ID   3S1E3_MICPY             Reviewed;          27 AA.
AC   P0CAR5;
DT   16-JUN-2009, integrated into UniProtKB/Swiss-Prot.
DT   16-JUN-2009, sequence version 1.
DT   25-MAY-2022, entry version 24.
DE   RecName: Full=Weak neurotoxin E3;
DE   Flags: Fragment;
OS   Micrurus pyrrhocryptus (Coral snake).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC   Serpentes; Colubroidea; Elapidae; Elapinae; Micrurus.
OX   NCBI_TaxID=129468;
RN   [1]
RP   PROTEIN SEQUENCE, MASS SPECTROMETRY, AND SUBCELLULAR LOCATION.
RC   TISSUE=Venom;
RX   PubMed=19135468; DOI=10.1016/j.toxicon.2008.12.015;
RA   Dokmetjian J.C., Del Canto S., Vinzon S., de Jimenez Bonino M.B.;
RT   "Biochemical characterization of the Micrurus pyrrhocryptus venom.";
RL   Toxicon 53:375-382(2009).
CC   -!- FUNCTION: Binds to muscle nicotinic acetylcholine receptor (nAChR) and
CC       inhibit acetylcholine from binding to the receptor, thereby impairing
CC       neuromuscular transmission. {ECO:0000250|UniProtKB:P60775}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:19135468}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305}.
CC   -!- MASS SPECTROMETRY: Mass=7109; Method=Electrospray;
CC       Evidence={ECO:0000269|PubMed:19135468};
CC   -!- SIMILARITY: Belongs to the snake three-finger toxin family. Short-chain
CC       subfamily. Type I alpha-neurotoxin sub-subfamily. {ECO:0000305}.
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DR   AlphaFoldDB; P0CAR5; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0030550; F:acetylcholine receptor inhibitor activity; IEA:UniProtKB-KW.
DR   GO; GO:0099106; F:ion channel regulator activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Acetylcholine receptor inhibiting toxin; Direct protein sequencing;
KW   Ion channel impairing toxin; Neurotoxin; Postsynaptic neurotoxin; Secreted;
KW   Toxin.
FT   CHAIN           1..>27
FT                   /note="Weak neurotoxin E3"
FT                   /evidence="ECO:0000269|PubMed:19135468"
FT                   /id="PRO_0000377751"
FT   NON_TER         27
SQ   SEQUENCE   27 AA;  3068 MW;  231AD14591187175 CRC64;
     LICFNDFSPT ARTLEYCQIG ITTYNPS