ID   GPN2_BOVIN              Reviewed;         310 AA.
AC   A6H7F2;
DT   15-JUN-2010, integrated into UniProtKB/Swiss-Prot.
DT   24-JUL-2007, sequence version 1.
DT   03-AUG-2022, entry version 83.
DE   RecName: Full=GPN-loop GTPase 2;
DE   AltName: Full=ATP-binding domain 1 family member B;
GN   Name=GPN2; Synonyms=ATPBD1B;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Small GTPase required for proper localization of RNA
CC       polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly
CC       step prior to nuclear import. {ECO:0000250|UniProtKB:Q08726}.
CC   -!- SUBUNIT: Heterodimers with GPN1 or GPN3. Binds to RNA polymerase II
CC       (RNAPII). {ECO:0000250|UniProtKB:Q08726}.
CC   -!- SIMILARITY: Belongs to the GPN-loop GTPase family. {ECO:0000305}.
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DR   EMBL; BC146222; AAI46223.1; -; mRNA.
DR   RefSeq; NP_001092443.1; NM_001098973.1.
DR   AlphaFoldDB; A6H7F2; -.
DR   SMR; A6H7F2; -.
DR   STRING; 9913.ENSBTAP00000019774; -.
DR   PaxDb; A6H7F2; -.
DR   PRIDE; A6H7F2; -.
DR   Ensembl; ENSBTAT00000019774; ENSBTAP00000019774; ENSBTAG00000014850.
DR   GeneID; 514772; -.
DR   KEGG; bta:514772; -.
DR   CTD; 54707; -.
DR   VEuPathDB; HostDB:ENSBTAG00000014850; -.
DR   VGNC; VGNC:29539; GPN2.
DR   eggNOG; KOG1533; Eukaryota.
DR   GeneTree; ENSGT00950000183172; -.
DR   HOGENOM; CLU_037460_0_2_1; -.
DR   InParanoid; A6H7F2; -.
DR   OMA; YAPLPFN; -.
DR   OrthoDB; 964931at2759; -.
DR   TreeFam; TF300828; -.
DR   Proteomes; UP000009136; Chromosome 2.
DR   Bgee; ENSBTAG00000014850; Expressed in oocyte and 104 other tissues.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003924; F:GTPase activity; IBA:GO_Central.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR004130; Gpn.
DR   InterPro; IPR030231; Gpn2.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR21231; PTHR21231; 1.
DR   PANTHER; PTHR21231:SF3; PTHR21231:SF3; 1.
DR   Pfam; PF03029; ATP_bind_1; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; GTP-binding; Hydrolase; Nucleotide-binding;
KW   Reference proteome.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250|UniProtKB:Q9H9Y4"
FT   CHAIN           2..310
FT                   /note="GPN-loop GTPase 2"
FT                   /id="PRO_0000394803"
FT   MOTIF           76..78
FT                   /note="Gly-Pro-Asn (GPN)-loop; involved in dimer interface"
FT                   /evidence="ECO:0000250|UniProtKB:Q9UYR9"
FT   BINDING         19..24
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250|UniProtKB:Q9UYR9"
FT   BINDING         178..181
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250|UniProtKB:Q9UYR9"
FT   SITE            78
FT                   /note="Stabilizes the phosphate intermediate; shared with
FT                   dimeric partner"
FT                   /evidence="ECO:0000250|UniProtKB:Q9UYR9"
FT   MOD_RES         2
FT                   /note="N-acetylalanine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9H9Y4"
SQ   SEQUENCE   310 AA;  34464 MW;  511367A95AFF7894 CRC64;
     MAGAAPTTAF GQAVIGPPGS GKTTYCLGMS EFLRALGRRV AVVNLDPANE GLPYECAVDV
     GELVGLGDVM DALQLGPNGG LLYCMEYLEA NLDWLRAKLD PLRGHYFLFD CPGQVELCTH
     HGALRSIFSQ MTQWDLRLTA VHLVDSHYCT DPAKFISVLC TSLATMLHVE LPHVNLLSKM
     DLIEHYGKLA FNLDYYTEVL DLSYLLDHLA SDPFFRHYRQ LNEKLVQLIE DYSLVSFIPL
     NIQDKESIQQ VLQAVDKANG YCFGVQEQRS LEAMMSAAMG ADFHFSSTLG LQEKYLAPSE
     QSVEQEAMQL