GPR17_MOUSE
ID GPR17_MOUSE Reviewed; 339 AA.
AC Q6NS65; Q80UD2;
DT 20-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 145.
DE RecName: Full=Uracil nucleotide/cysteinyl leukotriene receptor;
DE Short=UDP/CysLT receptor;
DE AltName: Full=G-protein coupled receptor 17;
GN Name=Gpr17 {ECO:0000312|MGI:MGI:3584514};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1] {ECO:0000312|EMBL:AAH70439.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J {ECO:0000312|EMBL:AAH70439.1};
RC TISSUE=Brain {ECO:0000312|EMBL:AAH70439.1};
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [2] {ECO:0000312|EMBL:AAO85055.1}
RP NUCLEOTIDE SEQUENCE [MRNA] OF 132-308.
RX PubMed=12679517; DOI=10.1073/pnas.0230374100;
RA Vassilatis D.K., Hohmann J.G., Zeng H., Li F., Ranchalis J.E.,
RA Mortrud M.T., Brown A., Rodriguez S.S., Weller J.R., Wright A.C.,
RA Bergmann J.E., Gaitanaris G.A.;
RT "The G protein-coupled receptor repertoires of human and mouse.";
RL Proc. Natl. Acad. Sci. U.S.A. 100:4903-4908(2003).
CC -!- FUNCTION: Dual specificity receptor for uracil nucleotides and
CC cysteinyl leukotrienes (CysLTs). Signals through G(i) and inhibition of
CC adenylyl cyclase. May mediate brain damage by nucleotides and CysLTs
CC following ischemia (By similarity). {ECO:0000250}.
CC -!- INTERACTION:
CC Q6NS65; Q99JA4: Cysltr1; NbExp=2; IntAct=EBI-15791369, EBI-15791392;
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein
CC {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; BC070439; AAH70439.1; -; mRNA.
DR EMBL; AY255543; AAO85055.1; -; mRNA.
DR CCDS; CCDS29114.1; -.
DR RefSeq; NP_001020552.1; NM_001025381.2.
DR AlphaFoldDB; Q6NS65; -.
DR SMR; Q6NS65; -.
DR BioGRID; 300034; 1.
DR DIP; DIP-48915N; -.
DR IntAct; Q6NS65; 1.
DR STRING; 10090.ENSMUSP00000063670; -.
DR BindingDB; Q6NS65; -.
DR ChEMBL; CHEMBL4295864; -.
DR DrugCentral; Q6NS65; -.
DR GuidetoPHARMACOLOGY; 88; -.
DR GlyGen; Q6NS65; 2 sites.
DR iPTMnet; Q6NS65; -.
DR PhosphoSitePlus; Q6NS65; -.
DR SwissPalm; Q6NS65; -.
DR PaxDb; Q6NS65; -.
DR PeptideAtlas; Q6NS65; -.
DR PRIDE; Q6NS65; -.
DR ProteomicsDB; 271269; -.
DR Antibodypedia; 18483; 447 antibodies from 36 providers.
DR DNASU; 574402; -.
DR Ensembl; ENSMUST00000064016; ENSMUSP00000063670; ENSMUSG00000052229.
DR GeneID; 574402; -.
DR KEGG; mmu:574402; -.
DR UCSC; uc008eiw.2; mouse.
DR CTD; 2840; -.
DR MGI; MGI:3584514; Gpr17.
DR VEuPathDB; HostDB:ENSMUSG00000052229; -.
DR eggNOG; ENOG502QW6S; Eukaryota.
DR GeneTree; ENSGT01050000244810; -.
DR HOGENOM; CLU_009579_8_2_1; -.
DR InParanoid; Q6NS65; -.
DR OMA; TCLNGAM; -.
DR OrthoDB; 1166460at2759; -.
DR PhylomeDB; Q6NS65; -.
DR TreeFam; TF330775; -.
DR Reactome; R-MMU-391906; Leukotriene receptors.
DR Reactome; R-MMU-416476; G alpha (q) signalling events.
DR Reactome; R-MMU-417957; P2Y receptors.
DR Reactome; R-MMU-418594; G alpha (i) signalling events.
DR BioGRID-ORCS; 574402; 4 hits in 72 CRISPR screens.
DR PRO; PR:Q6NS65; -.
DR Proteomes; UP000000589; Chromosome 18.
DR RNAct; Q6NS65; protein.
DR Bgee; ENSMUSG00000052229; Expressed in lumbar subsegment of spinal cord and 90 other tissues.
DR Genevisible; Q6NS65; MM.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR GO; GO:0033612; F:receptor serine/threonine kinase binding; ISO:MGI.
DR GO; GO:0002862; P:negative regulation of inflammatory response to antigenic stimulus; IMP:MGI.
DR GO; GO:0048709; P:oligodendrocyte differentiation; IEA:Ensembl.
DR GO; GO:0051482; P:positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway; IBA:GO_Central.
DR GO; GO:0035025; P:positive regulation of Rho protein signal transduction; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Receptor; Reference proteome; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..339
FT /note="Uracil nucleotide/cysteinyl leukotriene receptor"
FT /id="PRO_0000278171"
FT TOPO_DOM 1..36
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 37..57
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 58..64
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 65..85
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 86..105
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 106..126
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 127..147
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 148..168
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 169..195
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 196..216
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 217..232
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 233..253
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 254..280
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 281..301
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 302..339
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 14
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 176
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 104..181
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 339 AA; 37839 MW; 087248DC3294D0D6 CRC64;
MNGLEAALPS LTDNSSLAYS EQCGQETPLE NMLFACFYLL DFILAFVGNA LALWLFIWDH
KSGTPANVFL MHLAVADLSC VLVLPTRLVY HFSGNHWPFG EIPCRLTGFL FYLNMYASIY
FLTCISADRF LAIVHPVKSL KLRRPLYAHL ACAFLWIVVA VAMAPLLVSP QTVQTNHTVV
CLQLYREKAS HHALASLAVA FTFPFITTVT CYLLIIRSLR QGPRIEKHLK NKAVRMIAMV
LAIFLICFVP YHIHRSVYVL HYRGGGTSCA AQRALALGNR ITSCLTSLNG ALDPVMYFFV
AEKFRHALCN LLCSKRLTGP PPSFEGKTNE SSLSARSEL
