GPR17_HUMAN
ID GPR17_HUMAN Reviewed; 367 AA.
AC Q13304; A8K9L0; B2R9X0; Q8N5S7; Q9UDZ6; Q9UE21;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 27-MAY-2002, sequence version 2.
DT 03-AUG-2022, entry version 171.
DE RecName: Full=Uracil nucleotide/cysteinyl leukotriene receptor;
DE Short=UDP/CysLT receptor;
DE AltName: Full=G-protein coupled receptor 17;
DE AltName: Full=P2Y-like receptor;
DE AltName: Full=R12;
GN Name=GPR17;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 2).
RX PubMed=8558062; DOI=10.1002/jlb.59.1.18;
RA Raport C.J., Schweickart V.L., Chantry D., Eddy R.L. Jr., Shows T.B.,
RA Godiska R., Gray P.W.;
RT "New members of the chemokine receptor gene family.";
RL J. Leukoc. Biol. 59:18-23(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Hippocampus;
RX PubMed=9523551; DOI=10.1046/j.1471-4159.1998.70041357.x;
RA Blaesius R.H., Weber R.G., Lichter P., Ogilvie A.;
RT "A novel orphan G protein-coupled receptor primarily expressed in the brain
RT is localized on human chromosomal band 2q21.";
RL J. Neurochem. 70:1357-1365(1998).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Kidney;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP FUNCTION, AND TISSUE SPECIFICITY.
RX PubMed=16990797; DOI=10.1038/sj.emboj.7601341;
RA Ciana P., Fumagalli M., Trincavelli M.L., Verderio C., Rosa P., Lecca D.,
RA Ferrario S., Parravicini C., Capra V., Gelosa P., Guerrini U.,
RA Belcredito S., Cimino M., Sironi L., Tremoli E., Rovati G.E., Martini C.,
RA Abbracchio M.P.;
RT "The orphan receptor GPR17 identified as a new dual uracil
RT nucleotides/cysteinyl-leukotrienes receptor.";
RL EMBO J. 25:4615-4627(2006).
CC -!- FUNCTION: Dual specificity receptor for uracil nucleotides and
CC cysteinyl leukotrienes (CysLTs). Signals through G(i) and inhibition of
CC adenylyl cyclase. May mediate brain damage by nucleotides and CysLTs
CC following ischemia. {ECO:0000269|PubMed:16990797}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q13304-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q13304-2; Sequence=VSP_001987;
CC -!- TISSUE SPECIFICITY: Expressed in brain, kidney, heart and umbilical
CC vein endothelial cells. Highest level in brain.
CC {ECO:0000269|PubMed:16990797}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; U33447; AAB16746.1; -; Genomic_DNA.
DR EMBL; Y12546; CAA73144.1; -; mRNA.
DR EMBL; Z94154; CAB08107.1; -; mRNA.
DR EMBL; Z94155; CAB08108.1; -; mRNA.
DR EMBL; AK292725; BAF85414.1; -; mRNA.
DR EMBL; AK313949; BAG36667.1; -; mRNA.
DR EMBL; CH471103; EAW95337.1; -; Genomic_DNA.
DR EMBL; BC031653; AAH31653.1; -; mRNA.
DR EMBL; BC039595; -; NOT_ANNOTATED_CDS; mRNA.
DR CCDS; CCDS2148.1; -. [Q13304-1]
DR RefSeq; NP_001154887.1; NM_001161415.1. [Q13304-1]
DR RefSeq; NP_001154888.1; NM_001161416.1. [Q13304-2]
DR RefSeq; NP_001154889.1; NM_001161417.1. [Q13304-2]
DR RefSeq; NP_005282.1; NM_005291.2. [Q13304-1]
DR RefSeq; XP_016859322.1; XM_017003833.1. [Q13304-1]
DR AlphaFoldDB; Q13304; -.
DR SMR; Q13304; -.
DR BioGRID; 109099; 287.
DR IntAct; Q13304; 2.
DR MINT; Q13304; -.
DR STRING; 9606.ENSP00000442982; -.
DR BindingDB; Q13304; -.
DR ChEMBL; CHEMBL1075162; -.
DR DrugCentral; Q13304; -.
DR GuidetoPHARMACOLOGY; 88; -.
DR GlyGen; Q13304; 3 sites.
DR iPTMnet; Q13304; -.
DR PhosphoSitePlus; Q13304; -.
DR BioMuta; GPR17; -.
DR DMDM; 21264435; -.
DR MassIVE; Q13304; -.
DR PaxDb; Q13304; -.
DR PeptideAtlas; Q13304; -.
DR PRIDE; Q13304; -.
DR ProteomicsDB; 59291; -. [Q13304-1]
DR ProteomicsDB; 59292; -. [Q13304-2]
DR Antibodypedia; 18483; 447 antibodies from 36 providers.
DR DNASU; 2840; -.
