GPR17_RAT
ID GPR17_RAT Reviewed; 339 AA.
AC Q09QM4;
DT 20-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT 17-OCT-2006, sequence version 1.
DT 03-AUG-2022, entry version 109.
DE RecName: Full=Uracil nucleotide/cysteinyl leukotriene receptor;
DE Short=UDP/CysLT receptor;
DE AltName: Full=G-protein coupled receptor 17;
GN Name=Gpr17 {ECO:0000312|RGD:1589785};
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1] {ECO:0000305, ECO:0000312|EMBL:ABG75921.1}
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, AND INDUCTION.
RC STRAIN=Sprague-Dawley {ECO:0000312|EMBL:ABG75921.1};
RC TISSUE=Brain {ECO:0000312|EMBL:ABG75921.1};
RX PubMed=16990797; DOI=10.1038/sj.emboj.7601341;
RA Ciana P., Fumagalli M., Trincavelli M.L., Verderio C., Rosa P., Lecca D.,
RA Ferrario S., Parravicini C., Capra V., Gelosa P., Guerrini U.,
RA Belcredito S., Cimino M., Sironi L., Tremoli E., Rovati G.E., Martini C.,
RA Abbracchio M.P.;
RT "The orphan receptor GPR17 identified as a new dual uracil
RT nucleotides/cysteinyl-leukotrienes receptor.";
RL EMBO J. 25:4615-4627(2006).
CC -!- FUNCTION: Dual specificity receptor for uracil nucleotides and
CC cysteinyl leukotrienes (CysLTs). Signals through G(i) and inhibition of
CC adenylyl cyclase. May mediate brain damage by nucleotides and CysLTs
CC following ischemia. {ECO:0000269|PubMed:16990797}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein
CC {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed in brain, kidney, and heart. Highest
CC level in brain. {ECO:0000269|PubMed:16990797}.
CC -!- INDUCTION: In brain areas affected by ischemia.
CC {ECO:0000269|PubMed:16990797}.
CC -!- MISCELLANEOUS: Administration of an antisense oligonucleotide specific
CC for GPR17 significantly reduced brain damage following ischemia.
CC {ECO:0000269|PubMed:16990797}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; DQ777767; ABG75921.1; -; mRNA.
DR RefSeq; NP_001065245.1; NM_001071777.1.
DR RefSeq; XP_006254666.1; XM_006254604.3.
DR AlphaFoldDB; Q09QM4; -.
DR SMR; Q09QM4; -.
DR STRING; 10116.ENSRNOP00000032046; -.
DR BindingDB; Q09QM4; -.
DR ChEMBL; CHEMBL4295807; -.
DR GlyGen; Q09QM4; 2 sites.
DR PhosphoSitePlus; Q09QM4; -.
DR PaxDb; Q09QM4; -.
DR Ensembl; ENSRNOT00000104846; ENSRNOP00000091710; ENSRNOG00000065480.
DR GeneID; 767613; -.
DR KEGG; rno:767613; -.
DR UCSC; RGD:1589785; rat.
DR CTD; 2840; -.
DR RGD; 1589785; Gpr17.
DR eggNOG; ENOG502QW6S; Eukaryota.
DR GeneTree; ENSGT01050000244810; -.
DR HOGENOM; CLU_009579_8_2_1; -.
DR InParanoid; Q09QM4; -.
DR OMA; TCLNGAM; -.
DR OrthoDB; 1166460at2759; -.
DR PhylomeDB; Q09QM4; -.
DR TreeFam; TF330775; -.
DR Reactome; R-RNO-391906; Leukotriene receptors.
DR Reactome; R-RNO-416476; G alpha (q) signalling events.
DR Reactome; R-RNO-417957; P2Y receptors.
DR Reactome; R-RNO-418594; G alpha (i) signalling events.
DR PRO; PR:Q09QM4; -.
DR Proteomes; UP000002494; Chromosome 18.
DR Bgee; ENSRNOG00000025745; Expressed in frontal cortex and 13 other tissues.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR GO; GO:0033612; F:receptor serine/threonine kinase binding; IPI:RGD.
DR GO; GO:0002862; P:negative regulation of inflammatory response to antigenic stimulus; ISO:RGD.
DR GO; GO:0048709; P:oligodendrocyte differentiation; IEP:RGD.
DR GO; GO:0051482; P:positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway; IBA:GO_Central.
DR GO; GO:0035025; P:positive regulation of Rho protein signal transduction; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Receptor; Reference proteome; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..339
FT /note="Uracil nucleotide/cysteinyl leukotriene receptor"
FT /id="PRO_0000278172"
FT TOPO_DOM 1..36
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 37..57
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 58..64
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 65..85
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 86..105
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 106..126
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 127..147
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 148..168
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 169..195
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 196..216
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 217..232
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 233..253
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 254..280
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 281..301
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 302..339
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 14
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 176
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 104..181
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 339 AA; 37870 MW; 19239CC3EE0C11D7 CRC64;
MDGLETALPS LTDNASLAYS EQCGQETPLE NMLFACFYLL DFILAFVGNA LALWLFIWDH
KSGTPANVFL MHLAVADLSC VLVLPTRLVY HFSGNHWPFG EIPCRLTGFL FYLNMYASIY
FLTCISADRF LAIVHPVKSL KLRRPLYAHL ACAFLWIVVA VAMAPLLVSP QTVQTNHTVV
CLQLYREKAS HHALASLAVA FTFPFITTVT CYLLIIRSLR QGPRIEKHLK NKAVRMIAMV
LAIFLICFVP YHIHRSVYVL HYRGGGTSCS AQRALALGNR ITSCLTSLNG ALDPVMYFFV
AEKFRHALCN LLCSKRLTGP PPSFEGKTNE SSLSARSEL
