ID   GPN2_XENTR              Reviewed;         303 AA.
AC   Q5BJ53;
DT   25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT   12-APR-2005, sequence version 1.
DT   03-AUG-2022, entry version 73.
DE   RecName: Full=GPN-loop GTPase 2 {ECO:0000250|UniProtKB:Q9H9Y4};
DE   AltName: Full=ATP-binding domain 1 family member B {ECO:0000250|UniProtKB:Q9H9Y4};
GN   Name=gpn2 {ECO:0000250|UniProtKB:Q9H9Y4};
GN   Synonyms=atpbd1b {ECO:0000250|UniProtKB:Q9H9Y4};
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Small GTPase required for proper localization of RNA
CC       polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly
CC       step prior to nuclear import. {ECO:0000250|UniProtKB:Q08726}.
CC   -!- SUBUNIT: Heterodimers with gpn1 or gpn3. Binds to RNA polymerase II
CC       (RNAPII). {ECO:0000250|UniProtKB:Q08726, ECO:0000250|UniProtKB:Q9H9Y4}.
CC   -!- SIMILARITY: Belongs to the GPN-loop GTPase family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC091618; AAH91618.1; -; mRNA.
DR   RefSeq; NP_001025645.1; NM_001030474.1.
DR   AlphaFoldDB; Q5BJ53; -.
DR   SMR; Q5BJ53; -.
DR   STRING; 8364.ENSXETP00000030357; -.
DR   PaxDb; Q5BJ53; -.
DR   DNASU; 595033; -.
DR   Ensembl; ENSXETT00000063399; ENSXETP00000064021; ENSXETG00000020692.
DR   GeneID; 595033; -.
DR   KEGG; xtr:595033; -.
DR   CTD; 54707; -.
DR   Xenbase; XB-GENE-5751862; gpn2.
DR   eggNOG; KOG1533; Eukaryota.
DR   HOGENOM; CLU_037460_0_2_1; -.
DR   InParanoid; Q5BJ53; -.
DR   Proteomes; UP000008143; Chromosome 2.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000020692; Expressed in 4-cell stage embryo and 13 other tissues.
DR   ExpressionAtlas; Q5BJ53; differential.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003924; F:GTPase activity; IBA:GO_Central.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR004130; Gpn.
DR   InterPro; IPR030231; Gpn2.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR21231; PTHR21231; 1.
DR   PANTHER; PTHR21231:SF3; PTHR21231:SF3; 1.
DR   Pfam; PF03029; ATP_bind_1; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
PE   2: Evidence at transcript level;
KW   GTP-binding; Hydrolase; Nucleotide-binding; Reference proteome.
FT   CHAIN           1..303
FT                   /note="GPN-loop GTPase 2"
FT                   /id="PRO_0000247834"
FT   MOTIF           85..87
FT                   /note="Gly-Pro-Asn (GPN)-loop; involved in dimer interface"
FT                   /evidence="ECO:0000250|UniProtKB:Q9UYR9"
FT   BINDING         29..34
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250|UniProtKB:Q9UYR9"
FT   BINDING         187..190
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250|UniProtKB:Q9UYR9"
FT   SITE            87
FT                   /note="Stabilizes the phosphate intermediate; shared with
FT                   dimeric partner"
FT                   /evidence="ECO:0000250|UniProtKB:Q9UYR9"
SQ   SEQUENCE   303 AA;  33754 MW;  C969BAD1FB737A20 CRC64;
     MADTDCKWDP GADKYPLLGF GQAVIGPPGS GKSTYVRAMQ ALLAQMGRKS AIINLDPAGE
     DEPGAAVSLR ELLGLEEVMS ELRLGPNGAL LYCMEYLQEN LDWLRGRLQG LRGTYFLLDC
     PGQVELYTHH PALPDVLRRL GAWGLRLCAV HLVDSHYCTD PAKFISVLCT SLSTMLHVEL
     PHINVLSKMD LIEQYGRLAF NLDYYTEVMD LSYLVEQLTS DPFFRRHKRL HEKLAEVIQD
     YGLVTFMPLS IKDEKSLRLV LSAVDKASGF CFGETKQSLG NLMSVAVGAD FQFTSYPSHD
     CRG