ID   GPR15_MACMU             Reviewed;         360 AA.
AC   O97663; Q9TV17;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   03-AUG-2022, entry version 134.
DE   RecName: Full=G-protein coupled receptor 15;
GN   Name=GPR15;
OS   Macaca mulatta (Rhesus macaque).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9544;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   TISSUE=Spleen;
RX   PubMed=11461684; DOI=10.1089/088922201750290104;
RA   Margulies B.J., Hauer D.A., Clements J.E.;
RT   "Identification and comparison of eleven rhesus macaque chemokine
RT   receptors.";
RL   AIDS Res. Hum. Retroviruses 17:981-986(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND VARIANT ARG-28.
RX   PubMed=10408732; DOI=10.1089/088922299310665;
RA   Pretet J.-L., Brussel A., Guillet J.-G., Butor C.;
RT   "Two alleles for rhesus macaque GPR15.";
RL   AIDS Res. Hum. Retroviruses 15:945-947(1999).
CC   -!- FUNCTION: Probable chemokine receptor. SIV-1 coreceptor.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR   EMBL; AF100203; AAC72401.1; -; Genomic_DNA.
DR   EMBL; AF084226; AAD52038.1; -; mRNA.
DR   EMBL; AF084227; AAD52039.1; -; mRNA.
DR   RefSeq; NP_001036112.1; NM_001042647.1.
DR   AlphaFoldDB; O97663; -.
DR   SMR; O97663; -.
DR   STRING; 9544.ENSMMUP00000012486; -.
DR   Ensembl; ENSMMUT00000013326; ENSMMUP00000012486; ENSMMUG00000009550.
DR   GeneID; 698718; -.
DR   KEGG; mcc:698718; -.
DR   CTD; 2838; -.
DR   VEuPathDB; HostDB:ENSMMUG00000009550; -.
DR   VGNC; VGNC:73125; GPR15.
DR   eggNOG; ENOG502RCE3; Eukaryota.
DR   GeneTree; ENSGT01050000244888; -.
DR   HOGENOM; CLU_009579_8_1_1; -.
DR   InParanoid; O97663; -.
DR   OMA; LTFYCSI; -.
DR   OrthoDB; 1201347at2759; -.
DR   TreeFam; TF330024; -.
DR   Proteomes; UP000006718; Chromosome 2.
DR   Bgee; ENSMMUG00000009550; Expressed in colon and 3 other tissues.
DR   ExpressionAtlas; O97663; baseline.
DR   GO; GO:0005768; C:endosome; IEA:Ensembl.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR   GO; GO:0015026; F:coreceptor activity; IEA:Ensembl.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR   GO; GO:0001618; F:virus receptor activity; IEA:Ensembl.
DR   GO; GO:0001525; P:angiogenesis; ISS:UniProtKB.
DR   GO; GO:0007186; P:G protein-coupled receptor signaling pathway; ISS:UniProtKB.
DR   GO; GO:0072678; P:T cell migration; IEA:Ensembl.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   SMART; SM01381; 7TM_GPCR_Srsx; 1.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; G-protein coupled receptor; Membrane; Receptor;
KW   Reference proteome; Transducer; Transmembrane; Transmembrane helix.
FT   CHAIN           1..360
FT                   /note="G-protein coupled receptor 15"
FT                   /id="PRO_0000069533"
FT   TOPO_DOM        1..33
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        34..54
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        55..69
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        70..90
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        91..120
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        121..141
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        142..149
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        150..170
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        171..192
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        193..213
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        214..239
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        240..260
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        261..284
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        285..305
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        306..360
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   VARIANT         28
FT                   /note="H -> R"
FT                   /evidence="ECO:0000269|PubMed:10408732"
SQ   SEQUENCE   360 AA;  40787 MW;  ECCED1D0BC34E959 CRC64;
     MDPEETSVYL DYYYATSPNP DIRETHSHVP YTSVFLPVFY TAVFLTGVLG NLVLMGALHF
     KPGSRRLIDI FIINLAASDF IFLVTLPLWV DKEASLGLWR TGSFLCKGSS YMISVNMHCS
     VFLLTCMSVD RYLAIVCPVV SRKFRRTDCA YVVCASIWFI SCLLGLPTLL SRELTLIDDK
     PYCAEKKATP LKLIWSLVAL IFTFFVPLLS IVTCYCCIAR KLCAHYQQSG KHNKKLKKSI
     KIIFIVVAAF LVSWLPFNTF KLLAIVSGLQ QERYFPSAML QLGMEVSGPL AFANSCVNPF
     IYYIFDSYIR RAIVHCLCPC LKNYDFGSST ETSDSHLTKA LSTFIHAEDF TRRRKRSVSL