GPR15_PANTR
ID GPR15_PANTR Reviewed; 360 AA.
AC Q9BG77;
DT 07-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT 21-NOV-2003, sequence version 2.
DT 03-AUG-2022, entry version 127.
DE RecName: Full=G-protein coupled receptor 15;
DE AltName: Full=Brother of Bonzo;
DE Short=BoB;
GN Name=GPR15;
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=10505680; DOI=10.1089/088922299310214;
RA Brussel A., Pretet J.-L., Girard M., Butor C.;
RT "Sequences and predicted structures of chimpanzee STRL33 (Bonzo) and gpr15
RT (BOB).";
RL AIDS Res. Hum. Retroviruses 15:1315-1319(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Yue L., Fultz P.N.;
RT "Evolution of coreceptor usage of a unique HIV-1 strain recovered from a
RT chimpanzee with AIDS.";
RL Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Probable chemokine receptor. SIV-1 coreceptor.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AF084228; AAD52040.1; -; mRNA.
DR EMBL; AF326969; AAG49591.1; -; mRNA.
DR RefSeq; NP_001009030.1; NM_001009030.1.
DR AlphaFoldDB; Q9BG77; -.
DR SMR; Q9BG77; -.
DR IntAct; Q9BG77; 1.
DR MINT; Q9BG77; -.
DR STRING; 9598.ENSPTRP00000026148; -.
DR PaxDb; Q9BG77; -.
DR Ensembl; ENSPTRT00000028335; ENSPTRP00000026148; ENSPTRG00000015150.
DR GeneID; 450102; -.
DR KEGG; ptr:450102; -.
DR CTD; 2838; -.
DR VGNC; VGNC:7971; GPR15.
DR eggNOG; ENOG502RCE3; Eukaryota.
DR GeneTree; ENSGT01050000244888; -.
DR HOGENOM; CLU_009579_8_1_1; -.
DR InParanoid; Q9BG77; -.
DR OMA; LTFYCSI; -.
DR OrthoDB; 1201347at2759; -.
DR TreeFam; TF330024; -.
DR Proteomes; UP000002277; Chromosome 3.
DR Bgee; ENSPTRG00000015150; Expressed in lymph node.
DR GO; GO:0005768; C:endosome; IEA:Ensembl.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR GO; GO:0015026; F:coreceptor activity; IEA:Ensembl.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR GO; GO:0001618; F:virus receptor activity; IEA:Ensembl.
DR GO; GO:0001525; P:angiogenesis; ISS:UniProtKB.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; ISS:UniProtKB.
DR GO; GO:0072678; P:T cell migration; IEA:Ensembl.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR SMART; SM01381; 7TM_GPCR_Srsx; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; G-protein coupled receptor; Membrane; Receptor;
KW Reference proteome; Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..360
FT /note="G-protein coupled receptor 15"
FT /id="PRO_0000069535"
FT TOPO_DOM 1..33
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 34..54
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 55..69
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 70..90
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 91..120
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 121..141
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 142..149
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 150..170
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 171..192
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 193..213
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 214..239
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 240..260
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 261..283
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 284..304
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 305..359
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CONFLICT 148
FT /note="D -> G (in Ref. 2; AAG49591)"
FT /evidence="ECO:0000305"
FT CONFLICT 212
FT /note="V -> L (in Ref. 2; AAG49591)"
FT /evidence="ECO:0000305"
FT CONFLICT 267
FT /note="S -> Y (in Ref. 2; AAG49591)"
FT /evidence="ECO:0000305"
FT CONFLICT 356
FT /note="R -> S (in Ref. 2; AAG49591)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 360 AA; 40787 MW; F781F28B7E312390 CRC64;
MDPEETSVYL DYYYATSPNS DIRETHSHVP YTSVFLPVFY TAVFLTGVLG NLVLMGALHF
KPGSRRLIDI FIINLAASDF IFLVTLPLWV DKEASLGLWR TGSFLCKGSS YMISVNMHCS
VLLLTCMSVD RYLAIVWPVV SRKFRRTDCA YVVCASIWFI SCLLGLPTLL SRELTLIDDK
PYCAEKKATP IKLIWSLVAL IFTFFVPLLS IVTCYCCIAR KLCAHYQQSG KHNKKLKKSI
KIIFIVVAAF LVSWLPFNTF KFLAIVSGLR QEHYLPSAIL QLGMEVSGPL AFANSCVNPF
IYYIFDSYIR RAIVHCLCPC LKNYDFGSST ETSDSHLTKA LSTFIHAEDF ARRRKRSVSL