DR Ensembl; ENST00000272644.7; ENSP00000272644.3; ENSG00000144230.17. [Q13304-1]
DR Ensembl; ENST00000393018.3; ENSP00000376741.3; ENSG00000144230.17. [Q13304-1]
DR Ensembl; ENST00000486700.2; ENSP00000508383.1; ENSG00000144230.17. [Q13304-2]
DR Ensembl; ENST00000544369.5; ENSP00000442982.1; ENSG00000144230.17. [Q13304-1]
DR GeneID; 2840; -.
DR KEGG; hsa:2840; -.
DR MANE-Select; ENST00000486700.2; ENSP00000508383.1; NM_001161417.2; NP_001154889.1. [Q13304-2]
DR UCSC; uc002tpc.4; human. [Q13304-1]
DR CTD; 2840; -.
DR DisGeNET; 2840; -.
DR GeneCards; GPR17; -.
DR HGNC; HGNC:4471; GPR17.
DR HPA; ENSG00000144230; Low tissue specificity.
DR MalaCards; GPR17; -.
DR MIM; 603071; gene.
DR neXtProt; NX_Q13304; -.
DR OpenTargets; ENSG00000144230; -.
DR PharmGKB; PA28859; -.
DR VEuPathDB; HostDB:ENSG00000144230; -.
DR eggNOG; ENOG502QW6S; Eukaryota.
DR GeneTree; ENSGT01050000244810; -.
DR HOGENOM; CLU_009579_8_2_1; -.
DR InParanoid; Q13304; -.
DR OMA; TCLNGAM; -.
DR OrthoDB; 1166460at2759; -.
DR PhylomeDB; Q13304; -.
DR TreeFam; TF330775; -.
DR PathwayCommons; Q13304; -.
DR Reactome; R-HSA-391906; Leukotriene receptors.
DR Reactome; R-HSA-416476; G alpha (q) signalling events.
DR Reactome; R-HSA-417957; P2Y receptors.
DR Reactome; R-HSA-418594; G alpha (i) signalling events.
DR SignaLink; Q13304; -.
DR SIGNOR; Q13304; -.
DR BioGRID-ORCS; 2840; 90 hits in 1063 CRISPR screens.
DR GeneWiki; GPR17; -.
DR GenomeRNAi; 2840; -.
DR Pharos; Q13304; Tchem.
DR PRO; PR:Q13304; -.
DR Proteomes; UP000005640; Chromosome 2.
DR RNAct; Q13304; protein.
DR Bgee; ENSG00000144230; Expressed in apex of heart and 111 other tissues.
DR ExpressionAtlas; Q13304; baseline and differential.
DR Genevisible; Q13304; HS.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR GO; GO:0004950; F:chemokine receptor activity; TAS:ProtInc.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR GO; GO:0033612; F:receptor serine/threonine kinase binding; IEA:Ensembl.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; TAS:ProtInc.
DR GO; GO:0002862; P:negative regulation of inflammatory response to antigenic stimulus; IEA:Ensembl.
DR GO; GO:0048709; P:oligodendrocyte differentiation; IEA:Ensembl.
DR GO; GO:0051482; P:positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway; IBA:GO_Central.
DR GO; GO:0035025; P:positive regulation of Rho protein signal transduction; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Cell membrane; Disulfide bond;
KW G-protein coupled receptor; Glycoprotein; Membrane; Receptor;
KW Reference proteome; Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..367
FT /note="Uracil nucleotide/cysteinyl leukotriene receptor"
FT /id="PRO_0000069536"
FT TOPO_DOM 1..64
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 65..85
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 86..92
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 93..113
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 114..133
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 134..154
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 155..175
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 176..196
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 197..223
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 224..244
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 245..260
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 261..281
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 282..308
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 309..329
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 330..367
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 1..28
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 42
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 204
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 282
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 132..209
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VAR_SEQ 1..28
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039,
FT ECO:0000303|PubMed:15489334, ECO:0000303|PubMed:9523551"
FT /id="VSP_001987"
FT CONFLICT 83
FT /note="L -> F (in Ref. 5; AAH31653)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 367 AA; 40989 MW; 132FBE97BE83C60C CRC64;
MSKRSWWAGS RKPPREMLKL SGSDSSQSMN GLEVAPPGLI TNFSLATAEQ CGQETPLENM
LFASFYLLDF ILALVGNTLA LWLFIRDHKS GTPANVFLMH LAVADLSCVL VLPTRLVYHF
SGNHWPFGEI ACRLTGFLFY LNMYASIYFL TCISADRFLA IVHPVKSLKL RRPLYAHLAC
AFLWVVVAVA MAPLLVSPQT VQTNHTVVCL QLYREKASHH ALVSLAVAFT FPFITTVTCY
LLIIRSLRQG LRVEKRLKTK AVRMIAIVLA IFLVCFVPYH VNRSVYVLHY RSHGASCATQ
RILALANRIT SCLTSLNGAL DPIMYFFVAE KFRHALCNLL CGKRLKGPPP SFEGKTNESS
LSAKSEL
