ID   GPN2_DANRE              Reviewed;         311 AA.
AC   Q6PUR6; Q5XIY1;
DT   25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 94.
DE   RecName: Full=GPN-loop GTPase 2 {ECO:0000250|UniProtKB:Q9H9Y4};
DE   AltName: Full=ATP-binding domain 1 family member B {ECO:0000250|UniProtKB:Q9H9Y4};
GN   Name=gpn2 {ECO:0000250|UniProtKB:Q9H9Y4};
GN   Synonyms=atpbd1b {ECO:0000250|UniProtKB:Q9H9Y4}; ORFNames=zgc:92877;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney marrow;
RX   PubMed=15520368; DOI=10.1073/pnas.0407241101;
RA   Song H.-D., Sun X.-J., Deng M., Zhang G.-W., Zhou Y., Wu X.-Y., Sheng Y.,
RA   Chen Y., Ruan Z., Jiang C.-L., Fan H.-Y., Zon L.I., Kanki J.P., Liu T.X.,
RA   Look A.T., Chen Z.;
RT   "Hematopoietic gene expression profile in zebrafish kidney marrow.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:16240-16245(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Small GTPase required for proper localization of RNA
CC       polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly
CC       step prior to nuclear import. {ECO:0000250|UniProtKB:Q08726}.
CC   -!- SUBUNIT: Heterodimers with gpn1 or gpn3. Binds to RNA polymerase II
CC       (RNAPII). {ECO:0000250|UniProtKB:Q08726, ECO:0000250|UniProtKB:Q9H9Y4}.
CC   -!- SIMILARITY: Belongs to the GPN-loop GTPase family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH83538.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC       Sequence=AAS92637.1; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; AY576999; AAS92637.1; ALT_FRAME; mRNA.
DR   EMBL; BC083538; AAH83538.1; ALT_INIT; mRNA.
DR   RefSeq; NP_999966.2; NM_214801.2.
DR   AlphaFoldDB; Q6PUR6; -.
DR   SMR; Q6PUR6; -.
DR   STRING; 7955.ENSDARP00000092687; -.
DR   PaxDb; Q6PUR6; -.
DR   GeneID; 407722; -.
DR   KEGG; dre:407722; -.
DR   CTD; 54707; -.
DR   ZFIN; ZDB-GENE-041010-86; gpn2.
DR   eggNOG; KOG1533; Eukaryota.
DR   InParanoid; Q6PUR6; -.
DR   PhylomeDB; Q6PUR6; -.
DR   PRO; PR:Q6PUR6; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003924; F:GTPase activity; IBA:GO_Central.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR004130; Gpn.
DR   InterPro; IPR030231; Gpn2.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR21231; PTHR21231; 1.
DR   PANTHER; PTHR21231:SF3; PTHR21231:SF3; 1.
DR   Pfam; PF03029; ATP_bind_1; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
PE   2: Evidence at transcript level;
KW   GTP-binding; Hydrolase; Nucleotide-binding; Reference proteome.
FT   CHAIN           1..311
FT                   /note="GPN-loop GTPase 2"
FT                   /id="PRO_0000247832"
FT   MOTIF           77..79
FT                   /note="Gly-Pro-Asn (GPN)-loop; involved in dimer interface"
FT                   /evidence="ECO:0000250|UniProtKB:Q9UYR9"
FT   BINDING         20..25
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250|UniProtKB:Q9UYR9"
FT   BINDING         179..182
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250|UniProtKB:Q9UYR9"
FT   SITE            79
FT                   /note="Stabilizes the phosphate intermediate; shared with
FT                   dimeric partner"
FT                   /evidence="ECO:0000250|UniProtKB:Q9UYR9"
SQ   SEQUENCE   311 AA;  35092 MW;  F73DC11041D7E2DC CRC64;
     MMSSDPPSLR FGQVVIGPPG SGKTTYCRGM QEFLSRLGRK VVIVNLDPAN EGLPYPCAVD
     IAELVTLDDV MDGLKLGPNG GLIYSMEYLE ANLDWLENKL KLHHDCYFLF DCPGQVELYT
     HHNSVKNIFA QLSKWNFRLT AVHLVDSHYC ADPAKFISVL CTSLSTMLHV ELPHVNVLSK
     MDLIEQYGKL AFNLDFYTEV LDLSYLVEHL SADPFFRNFN HLNVKLAEVI QDYSLVSFVP
     LNVQDKESMM QVLRTVDKAN GYCFGDLEER NLQAMMSAAV GADFQFSTTL GVQEKYLDAT
     KNHVEDEVMD L