ID   GPKOW_XENLA             Reviewed;         487 AA.
AC   Q6NU07;
DT   20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 73.
DE   RecName: Full=G-patch domain and KOW motifs-containing protein;
GN   Name=gpkow;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: RNA-binding protein involved in pre-mRNA splicing.
CC       {ECO:0000250|UniProtKB:Q92917}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q92917}.
CC   -!- SIMILARITY: Belongs to the MOS2 family. {ECO:0000305}.
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DR   EMBL; BC068795; AAH68795.1; -; mRNA.
DR   RefSeq; NP_001084514.1; NM_001091045.1.
DR   AlphaFoldDB; Q6NU07; -.
DR   SMR; Q6NU07; -.
DR   IntAct; Q6NU07; 1.
DR   DNASU; 414461; -.
DR   GeneID; 414461; -.
DR   KEGG; xla:414461; -.
DR   CTD; 414461; -.
DR   Xenbase; XB-GENE-943880; gpkow.S.
DR   OMA; VEGNRVM; -.
DR   OrthoDB; 1427830at2759; -.
DR   Proteomes; UP000186698; Chromosome 8S.
DR   Bgee; 414461; Expressed in egg cell and 19 other tissues.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0005681; C:spliceosomal complex; ISS:UniProtKB.
DR   GO; GO:0003723; F:RNA binding; ISS:UniProtKB.
DR   GO; GO:0000398; P:mRNA splicing, via spliceosome; ISS:UniProtKB.
DR   CDD; cd13152; KOW_GPKOW_A; 1.
DR   CDD; cd13153; KOW_GPKOW_B; 1.
DR   Gene3D; 2.30.30.30; -; 2.
DR   InterPro; IPR000467; G_patch_dom.
DR   InterPro; IPR041993; GPKOW_KOW1.
DR   InterPro; IPR041994; GPKOW_KOW2.
DR   InterPro; IPR005824; KOW.
DR   InterPro; IPR014722; Rib_L2_dom2.
DR   InterPro; IPR045166; Spp2-like.
DR   InterPro; IPR026822; Spp2/MOS2_G-patch.
DR   InterPro; IPR008991; Translation_prot_SH3-like_sf.
DR   PANTHER; PTHR15818; PTHR15818; 1.
DR   Pfam; PF12656; G-patch_2; 1.
DR   Pfam; PF00467; KOW; 1.
DR   SMART; SM00443; G_patch; 1.
DR   SMART; SM00739; KOW; 2.
DR   SUPFAM; SSF50104; SSF50104; 1.
DR   PROSITE; PS50174; G_PATCH; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; mRNA processing; mRNA splicing; Nucleus; Reference proteome;
KW   Repeat; RNA-binding.
FT   CHAIN           1..487
FT                   /note="G-patch domain and KOW motifs-containing protein"
FT                   /id="PRO_0000280565"
FT   DOMAIN          154..200
FT                   /note="G-patch"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00092"
FT   DOMAIN          226..253
FT                   /note="KOW 1"
FT   DOMAIN          428..455
FT                   /note="KOW 2"
FT   REGION          65..121
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          181..232
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          295..367
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          88..116
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        68..83
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        92..107
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        202..225
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        295..329
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        341..367
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   487 AA;  54696 MW;  8703DD3E7F3032F5 CRC64;
     MAAAGSSQAP ISFGFNRSSK KKLLVSDGEK EEEHEKEYLV GAEGKELLSA NPAPESKPLV
     IPLIHKNRWA KPNKDKEEDA APQTEDEAVL SQAVKELIEE SRRAQEDNSE TNQTLSIPLL
     MQNRMPDGYE DREKVDVSLR PDSAEAADYD VVPVQQYGMA MLRGMGWKEG EGIGRTFKQD
     VKPLEQKLRP KGLGLGADRS ALKHLEPQKP RKPLKPGEEP EEESKGLGTG SAVQIQSGAY
     KDMYGKVEGI DPDNSRAMIT LAIGGKVVTV SLFSLRLVNS AEYTKYAKDL SRLSKVHQES
     KVEPHRDRTP EKEQGRKGGE KRSESSRNAD VKLSKSSGNG DSNNREKRHR QRSPEQEKEK
     KKIRPEPHGW LRRDIRVRFI DKNYKGGKYY NSKMLVEDVL SPTRCVCRTE NGCILEDIRQ
     DMLETIIPKE EGEHVMVVLG KYRGMVGKIL HRDKQKSRAL VQLQGEHDSA ETLSYDAICH
     YTGAQDD