF_01410};
GN Name=pgiA {ECO:0000255|HAMAP-Rule:MF_01410}; OrderedLocusNames=Smed_2463;
OS Sinorhizobium medicae (strain WSM419) (Ensifer medicae).
OC Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC Rhizobiaceae; Sinorhizobium/Ensifer group; Sinorhizobium.
OX NCBI_TaxID=366394;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=WSM419;
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E.,
RA Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J.,
RA Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Reeve W.G.,
RA Richardson P.;
RT "Complete sequence of Sinorhizobium medicae WSM419 chromosome.";
RL Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=alpha-D-glucose 6-phosphate = beta-D-fructose 6-phosphate;
CC Xref=Rhea:RHEA:11816, ChEBI:CHEBI:57634, ChEBI:CHEBI:58225;
CC EC=5.3.1.9; Evidence={ECO:0000255|HAMAP-Rule:MF_01410};
CC -!- PATHWAY: Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-
CC phosphate and glycerone phosphate from D-glucose: step 2/4.
CC {ECO:0000255|HAMAP-Rule:MF_01410}.
CC -!- SUBUNIT: Homodimer. {ECO:0000255|HAMAP-Rule:MF_01410}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01410}.
CC -!- SIMILARITY: Belongs to the archaeal-type GPI family.
CC {ECO:0000255|HAMAP-Rule:MF_01410}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP000738; ABR61295.1; -; Genomic_DNA.
DR RefSeq; WP_012066686.1; NC_009636.1.
DR RefSeq; YP_001328130.1; NC_009636.1.
DR AlphaFoldDB; A6UCB5; -.
DR SMR; A6UCB5; -.
DR STRING; 366394.Smed_2463; -.
DR EnsemblBacteria; ABR61295; ABR61295; Smed_2463.
DR GeneID; 61611297; -.
DR KEGG; smd:Smed_2463; -.
DR PATRIC; fig|366394.8.peg.5649; -.
DR eggNOG; COG2140; Bacteria.
DR HOGENOM; CLU_105797_0_0_5; -.
DR OMA; YPADAGH; -.
DR OrthoDB; 1276228at2; -.
DR UniPathway; UPA00109; UER00181.
DR Proteomes; UP000001108; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0004347; F:glucose-6-phosphate isomerase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR GO; GO:0006094; P:gluconeogenesis; IEA:UniProtKB-UniRule.
DR GO; GO:0006096; P:glycolytic process; IEA:UniProtKB-UniRule.
DR Gene3D; 2.60.120.10; -; 1.
DR HAMAP; MF_01410; G6P_isomerase_arch; 1.
DR InterPro; IPR016758; G6P_isomerase_archaea/bacteria.
DR InterPro; IPR010551; G6P_isomerase_prok.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR InterPro; IPR011051; RmlC_Cupin_sf.
DR Pfam; PF06560; GPI; 1.
DR PIRSF; PIRSF019325; Glucose-6-phosphate_isomerase; 1.
DR SUPFAM; SSF51182; SSF51182; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Gluconeogenesis; Glycolysis; Iron; Isomerase; Metal-binding.
FT CHAIN 1..214
FT /note="Glucose-6-phosphate isomerase"
FT /id="PRO_1000068451"
FT BINDING 92
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01410"
FT BINDING 94
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01410"
FT BINDING 101
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01410"
FT BINDING 140
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01410"
SQ SEQUENCE 214 AA; 23911 MW; 6A2E7CA62D19768B CRC64;
MTKLFEPAAC QVDLRTGAMS AATGAYQKRF RDLAGLYADE AAFSAMRENW NDTVVYEVSE
FRPNERSGDL IFGTTRMLPG KVGDEYFVTR GHIHRQSDRP EIYYGQKGSG LMLLESPEGE
VRIVAIDART VCYVPPYWIH RSVNIGGEEL VMLFCYPADS GQDYDCIAKA GGMRVRIVDD
GEGGWKQVDN SSWRKRDAAT IAALYGLEKK EKSA
