GPLPB_ARATH
ID GPLPB_ARATH Reviewed; 326 AA.
AC Q9C4Z6; Q42130; Q8LAF2;
DT 11-JAN-2011, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 25-MAY-2022, entry version 128.
DE RecName: Full=Receptor for activated C kinase 1B {ECO:0000303|PubMed:16829549};
DE AltName: Full=Guanine nucleotide-binding protein subunit beta-like protein B;
GN Name=RACK1B {ECO:0000303|PubMed:16829549};
GN OrderedLocusNames=At1g48630 {ECO:0000312|Araport:AT1G48630};
GN ORFNames=F11I4.18 {ECO:0000312|EMBL:AAG60127.1},
GN F9P7.2 {ECO:0000312|EMBL:AAG50846.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA Feldmann K.A.;
RT "Full-length cDNA from Arabidopsis thaliana.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 263-326.
RC STRAIN=cv. Columbia;
RX PubMed=8281187; DOI=10.1046/j.1365-313x.1993.04061051.x;
RA Hoefte H., Desprez T., Amselem J., Chiapello H., Rouze P., Caboche M.,
RA Moisan A., Jourjon M.-F., Charpenteau J.-L., Berthomieu P., Guerrier D.,
RA Giraudat J., Quigley F., Thomas F., Yu D.-Y., Mache R., Raynal M.,
RA Cooke R., Grellet F., Delseny M., Parmentier Y., de Marcillac G., Gigot C.,
RA Fleck J., Philipps G., Axelos M., Bardet C., Tremousaygue D., Lescure B.;
RT "An inventory of 1152 expressed sequence tags obtained by partial
RT sequencing of cDNAs from Arabidopsis thaliana.";
RL Plant J. 4:1051-1061(1993).
RN [6]
RP TISSUE SPECIFICITY.
RX PubMed=16829549; DOI=10.1093/jxb/erl035;
RA Chen J.G., Ullah H., Temple B., Liang J., Guo J., Alonso J.M., Ecker J.R.,
RA Jones A.M.;
RT "RACK1 mediates multiple hormone responsiveness and developmental processes
RT in Arabidopsis.";
RL J. Exp. Bot. 57:2697-2708(2006).
RN [7]
RP FUNCTION, TISSUE SPECIFICITY, AND DISRUPTION PHENOTYPE.
RX PubMed=18947417; DOI=10.1186/1471-2229-8-108;
RA Guo J., Chen J.G.;
RT "RACK1 genes regulate plant development with unequal genetic redundancy in
RT Arabidopsis.";
RL BMC Plant Biol. 8:108-108(2008).
RN [8]
RP FUNCTION, AND INTERACTION WITH GB1; MEKK1; MKK4; MKK5; MPK3 AND MPK6.
RX PubMed=25731164; DOI=10.1038/nature14243;
RA Cheng Z., Li J.F., Niu Y., Zhang X.C., Woody O.Z., Xiong Y., Djonovic S.,
RA Millet Y., Bush J., McConkey B.J., Sheen J., Ausubel F.M.;
RT "Pathogen-secreted proteases activate a novel plant immune pathway.";
RL Nature 521:213-216(2015).
CC -!- FUNCTION: Minor component of the RACK1 regulatory proteins that play a
CC role in multiple signal transduction pathways. Involved in multiple
CC hormone responses and developmental processes (PubMed:18947417). MAPK
CC cascade scaffolding protein involved in the protease IV and ArgC
CC signaling pathway but not the flg22 pathway (PubMed:25731164).
CC {ECO:0000269|PubMed:18947417, ECO:0000269|PubMed:25731164}.
CC -!- SUBUNIT: Homodimer and heterodimer with RACK1A or RACK1B (Probable).
CC Interacts with GB1, MEKK1, MKK4, MKK5, MPK3 and MPK6, but not with GPA1
CC or MPK4 (PubMed:25731164). {ECO:0000269|PubMed:25731164, ECO:0000305}.
CC -!- INTERACTION:
CC Q9C4Z6; Q700C7: SPCH; NbExp=3; IntAct=EBI-4457470, EBI-15976443;
CC -!- TISSUE SPECIFICITY: Widely expressed. {ECO:0000269|PubMed:16829549,
CC ECO:0000269|PubMed:18947417}.
CC -!- DISRUPTION PHENOTYPE: No visible phenotype under normal growth
CC condition. {ECO:0000269|PubMed:18947417}.
CC -!- SIMILARITY: Belongs to the WD repeat G protein beta family. Ribosomal
CC protein RACK1 subfamily. {ECO:0000305}.
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DR EMBL; AC073555; AAG60127.1; -; Genomic_DNA.
DR EMBL; AC074308; AAG50846.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE32329.1; -; Genomic_DNA.
DR EMBL; AY059723; AAL24080.1; -; mRNA.
DR EMBL; AY091352; AAM14291.1; -; mRNA.
