ID   GPKOW_CAEEL             Reviewed;         462 AA.
AC   Q21924;
DT   20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 143.
DE   RecName: Full=G-patch domain and KOW motifs-containing protein homolog 1 {ECO:0000312|WormBase:R11A8.2};
DE   AltName: Full=Protein mos-2 homolog {ECO:0000250|UniProtKB:Q9C801};
GN   Name=gkow-1 {ECO:0000312|WormBase:R11A8.2};
GN   Synonyms=mos-2 {ECO:0000303|PubMed:16271871};
GN   ORFNames=R11A8.2 {ECO:0000312|WormBase:R11A8.2};
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
RN   [2]
RP   IDENTIFICATION.
RX   PubMed=16271871; DOI=10.1016/j.cub.2005.09.038;
RA   Zhang Y., Cheng Y.T., Bi D., Palma K., Li X.;
RT   "MOS2, a protein containing G-patch and KOW motifs, is essential for innate
RT   immunity in Arabidopsis thaliana.";
RL   Curr. Biol. 15:1936-1942(2005).
CC   -!- INTERACTION:
CC       Q21924; Q22387: CELE_T11B7.1; NbExp=3; IntAct=EBI-326087, EBI-320525;
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9C801}.
CC   -!- SIMILARITY: Belongs to the MOS2 family. {ECO:0000305}.
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DR   EMBL; Z70310; CAA94367.1; -; Genomic_DNA.
DR   PIR; T24174; T24174.
DR   RefSeq; NP_501910.1; NM_069509.1.
DR   AlphaFoldDB; Q21924; -.
DR   SMR; Q21924; -.
DR   BioGRID; 43025; 3.
DR   DIP; DIP-25314N; -.
DR   IntAct; Q21924; 2.
DR   STRING; 6239.R11A8.2; -.
DR   EPD; Q21924; -.
DR   PaxDb; Q21924; -.
DR   PeptideAtlas; Q21924; -.
DR   EnsemblMetazoa; R11A8.2.1; R11A8.2.1; WBGene00011237.
DR   GeneID; 177923; -.
DR   KEGG; cel:CELE_R11A8.2; -.
DR   UCSC; R11A8.2; c. elegans.
DR   CTD; 177923; -.
DR   WormBase; R11A8.2; CE06300; WBGene00011237; gkow-1.
DR   eggNOG; KOG4315; Eukaryota.
DR   GeneTree; ENSGT00390000015154; -.
DR   HOGENOM; CLU_496301_0_0_1; -.
DR   InParanoid; Q21924; -.
DR   OMA; VEGNRVM; -.
DR   OrthoDB; 996115at2759; -.
DR   PhylomeDB; Q21924; -.
DR   Reactome; R-CEL-72163; mRNA Splicing - Major Pathway.
DR   PRO; PR:Q21924; -.
DR   Proteomes; UP000001940; Chromosome IV.
DR   Bgee; WBGene00011237; Expressed in germ line (C elegans) and 4 other tissues.
DR   GO; GO:0005681; C:spliceosomal complex; IBA:GO_Central.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0000398; P:mRNA splicing, via spliceosome; IBA:GO_Central.
DR   CDD; cd13153; KOW_GPKOW_B; 1.
DR   InterPro; IPR000467; G_patch_dom.
DR   InterPro; IPR041994; GPKOW_KOW2.
DR   InterPro; IPR005824; KOW.
DR   InterPro; IPR045166; Spp2-like.
DR   InterPro; IPR026822; Spp2/MOS2_G-patch.
DR   PANTHER; PTHR15818; PTHR15818; 1.
DR   Pfam; PF12656; G-patch_2; 1.
DR   SMART; SM00443; G_patch; 1.
DR   SMART; SM00739; KOW; 2.
DR   PROSITE; PS50174; G_PATCH; 1.
PE   1: Evidence at protein level;
KW   Nucleus; Reference proteome; Repeat.
FT   CHAIN           1..462
FT                   /note="G-patch domain and KOW motifs-containing protein
FT                   homolog 1"
FT                   /id="PRO_0000280566"
FT   DOMAIN          154..202
FT                   /note="G-patch"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00092"
FT   DOMAIN          221..248
FT                   /note="KOW 1"
FT   DOMAIN          401..428
FT                   /note="KOW 2"
FT   REGION          1..26
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          182..218
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          289..337
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        289..305
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        306..321
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        322..337
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   462 AA;  51712 MW;  13181C5570C111A8 CRC64;
     MVEQTTSEPA AGSMPKISFG VKKREENKVQ APAKAVVIEV DLDSDEEREK NEMERAAKRR
     KVMHFEDGTV QGDIDKPKEA AVIPMVVEHD WRTQKLIEKE KAGTLTEEER AKLALVLPNG
     IDGENEEESG KGEKIVVEDG RGDTEDADYS AIPIESFGLA ILRGCNWKDG DGIGKNPQKV
     ALKLPNRRPP GLGLGATPKN PVGKNKNTGE SSKAEEEKLE EIKVGSFIKV VDGRNKGVYG
     KVEGRDDDSN SLFIRTAIGG KTMKVSQIVA VAVSAKEYER DSKCLNKSEY DKEKDRLETE
     RKKLESQPPS TSTSQSSKDY KSKSSSSKHD KNSSEYERND KMWARTDLLV RFIDEDFKRG
     SLYEQKVRIV DVAGDNDVTI EDDRGNTHYN IRQSWLETVI PREIGEKLMI VAGKRSGQLA
     VMLDKDKRKE KVTARLVATN DVVTAYFEDV CSVKIRHEED YE