GPR15_MOUSE
ID GPR15_MOUSE Reviewed; 360 AA.
AC Q0VDU3; E9QKY6; Q3B800;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 27-JUL-2011, sequence version 2.
DT 03-AUG-2022, entry version 114.
DE RecName: Full=G-protein coupled receptor 15;
GN Name=Gpr15;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Probable chemokine receptor. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AC159200; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC107229; AAI07230.1; -; mRNA.
DR EMBL; BC107281; AAI07282.1; -; mRNA.
DR EMBL; BC107282; AAI07283.1; -; mRNA.
DR EMBL; BC119501; AAI19502.1; -; mRNA.
DR EMBL; BC119502; AAI19503.1; -; mRNA.
DR EMBL; BC119518; AAI19519.1; -; mRNA.
DR CCDS; CCDS49879.1; -.
DR RefSeq; NP_001156427.1; NM_001162955.1.
DR AlphaFoldDB; Q0VDU3; -.
DR SMR; Q0VDU3; -.
DR STRING; 10090.ENSMUSP00000086731; -.
DR PhosphoSitePlus; Q0VDU3; -.
DR PaxDb; Q0VDU3; -.
DR PRIDE; Q0VDU3; -.
DR ProteomicsDB; 271268; -.
DR Antibodypedia; 2944; 384 antibodies from 37 providers.
DR Ensembl; ENSMUST00000089318; ENSMUSP00000086731; ENSMUSG00000047293.
DR GeneID; 71223; -.
DR KEGG; mmu:71223; -.
DR UCSC; uc007zob.1; mouse.
DR CTD; 2838; -.
DR MGI; MGI:1918473; Gpr15.
DR VEuPathDB; HostDB:ENSMUSG00000047293; -.
DR eggNOG; ENOG502RCE3; Eukaryota.
DR GeneTree; ENSGT01050000244888; -.
DR HOGENOM; CLU_009579_8_1_1; -.
DR InParanoid; Q0VDU3; -.
DR OMA; LTFYCSI; -.
DR OrthoDB; 1201347at2759; -.
DR PhylomeDB; Q0VDU3; -.
DR TreeFam; TF330024; -.
DR Reactome; R-MMU-418555; G alpha (s) signalling events.
DR BioGRID-ORCS; 71223; 2 hits in 72 CRISPR screens.
DR PRO; PR:Q0VDU3; -.
DR Proteomes; UP000000589; Chromosome 16.
DR RNAct; Q0VDU3; protein.
DR Bgee; ENSMUSG00000047293; Expressed in spermatid and 13 other tissues.
DR Genevisible; Q0VDU3; MM.
DR GO; GO:0005737; C:cytoplasm; ISO:MGI.
DR GO; GO:0005768; C:endosome; ISO:MGI.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR GO; GO:0015026; F:coreceptor activity; ISO:MGI.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IMP:MGI.
DR GO; GO:0001618; F:virus receptor activity; ISO:MGI.
DR GO; GO:0001525; P:angiogenesis; ISS:UniProtKB.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; ISS:UniProtKB.
DR GO; GO:0072678; P:T cell migration; IMP:MGI.
DR GO; GO:0046718; P:viral entry into host cell; ISO:MGI.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; G-protein coupled receptor; Membrane; Receptor;
KW Reference proteome; Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..360
FT /note="G-protein coupled receptor 15"
FT /id="PRO_0000303232"
FT TOPO_DOM 1..33
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 34..54
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 55..69
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 70..90
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 91..120
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 121..141
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 142..149
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 150..170
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 171..192
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 193..213
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 214..239
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 240..260
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 261..284
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 285..305
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 306..360
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CONFLICT 22
FT /note="F -> I (in Ref. 2; AAI07230/AAI07282/AAI07283/
FT AAI19502/AAI19503/AAI19519)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 360 AA; 40542 MW; 778268073E3EFD30 CRC64;
MEPATALLIV DYYDYTSPDP PFLETPSHLS YTSVFLPIFY TVVFLTGVVG NFILMIALHF
KRGNRRLIDI FIINLAASDF IFLVTVPLWM DKEASLGLWR TGSFLCKGSS YVISVNMHCS
VFLLTCMSMD RYLAIMHPAL AKRLRRRSSA YAVCAVVWII SCVLGLPTLL SRELTHIEGK
PYCAEKKPTS LKLMWGLVAL ITTFFVPLLS IVTCYCCITR RLCAHYQQSG KHNKKLKKSI
KIVIIAVAAF TVSWVPFNTF KLLAIVSGFQ PEGLFHSEAL QLAMNVTGPL AFASSCVNPL
IYYVFDSYIR RAIVRCLCPC LKTHNFGSST ETSDSHLTKA LSNFIHAEDF IRRRKRSVSL
