GPPL1_ARATH
ID GPPL1_ARATH Reviewed; 316 AA.
AC Q680K2; Q8L7U1; Q8LAS1; Q9SMQ8;
DT 13-NOV-2013, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2004, sequence version 1.
DT 03-AUG-2022, entry version 119.
DE RecName: Full=Haloacid dehalogenase-like hydrolase domain-containing protein At4g39970;
DE EC=3.1.3.-;
DE Flags: Precursor;
GN OrderedLocusNames=At4g39970; ORFNames=T5J17.140;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617198; DOI=10.1038/47134;
RA Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T.,
RA Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B.,
RA Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M.,
RA de Simone V., Obermaier B., Mache R., Mueller M., Kreis M., Delseny M.,
RA Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D.,
RA Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J.,
RA Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B.,
RA Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J.,
RA Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R.,
RA Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M.,
RA Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P.,
RA Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S.,
RA Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C.,
RA Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J.,
RA Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S.,
RA Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A.,
RA Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M.,
RA Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D.,
RA Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E.,
RA Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S.,
RA Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R.,
RA Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M.,
RA Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E.,
RA Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P.,
RA Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K.,
RA Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K.,
RA de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K.,
RA Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M.,
RA Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G.,
RA Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K.,
RA Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K.,
RA Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W.,
RA Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H.,
RA Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B.,
RA Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J.,
RA Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K.,
RA O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N.,
RA Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A.,
RA Martienssen R., McCombie W.R.;
RT "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.";
RL Nature 402:769-777(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA Feldmann K.A.;
RT "Full-length cDNA from Arabidopsis thaliana.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250};
CC -!- SUBCELLULAR LOCATION: Plastid, chloroplast {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the HAD-like hydrolase superfamily. DOG/GPP
CC family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAB38910.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=CAB80660.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AL035708; CAB38910.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AL161596; CAB80660.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002687; AEE87147.1; -; Genomic_DNA.
DR EMBL; AY127008; AAM83233.1; -; mRNA.
DR EMBL; AY143856; AAN28795.1; -; mRNA.
DR EMBL; AK175831; BAD43594.1; -; mRNA.
DR EMBL; AK175865; BAD43628.1; -; mRNA.
DR EMBL; AK176082; BAD43845.1; -; mRNA.
DR EMBL; AY087649; AAM65187.1; -; mRNA.
DR PIR; T06103; T06103.
DR RefSeq; NP_568077.1; NM_120161.3.
DR AlphaFoldDB; Q680K2; -.
DR SMR; Q680K2; -.
DR STRING; 3702.AT4G39970.1; -.
DR PaxDb; Q680K2; -.
DR PRIDE; Q680K2; -.
DR ProteomicsDB; 220639; -.
DR EnsemblPlants; AT4G39970.1; AT4G39970.1; AT4G39970.
DR GeneID; 830158; -.
DR Gramene; AT4G39970.1; AT4G39970.1; AT4G39970.
DR KEGG; ath:AT4G39970; -.
DR Araport; AT4G39970; -.
DR TAIR; locus:2140050; AT4G39970.
DR eggNOG; ENOG502QPPW; Eukaryota.
DR HOGENOM; CLU_045011_0_1_1; -.
DR InParanoid; Q680K2; -.
DR OMA; KENGWPT; -.
DR OrthoDB; 1510544at2759; -.
DR PhylomeDB; Q680K2; -.
DR PRO; PR:Q680K2; -.
DR Proteomes; UP000006548; Chromosome 4.
DR ExpressionAtlas; Q680K2; baseline and differential.
DR Genevisible; Q680K2; AT.
DR GO; GO:0009507; C:chloroplast; HDA:TAIR.
DR GO; GO:0009941; C:chloroplast envelope; HDA:TAIR.
DR GO; GO:0009570; C:chloroplast stroma; HDA:TAIR.
DR GO; GO:0005886; C:plasma membrane; HDA:TAIR.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR Gene3D; 1.10.150.240; -; 1.
DR Gene3D; 3.40.50.1000; -; 1.
DR InterPro; IPR044999; CbbY-like.
DR InterPro; IPR036412; HAD-like_sf.
DR InterPro; IPR006439; HAD-SF_hydro_IA.
DR InterPro; IPR041492; HAD_2.
DR InterPro; IPR023214; HAD_sf.
DR InterPro; IPR023198; PGP-like_dom2.
DR PANTHER; PTHR42896; PTHR42896; 1.
DR Pfam; PF13419; HAD_2; 1.
DR SUPFAM; SSF56784; SSF56784; 1.
DR TIGRFAMs; TIGR01509; HAD-SF-IA-v3; 1.
PE 2: Evidence at transcript level;
KW Chloroplast; Hydrolase; Magnesium; Metal-binding; Plastid;
KW Reference proteome; Transit peptide.
FT TRANSIT 1..46
FT /note="Chloroplast"
FT /evidence="ECO:0000255"
FT CHAIN 47..316
FT /note="Haloacid dehalogenase-like hydrolase domain-
FT containing protein At4g39970"
FT /id="PRO_0000424320"
FT ACT_SITE 69
FT /note="Nucleophile"
FT /evidence="ECO:0000250"
FT ACT_SITE 71
FT /note="Proton donor"
FT /evidence="ECO:0000250"
FT BINDING 69
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /evidence="ECO:0000250"
FT BINDING 71
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /evidence="ECO:0000250"
FT BINDING 259
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /evidence="ECO:0000250"
FT CONFLICT 51
FT /note="V -> A (in Ref. 5; AAM65187)"
FT /evidence="ECO:0000305"
FT CONFLICT 60
FT /note="L -> S (in Ref. 5; AAM65187)"
FT /evidence="ECO:0000305"
FT CONFLICT 102
FT /note="E -> A (in Ref. 5; AAM65187)"
FT /evidence="ECO:0000305"
FT CONFLICT 163
FT /note="E -> D (in Ref. 5; AAM65187)"
FT /evidence="ECO:0000305"
FT CONFLICT 213
FT /note="I -> L (in Ref. 5; AAM65187)"
FT /evidence="ECO:0000305"
FT CONFLICT 258
FT /note="E -> G (in Ref. 5; AAM65187)"
FT /evidence="ECO:0000305"
FT CONFLICT 286
FT /note="N -> D (in Ref. 5; AAM65187)"
FT /evidence="ECO:0000305"
FT CONFLICT 303
FT /note="K -> T (in Ref. 5; AAM65187)"
FT /evidence="ECO:0000305"
FT CONFLICT 306
FT /note="E -> K (in Ref. 3; AAM83233/AAN28795)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 316 AA; 34655 MW; A8940477E6673C14 CRC64;
MAVSCNHSAI LFSPSSTAGS SSVTSSSSLI GFPRFQTLRF KSRSVYSKSR VSSPVSALPL
RSLEALIFDC DGVILESENL HRQAYNDAFS HFDVRCPPSS SESLDWSLEF YDKFQNLVGG
GKPKMRWYFK ENGWPTSTIF DSPPQNDDDR AKLIDTLQDW KTERYKEIIK SGSVEPRPGV
IRLMDEAKAA GKKLAVCSAA TKSSVILCLE NLIDIERFQG LDCFLAGDDV KEKKPDPSIY
ITAAEKLGVS VKDCLVVEDS VIGLQAATKA GMSCVITYTS STSDQNFNDA IAVYPDLSNV
KLKDLETLLQ TIVTAA