DR EMBL; AY087855; AAM65407.1; -; mRNA.
DR EMBL; Z26552; CAA81323.1; -; mRNA.
DR RefSeq; NP_175296.1; NM_103759.5.
DR AlphaFoldDB; Q9C4Z6; -.
DR SMR; Q9C4Z6; -.
DR BioGRID; 26509; 14.
DR IntAct; Q9C4Z6; 4.
DR STRING; 3702.AT1G48630.1; -.
DR PaxDb; Q9C4Z6; -.
DR PRIDE; Q9C4Z6; -.
DR ProteomicsDB; 248513; -.
DR EnsemblPlants; AT1G48630.1; AT1G48630.1; AT1G48630.
DR GeneID; 841284; -.
DR Gramene; AT1G48630.1; AT1G48630.1; AT1G48630.
DR KEGG; ath:AT1G48630; -.
DR Araport; AT1G48630; -.
DR TAIR; locus:2008159; AT1G48630.
DR eggNOG; KOG0279; Eukaryota.
DR HOGENOM; CLU_000288_57_7_1; -.
DR InParanoid; Q9C4Z6; -.
DR OMA; TIKICNT; -.
DR OrthoDB; 805365at2759; -.
DR PhylomeDB; Q9C4Z6; -.
DR PRO; PR:Q9C4Z6; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q9C4Z6; baseline and differential.
DR Genevisible; Q9C4Z6; AT.
DR GO; GO:0005829; C:cytosol; IDA:TAIR.
DR GO; GO:0022626; C:cytosolic ribosome; HDA:TAIR.
DR GO; GO:0005634; C:nucleus; IDA:TAIR.
DR GO; GO:0042788; C:polysomal ribosome; IDA:CAFA.
DR GO; GO:0015935; C:small ribosomal subunit; IEA:InterPro.
DR GO; GO:0005078; F:MAP-kinase scaffold activity; IMP:UniProtKB.
DR GO; GO:0005080; F:protein kinase C binding; IBA:GO_Central.
DR GO; GO:0043022; F:ribosome binding; IBA:GO_Central.
DR GO; GO:0003735; F:structural constituent of ribosome; IDA:CAFA.
DR GO; GO:0071215; P:cellular response to abscisic acid stimulus; IEP:TAIR.
DR GO; GO:0001934; P:positive regulation of protein phosphorylation; IBA:GO_Central.
DR GO; GO:0009967; P:positive regulation of signal transduction; IMP:UniProtKB.
DR GO; GO:0006417; P:regulation of translation; IGI:TAIR.
DR GO; GO:0072344; P:rescue of stalled ribosome; IBA:GO_Central.
DR GO; GO:0042254; P:ribosome biogenesis; IGI:TAIR.
DR GO; GO:0048364; P:root development; IGI:TAIR.
DR GO; GO:0009845; P:seed germination; IGI:TAIR.
DR GO; GO:0048367; P:shoot system development; IGI:TAIR.
DR GO; GO:0007165; P:signal transduction; IEA:UniProtKB-KW.
DR Gene3D; 2.130.10.10; -; 1.
DR InterPro; IPR045223; Asc1/RACK1.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR19868; PTHR19868; 1.
DR Pfam; PF00400; WD40; 7.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 4.
DR PROSITE; PS50082; WD_REPEATS_2; 7.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 1: Evidence at protein level;
KW Reference proteome; Repeat; Ribonucleoprotein; Ribosomal protein;
KW Transducer; WD repeat.
FT CHAIN 1..326
FT /note="Receptor for activated C kinase 1B"
FT /id="PRO_0000403654"
FT REPEAT 13..53
FT /note="WD 1"
FT REPEAT 61..100
FT /note="WD 2"
FT REPEAT 103..142
FT /note="WD 3"
FT REPEAT 147..188
FT /note="WD 4"
FT REPEAT 191..230
FT /note="WD 5"
FT REPEAT 232..270
FT /note="WD 6"
FT REPEAT 290..326
FT /note="WD 7"
FT CONFLICT 315
FT /note="D -> H (in Ref. 4; AAM65407)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 326 AA; 35801 MW; FF2436CDA85F8DA7 CRC64;
MAEGLVLKGT MCAHTDMVTA IATPVDNSDV IVTSSRDKSI ILWKLTKEDK SYGVAQRRMT
GHSHFVQDVV LSSDGQFALS GSWDGELRLW DLATGESTRR FVGHTKDVLS VAFSTDNRQI
VSASRDRTIK LWNTLGECKY TISEADGHKE WVSCVRFSPN TLVPTIVSAS WDKTVKVWNL
QNCKLRNTLA GHSGYLNTVA VSPDGSLCAS GGKDGVILLW DLAEGKKLYS LEAGSIIHSL
CFSPNRYWLC AATENSIRIW DLESKSVVED LKVDLKAEAE KTDGSTGIGN KTKVIYCTSL
NWSADGNTLF SGYTDGVIRV WGIGRY
