ID   GPN3_DICDI              Reviewed;         285 AA.
AC   Q54NK8;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   03-AUG-2022, entry version 88.
DE   RecName: Full=GPN-loop GTPase 3 {ECO:0000250|UniProtKB:Q9UHW5};
DE   AltName: Full=ATP-binding domain 1 family member C homolog {ECO:0000250|UniProtKB:Q9UHW5};
GN   Name=gpn3 {ECO:0000312|dictyBase:DDB_G0285197};
GN   Synonyms=atpbd1c {ECO:0000250|UniProtKB:Q9UHW5}; ORFNames=DDB_G0285197;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Small GTPase required for proper localization of RNA
CC       polymerase II (RNAPII). May act at an RNAP assembly step prior to
CC       nuclear import. {ECO:0000250|UniProtKB:Q9UHW5}.
CC   -!- SUBUNIT: Heterodimer with gpn1. Binds to RNA polymerase II (RNAPII).
CC       {ECO:0000250|UniProtKB:Q9UHW5}.
CC   -!- SIMILARITY: Belongs to the GPN-loop GTPase family. {ECO:0000305}.
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DR   EMBL; AAFI02000075; EAL64855.1; -; Genomic_DNA.
DR   RefSeq; XP_638354.1; XM_633262.1.
DR   AlphaFoldDB; Q54NK8; -.
DR   SMR; Q54NK8; -.
DR   STRING; 44689.DDB0233478; -.
DR   PaxDb; Q54NK8; -.
DR   EnsemblProtists; EAL64855; EAL64855; DDB_G0285197.
DR   GeneID; 8624979; -.
DR   KEGG; ddi:DDB_G0285197; -.
DR   dictyBase; DDB_G0285197; gpn3.
DR   eggNOG; KOG1534; Eukaryota.
DR   HOGENOM; CLU_037460_0_0_1; -.
DR   InParanoid; Q54NK8; -.
DR   OMA; CFEYLLQ; -.
DR   PhylomeDB; Q54NK8; -.
DR   PRO; PR:Q54NK8; -.
DR   Proteomes; UP000002195; Chromosome 4.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003924; F:GTPase activity; IBA:GO_Central.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR004130; Gpn.
DR   InterPro; IPR030228; Gpn3.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR21231; PTHR21231; 1.
DR   PANTHER; PTHR21231:SF7; PTHR21231:SF7; 1.
DR   Pfam; PF03029; ATP_bind_1; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
PE   3: Inferred from homology;
KW   GTP-binding; Hydrolase; Nucleotide-binding; Reference proteome.
FT   CHAIN           1..285
FT                   /note="GPN-loop GTPase 3"
FT                   /id="PRO_0000328345"
FT   REGION          253..276
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           70..72
FT                   /note="Gly-Pro-Asn (GPN)-loop; involved in dimer interface"
FT                   /evidence="ECO:0000250|UniProtKB:Q9UYR9"
FT   COMPBIAS        260..276
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         13..18
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250|UniProtKB:Q9UYR9"
FT   BINDING         172..175
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250|UniProtKB:Q9UYR9"
FT   SITE            72
FT                   /note="Stabilizes the phosphate intermediate; shared with
FT                   dimeric partner"
FT                   /evidence="ECO:0000250|UniProtKB:Q9UYR9"
SQ   SEQUENCE   285 AA;  32514 MW;  6E79F5C88D6AA2D9 CRC64;
     MGKHVQLVMG PAGSGKSTYC DTMRKYCEEI KRSVHIVNLD PAAEVFEYPV SVDIKNLVTV
     DEVMDELHYG PNGGLVYAME YLIENMDWLT DELGDYEDDY LIIDCPGQIE LYSHIPVMRI
     LVDHLQQIGY SVCSVFLVDS QFILDNCKFI SGALMCLSAM VRLEVPHINV LTKIDVLKTS
     DQYKEIEKFL DLEVQNLVEE LNLETHDRYH RMNKAIGSLL EDFSLVGFVP LDITDQESLN
     VLLQHIDNSI QYGEDLEPKE PPLENDDDDD DDEGDEIIRM MNGNL