ID   GPN3_BOVIN              Reviewed;         284 AA.
AC   Q0P5E2;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   19-SEP-2006, sequence version 1.
DT   03-AUG-2022, entry version 91.
DE   RecName: Full=GPN-loop GTPase 3 {ECO:0000250|UniProtKB:Q9UHW5};
DE   AltName: Full=ATP-binding domain 1 family member C {ECO:0000250|UniProtKB:Q9UHW5};
GN   Name=GPN3 {ECO:0000250|UniProtKB:Q9UHW5};
GN   Synonyms=ATPBD1C {ECO:0000250|UniProtKB:Q9UHW5};
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Thymus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Small GTPase required for proper localization of RNA
CC       polymerase II (RNAPII). May act at an RNAP assembly step prior to
CC       nuclear import. {ECO:0000250|UniProtKB:Q9UHW5}.
CC   -!- SUBUNIT: Heterodimer with GPN1. Binds to RNA polymerase II (RNAPII).
CC       Interacts directly with subunits RPB4 and RPB7 and the CTD of RPB1.
CC       {ECO:0000250|UniProtKB:Q9UHW5}.
CC   -!- SIMILARITY: Belongs to the GPN-loop GTPase family. {ECO:0000305}.
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DR   EMBL; BC120171; AAI20172.1; -; mRNA.
DR   RefSeq; NP_001068740.1; NM_001075272.2.
DR   AlphaFoldDB; Q0P5E2; -.
DR   SMR; Q0P5E2; -.
DR   STRING; 9913.ENSBTAP00000007032; -.
DR   PaxDb; Q0P5E2; -.
DR   PRIDE; Q0P5E2; -.
DR   Ensembl; ENSBTAT00000007032; ENSBTAP00000007032; ENSBTAG00000005347.
DR   GeneID; 506597; -.
DR   KEGG; bta:506597; -.
DR   CTD; 51184; -.
DR   VEuPathDB; HostDB:ENSBTAG00000005347; -.
DR   VGNC; VGNC:29540; GPN3.
DR   eggNOG; KOG1534; Eukaryota.
DR   GeneTree; ENSGT00950000183172; -.
DR   HOGENOM; CLU_037460_0_0_1; -.
DR   InParanoid; Q0P5E2; -.
DR   OMA; CFEYLLQ; -.
DR   OrthoDB; 964931at2759; -.
DR   TreeFam; TF105810; -.
DR   Proteomes; UP000009136; Chromosome 17.
DR   Bgee; ENSBTAG00000005347; Expressed in oocyte and 105 other tissues.
DR   GO; GO:0032991; C:protein-containing complex; IEA:Ensembl.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003924; F:GTPase activity; IBA:GO_Central.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR004130; Gpn.
DR   InterPro; IPR030228; Gpn3.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR21231; PTHR21231; 1.
DR   PANTHER; PTHR21231:SF7; PTHR21231:SF7; 1.
DR   Pfam; PF03029; ATP_bind_1; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
PE   2: Evidence at transcript level;
KW   GTP-binding; Hydrolase; Nucleotide-binding; Reference proteome.
FT   CHAIN           1..284
FT                   /note="GPN-loop GTPase 3"
FT                   /id="PRO_0000304789"
FT   REGION          261..284
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           72..74
FT                   /note="Gly-Pro-Asn (GPN)-loop; involved in dimer interface"
FT                   /evidence="ECO:0000250|UniProtKB:Q9UYR9"
FT   BINDING         13..18
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250|UniProtKB:Q9UYR9"
FT   BINDING         174..177
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250|UniProtKB:Q9UYR9"
FT   SITE            74
FT                   /note="Stabilizes the phosphate intermediate; shared with
FT                   dimeric partner"
FT                   /evidence="ECO:0000250|UniProtKB:Q9UYR9"
SQ   SEQUENCE   284 AA;  32691 MW;  7695115663F4EE56 CRC64;
     MPRYAQLVMG PAGSGKSTYC ATMVQHCEAL NRSVQVVNLD PAAEHFNYSV MADIRELIEV
     DDVMEDSTLQ FGPNGGLVFC MEYFANNFDW LENCLGHVED DYILFDCPGQ IELYTHLPVM
     KQLVQQLEQW EFRVCGVFLV DSQFMVESFK FISGILAALS AMISLEIPQV NVMTKMDLLS
     KKAKKEIEKF LDPDMYSLLD DSTSDLRSKK FKKLTNAICG LIDDYSMVRF LPYDQSDEES
     MNIVLQHIDF AIQYGEDLEF KEPKEHEDES SSMFDEYFQE HQNE