ID   GPM6B_PONAB             Reviewed;         265 AA.
AC   Q5R603;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   25-MAY-2022, entry version 53.
DE   RecName: Full=Neuronal membrane glycoprotein M6-b;
DE            Short=M6b;
GN   Name=GPM6B; Synonyms=M6B;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain cortex;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May be involved in neural development. Involved in regulation
CC       of osteoblast function and bone formation. Involved in matrix vesicle
CC       release by osteoblasts; this function seems to involve maintenance of
CC       the actin cytoskeleton. May be involved in cellular trafficking of SERT
CC       and thereby in regulation of serotonin uptake (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with SERT. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}. Cell membrane {ECO:0000250}. Note=Colocalizes
CC       with SERT at the plasma membrane. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the myelin proteolipid protein family.
CC       {ECO:0000305}.
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DR   EMBL; CR860697; CAH92813.1; -; mRNA.
DR   RefSeq; NP_001126642.1; NM_001133170.1.
DR   AlphaFoldDB; Q5R603; -.
DR   GeneID; 100173640; -.
DR   KEGG; pon:100173640; -.
DR   CTD; 2824; -.
DR   InParanoid; Q5R603; -.
DR   OrthoDB; 914457at2759; -.
DR   Proteomes; UP000001595; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0045121; C:membrane raft; ISS:UniProtKB.
DR   GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0085029; P:extracellular matrix assembly; ISS:UniProtKB.
DR   GO; GO:2000009; P:negative regulation of protein localization to cell surface; ISS:UniProtKB.
DR   GO; GO:0051612; P:negative regulation of serotonin uptake; ISS:UniProtKB.
DR   GO; GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
DR   GO; GO:0001503; P:ossification; IEA:UniProtKB-KW.
DR   GO; GO:0030501; P:positive regulation of bone mineralization; ISS:UniProtKB.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   GO; GO:0032956; P:regulation of actin cytoskeleton organization; ISS:UniProtKB.
DR   GO; GO:0051893; P:regulation of focal adhesion assembly; ISS:UniProtKB.
DR   InterPro; IPR001614; Myelin_PLP.
DR   InterPro; IPR018237; Myelin_PLP_CS.
DR   PANTHER; PTHR11683; PTHR11683; 1.
DR   Pfam; PF01275; Myelin_PLP; 1.
DR   PRINTS; PR00214; MYELINPLP.
DR   SMART; SM00002; PLP; 1.
DR   PROSITE; PS00575; MYELIN_PLP_1; 1.
DR   PROSITE; PS01004; MYELIN_PLP_2; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Developmental protein; Differentiation; Glycoprotein;
KW   Membrane; Neurogenesis; Osteogenesis; Phosphoprotein; Protein transport;
KW   Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..265
FT                   /note="Neuronal membrane glycoprotein M6-b"
FT                   /id="PRO_0000159023"
FT   TRANSMEM        31..51
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        90..110
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        136..156
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        224..244
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   MOD_RES         257
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P35803"
FT   CARBOHYD        73
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        177
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   265 AA;  29030 MW;  751EF430E80B41C6 CRC64;
     MKPAMETAAE ENTEQSQKRK GCFECCIKCL GGVPYASLVA TILCFSGVAL FCGCGHVALA
     GTVAILEQHF STNASDHALL SEVIQLMQYV IYGIASFFFL YVIILLAEGF YTTSAVKELH
     GEFKTTACGR CISGMFVFLT YVLGVAWLGV FGFSAVPVFM FYNIWSTCEV IKSPQTNGTT
     GVEQICVDIR QYGIIPWNAF PGKICGSALE NICNTNEFYM SYHLFIVACA GAGATVIALL
     IYMMATTYNY AVLKFKSRED CCTKF