GPR15_MACFA
ID GPR15_MACFA Reviewed; 359 AA.
AC Q9BDS7;
DT 23-JAN-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 75.
DE RecName: Full=G-protein coupled receptor 15;
GN Name=GPR15;
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=11242524; DOI=10.1089/08892220150503744;
RA Wade-Evans A.M., Russell J., Jenkins A., Javan C.;
RT "Cloning and sequencing of cynomolgus macaque CCR3, GPR15, and STRL33:
RT potential coreceptors for HIV type 1, HIV type 2, and SIV.";
RL AIDS Res. Hum. Retroviruses 17:371-375(2001).
CC -!- FUNCTION: Probable chemokine receptor. SIV-1 coreceptor.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AF291670; AAK25741.1; -; mRNA.
DR AlphaFoldDB; Q9BDS7; -.
DR SMR; Q9BDS7; -.
DR STRING; 9541.XP_005548394.1; -.
DR eggNOG; ENOG502RCE3; Eukaryota.
DR Proteomes; UP000233100; Unplaced.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0001525; P:angiogenesis; ISS:UniProtKB.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; ISS:UniProtKB.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR SMART; SM01381; 7TM_GPCR_Srsx; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; G-protein coupled receptor; Membrane; Receptor;
KW Reference proteome; Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..359
FT /note="G-protein coupled receptor 15"
FT /id="PRO_0000069532"
FT TOPO_DOM 1..33
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 34..54
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 55..69
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 70..90
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 91..120
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 121..141
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 142..149
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 150..170
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 171..192
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 193..213
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 214..239
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 240..260
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 261..283
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 284..304
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 305..359
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
SQ SEQUENCE 359 AA; 40680 MW; CC2F212A94677981 CRC64;
MDPEETSVYL DYYYATSPNP DIRETHSHVP YTSVFLPVFY TAVFLTGVLG NLVLMGALHF
KPGSRRLIDI FIINLAASDF IFLVTLPLWV DKEASLGLWR TGSFLCKGSS YMISVNMHCS
VFLLTCMSVD RYLAIVCPVV SRKFRRTDCA YVVCASIWFI SCLLGLPTLL SRELTLIDDK
PYCAEKKATP LKLIWSLVAL IFTFFVPLLN IVTCYCCIAR KLCAHYQQSG RHNKKLKKSI
KIILIVVAAF LVSWLPFNTF KLLAIVSGLQ ERYFPSAMLQ LGMEVSGPLA FANSCVNPFI
YYIFDSYIRR AIVHCLCPCL KNYDFGSSTE TSDSHLTKAL STFIHAEDFT RRRKRSVSL
