GPR15_HUMAN
ID GPR15_HUMAN Reviewed; 360 AA.
AC P49685; Q3MIL4; Q6ISN6;
DT 01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1996, sequence version 1.
DT 03-AUG-2022, entry version 164.
DE RecName: Full=G-protein coupled receptor 15;
DE AltName: Full=Brother of Bonzo;
DE Short=BoB;
GN Name=GPR15;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=8838812; DOI=10.1006/geno.1996.0143;
RA Heiber M., Marchese A., Nguyen T., Heng H.H.Q., George S.R., O'Dowd B.F.;
RT "A novel human gene encoding a G-protein-coupled receptor (GPR15) is
RT located on chromosome 3.";
RL Genomics 32:462-465(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Liver;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Probable chemokine receptor. Alternative coreceptor with CD4
CC for HIV-1 infection.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; U34806; AAC50826.1; -; Genomic_DNA.
DR EMBL; BC069437; AAH69437.1; -; mRNA.
DR EMBL; BC101779; AAI01780.1; -; mRNA.
DR EMBL; BC101781; AAI01782.1; -; mRNA.
DR CCDS; CCDS2931.1; -.
DR PIR; G02064; G02064.
DR RefSeq; NP_005281.1; NM_005290.3.
DR AlphaFoldDB; P49685; -.
DR SMR; P49685; -.
DR BioGRID; 109098; 2.
DR ELM; P49685; -.
DR STRING; 9606.ENSP00000284311; -.
DR ChEMBL; CHEMBL4523866; -.
DR GuidetoPHARMACOLOGY; 87; -.
DR iPTMnet; P49685; -.
DR PhosphoSitePlus; P49685; -.
DR BioMuta; GPR15; -.
DR DMDM; 1346170; -.
DR jPOST; P49685; -.
DR MassIVE; P49685; -.
DR PaxDb; P49685; -.
DR PeptideAtlas; P49685; -.
DR PRIDE; P49685; -.
DR ProteomicsDB; 56051; -.
DR Antibodypedia; 2944; 384 antibodies from 37 providers.
DR DNASU; 2838; -.
DR Ensembl; ENST00000284311.5; ENSP00000284311.3; ENSG00000154165.5.
DR GeneID; 2838; -.
DR KEGG; hsa:2838; -.
DR MANE-Select; ENST00000284311.5; ENSP00000284311.3; NM_005290.4; NP_005281.1.
DR UCSC; uc011bgy.3; human.
DR CTD; 2838; -.
DR DisGeNET; 2838; -.
DR GeneCards; GPR15; -.
DR HGNC; HGNC:4469; GPR15.
DR HPA; ENSG00000154165; Tissue enriched (intestine).
DR MIM; 601166; gene.
DR neXtProt; NX_P49685; -.
DR OpenTargets; ENSG00000154165; -.
DR PharmGKB; PA28858; -.
DR VEuPathDB; HostDB:ENSG00000154165; -.
DR eggNOG; ENOG502RCE3; Eukaryota.
DR GeneTree; ENSGT01050000244888; -.
DR HOGENOM; CLU_009579_8_1_1; -.
DR InParanoid; P49685; -.
DR OMA; LTFYCSI; -.
DR OrthoDB; 1201347at2759; -.
DR PhylomeDB; P49685; -.
DR TreeFam; TF330024; -.
DR PathwayCommons; P49685; -.
DR Reactome; R-HSA-418555; G alpha (s) signalling events.
DR Reactome; R-HSA-9660821; ADORA2B mediated anti-inflammatory cytokines production.
DR SignaLink; P49685; -.
DR BioGRID-ORCS; 2838; 13 hits in 1065 CRISPR screens.
DR GeneWiki; GPR15; -.
DR GenomeRNAi; 2838; -.
DR Pharos; P49685; Tbio.
DR PRO; PR:P49685; -.
DR Proteomes; UP000005640; Chromosome 3.
DR RNAct; P49685; protein.
DR Bgee; ENSG00000154165; Expressed in rectum and 72 other tissues.
DR ExpressionAtlas; P49685; baseline and differential.
DR Genevisible; P49685; HS.
DR GO; GO:0005737; C:cytoplasm; IDA:MGI.
DR GO; GO:0005768; C:endosome; IDA:UniProtKB.
DR GO; GO:0005887; C:integral component of plasma membrane; TAS:ProtInc.
DR GO; GO:0005886; C:plasma membrane; IDA:UniProtKB.
DR GO; GO:0015026; F:coreceptor activity; IDA:UniProtKB.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IDA:UniProtKB.
DR GO; GO:0001618; F:virus receptor activity; IDA:UniProtKB.
DR GO; GO:0001525; P:angiogenesis; IMP:UniProtKB.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IDA:UniProtKB.
DR GO; GO:0072678; P:T cell migration; IEA:Ensembl.
DR GO; GO:0046718; P:viral entry into host cell; IDA:UniProtKB.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR SMART; SM01381; 7TM_GPCR_Srsx; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; G-protein coupled receptor; Membrane; Receptor;
KW Reference proteome; Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..360
FT /note="G-protein coupled receptor 15"
FT /id="PRO_0000069531"
FT TOPO_DOM 1..33
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 34..54
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 55..69
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 70..90
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 91..120
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 121..141
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 142..149
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 150..170
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 171..192
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 193..213
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 214..239
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 240..260
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 261..284
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 285..305
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 306..360
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT VARIANT 37
FT /note="P -> S (in dbSNP:rs2230344)"
FT /id="VAR_020075"
FT VARIANT 112
FT /note="M -> V (in dbSNP:rs35320046)"
FT /id="VAR_049391"
SQ SEQUENCE 360 AA; 40787 MW; F781F28B7E312390 CRC64;
MDPEETSVYL DYYYATSPNS DIRETHSHVP YTSVFLPVFY TAVFLTGVLG NLVLMGALHF
KPGSRRLIDI FIINLAASDF IFLVTLPLWV DKEASLGLWR TGSFLCKGSS YMISVNMHCS
VLLLTCMSVD RYLAIVWPVV SRKFRRTDCA YVVCASIWFI SCLLGLPTLL SRELTLIDDK
PYCAEKKATP IKLIWSLVAL IFTFFVPLLS IVTCYCCIAR KLCAHYQQSG KHNKKLKKSI
KIIFIVVAAF LVSWLPFNTF KFLAIVSGLR QEHYLPSAIL QLGMEVSGPL AFANSCVNPF
IYYIFDSYIR RAIVHCLCPC LKNYDFGSST ETSDSHLTKA LSTFIHAEDF ARRRKRSVSL
