ID   GPN3_XENTR              Reviewed;         285 AA.
AC   Q28I42;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   04-APR-2006, sequence version 1.
DT   03-AUG-2022, entry version 83.
DE   RecName: Full=GPN-loop GTPase 3 {ECO:0000250|UniProtKB:Q9UHW5};
DE   AltName: Full=ATP-binding domain 1 family member C {ECO:0000250|UniProtKB:Q9UHW5};
GN   Name=gpn3 {ECO:0000250|UniProtKB:Q9UHW5};
GN   Synonyms=atpbd1c {ECO:0000250|UniProtKB:Q9UHW5}; ORFNames=TEgg091j20.1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Egg;
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=N6; TISSUE=Oviduct;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Small GTPase required for proper localization of RNA
CC       polymerase II (RNAPII). May act at an RNAP assembly step prior to
CC       nuclear import. {ECO:0000250|UniProtKB:Q9UHW5}.
CC   -!- SUBUNIT: Heterodimer with gpn1. Binds to RNA polymerase II (RNAPII).
CC       {ECO:0000250|UniProtKB:Q9UHW5}.
CC   -!- SIMILARITY: Belongs to the GPN-loop GTPase family. {ECO:0000305}.
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DR   EMBL; CR760599; CAJ81316.1; -; mRNA.
DR   EMBL; BC121552; AAI21553.1; -; mRNA.
DR   RefSeq; NP_001017191.1; NM_001017191.2.
DR   AlphaFoldDB; Q28I42; -.
DR   SMR; Q28I42; -.
DR   PaxDb; Q28I42; -.
DR   DNASU; 549945; -.
DR   GeneID; 549945; -.
DR   KEGG; xtr:549945; -.
DR   CTD; 51184; -.
DR   Xenbase; XB-GENE-973716; gpn3.
DR   eggNOG; KOG1534; Eukaryota.
DR   HOGENOM; CLU_037460_0_0_1; -.
DR   InParanoid; Q28I42; -.
DR   OMA; KSTYCAI; -.
DR   OrthoDB; 964931at2759; -.
DR   PhylomeDB; Q28I42; -.
DR   TreeFam; TF105810; -.
DR   Proteomes; UP000008143; Chromosome 1.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000020939; Expressed in egg cell and 13 other tissues.
DR   ExpressionAtlas; Q28I42; differential.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003924; F:GTPase activity; IBA:GO_Central.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR004130; Gpn.
DR   InterPro; IPR030228; Gpn3.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR21231; PTHR21231; 1.
DR   PANTHER; PTHR21231:SF7; PTHR21231:SF7; 1.
DR   Pfam; PF03029; ATP_bind_1; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
PE   2: Evidence at transcript level;
KW   GTP-binding; Hydrolase; Nucleotide-binding; Reference proteome.
FT   CHAIN           1..285
FT                   /note="GPN-loop GTPase 3"
FT                   /id="PRO_0000304795"
FT   REGION          261..285
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           72..74
FT                   /note="Gly-Pro-Asn (GPN)-loop; involved in dimer interface"
FT                   /evidence="ECO:0000250|UniProtKB:Q9UYR9"
FT   BINDING         13..18
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250|UniProtKB:Q9UYR9"
FT   BINDING         174..177
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250|UniProtKB:Q9UYR9"
FT   SITE            74
FT                   /note="Stabilizes the phosphate intermediate; shared with
FT                   dimeric partner"
FT                   /evidence="ECO:0000250|UniProtKB:Q9UYR9"
SQ   SEQUENCE   285 AA;  32921 MW;  E8D455AF51543E7C CRC64;
     MPRYAQLVMG PAGSGKSTYC STMVQHCGSL NRSVQVVNLD PAAEHFDYPV LADIRELIEV
     DDVMEDRSLR FGPNGGLVYC MEYFANNFDW LESCLGHTED DYILFDCPGQ IELYTHLPVM
     KYLVEQLQQW EFRVCGVFLV DSQFMVESFK FLSGVLAALS AMVSLEIPQC NIMTKMDLLG
     KKAKKEIEKF LDPDMYSMIE DTSNRFKSNK FKKLTEALCG LIDDYSMVRF LPFDRSDEEC
     MNIVLQHIDF AIQYGEDLEF KEPKENEEDK SENFDEFFQD RADEP