GPKOW_DANRE
ID GPKOW_DANRE Reviewed; 506 AA.
AC Q90X38; Q0IIR0; Q1JQ02; Q3B7E2;
DT 20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 2.
DT 03-AUG-2022, entry version 108.
DE RecName: Full=G-patch domain and KOW motifs-containing protein;
DE AltName: Full=Protein T54-like;
GN Name=gpkow; Synonyms=t54l; ORFNames=si:dz150f13.5, zgc:152714;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen;
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-361.
RC TISSUE=Eye, Larva, and Olfactory epithelium;
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: RNA-binding protein involved in pre-mRNA splicing.
CC {ECO:0000250|UniProtKB:Q92917}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q92917}.
CC -!- SIMILARITY: Belongs to the MOS2 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAI21739.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AL591213; CAD10081.2; -; Genomic_DNA.
DR EMBL; BC107644; AAI07645.1; ALT_TERM; mRNA.
DR EMBL; BC116535; AAI16536.1; ALT_TERM; mRNA.
DR EMBL; BC121738; AAI21739.1; ALT_FRAME; mRNA.
DR RefSeq; NP_001007208.1; NM_001007207.1.
DR AlphaFoldDB; Q90X38; -.
DR SMR; Q90X38; -.
DR STRING; 7955.ENSDARP00000047911; -.
DR PaxDb; Q90X38; -.
DR PRIDE; Q90X38; -.
DR GeneID; 368735; -.
DR KEGG; dre:368735; -.
DR CTD; 27238; -.
DR ZFIN; ZDB-GENE-030616-159; gpkow.
DR eggNOG; KOG4315; Eukaryota.
DR InParanoid; Q90X38; -.
DR OrthoDB; 1427830at2759; -.
DR PhylomeDB; Q90X38; -.
DR Reactome; R-DRE-72163; mRNA Splicing - Major Pathway.
DR PRO; PR:Q90X38; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Unplaced.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0005681; C:spliceosomal complex; ISS:UniProtKB.
DR GO; GO:0003723; F:RNA binding; ISS:UniProtKB.
DR GO; GO:0000398; P:mRNA splicing, via spliceosome; ISS:UniProtKB.
DR CDD; cd13152; KOW_GPKOW_A; 1.
DR CDD; cd13153; KOW_GPKOW_B; 1.
DR Gene3D; 2.30.30.30; -; 1.
DR InterPro; IPR000467; G_patch_dom.
DR InterPro; IPR041993; GPKOW_KOW1.
DR InterPro; IPR041994; GPKOW_KOW2.
DR InterPro; IPR005824; KOW.
DR InterPro; IPR014722; Rib_L2_dom2.
DR InterPro; IPR045166; Spp2-like.
DR InterPro; IPR026822; Spp2/MOS2_G-patch.
DR InterPro; IPR008991; Translation_prot_SH3-like_sf.
DR PANTHER; PTHR15818; PTHR15818; 1.
DR Pfam; PF12656; G-patch_2; 1.
DR Pfam; PF00467; KOW; 1.
DR SMART; SM00443; G_patch; 1.
DR SMART; SM00739; KOW; 2.
DR SUPFAM; SSF50104; SSF50104; 1.
DR PROSITE; PS50174; G_PATCH; 1.
PE 2: Evidence at transcript level;
KW Coiled coil; mRNA processing; mRNA splicing; Nucleus; Reference proteome;
KW Repeat; RNA-binding.
FT CHAIN 1..506
FT /note="G-patch domain and KOW motifs-containing protein"
FT /id="PRO_0000280564"
FT DOMAIN 176..222
FT /note="G-patch"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00092"
FT DOMAIN 250..277
FT /note="KOW 1"
FT DOMAIN 447..474
FT /note="KOW 2"
FT REGION 1..28
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 83..110
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 211..247
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 310..389
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 303..346
FT /evidence="ECO:0000255"
FT COMPBIAS 1..22
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 83..103
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 226..247
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 310..378
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 23
FT /note="G -> A (in Ref. 2; AAI21739)"
FT /evidence="ECO:0000305"
FT CONFLICT 47
FT /note="E -> V (in Ref. 2; AAI07645)"
FT /evidence="ECO:0000305"
FT CONFLICT 185
FT /note="K -> R (in Ref. 2; AAI16536)"
FT /evidence="ECO:0000305"
FT CONFLICT 231
FT /note="V -> I (in Ref. 2; AAI21739)"
FT /evidence="ECO:0000305"
FT CONFLICT 246
FT /note="E -> D (in Ref. 2; AAI21739)"
FT /evidence="ECO:0000305"
FT CONFLICT 292
FT /note="V -> A (in Ref. 2; AAI21739)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 506 AA; 57955 MW; 358033FD732F6F25 CRC64;
MASPERYQER ESLKKDISQD DGGKKAAPIS FGFSKTLIKV KSGKAEERDY LVEVEGKELK
GTKPVEKPKE LIIPLIHKNR WYRQDAERAD KTSEEKTEEP SQVKQDTVES QAVKELIEES
QKYQDRWKNG PQSDPNFAIP LLMQNQVPDG FEDGDKVNVD LRPESSTEAD YERVPVEAYG
LAMLKGMGWK QEEGIGRTFK QDVKPIEHQL RPKGLGLGAD RSAIKDLEPG VPKRPPKPGD
EKGKEEEALV LGPGGCVQVL AGAHKDLYGK IEGVDPDNGR VVVKLAIGGK TVTIIQHSIK
LVTRKEYDKY SKDLSRLSKA HKDKEREKER EQKREQEQRL NGKDERGKTD RSREKDRDQK
KRKHRESSTD REKPPPAKES RSSPPAPSWL QRDLRVRFID KAFKGGKYYN SKMRVEDVLT
PHTCVCRTEE GRMLDDIRQK MLETIVPKND SDYIMVVLGE HRGQVGRILK RDREKCRAMV
QLDRYEERVF TLDYDTICHY VGGTDH
