ID   GPR18_AMPAM             Reviewed;         379 AA.
AC   Q93127;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1997, sequence version 1.
DT   25-MAY-2022, entry version 95.
DE   RecName: Full=Probable G-protein coupled receptor No18;
OS   Amphibalanus amphitrite (Striped barnacle) (Balanus amphitrite).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Crustacea; Multicrustacea;
OC   Cirripedia; Thoracica; Thoracicalcarea; Balanomorpha; Balanoidea;
OC   Balanidae; Amphibalaninae; Amphibalanus.
OX   NCBI_TaxID=1232801;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Darwin;
RX   PubMed=9031635; DOI=10.1016/s0378-1119(96)00608-7;
RA   Kawahara H., Isoai A., Shizuri Y.;
RT   "Molecular cloning of a putative serotonin receptor gene from barnacle,
RT   Balanus amphitrite.";
RL   Gene 184:245-250(1997).
CC   -!- FUNCTION: Probable G-protein coupled receptor for an amine.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR   EMBL; D83547; BAA12013.1; -; Genomic_DNA.
DR   PIR; JC6178; JC6178.
DR   AlphaFoldDB; Q93127; -.
DR   SMR; Q93127; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004989; F:octopamine receptor activity; IEA:InterPro.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR002002; Octopmn_rcpt.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR00664; OCTOPAMINER.
DR   SMART; SM01381; 7TM_GPCR_Srsx; 1.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW   Membrane; Receptor; Transducer; Transmembrane; Transmembrane helix.
FT   CHAIN           1..379
FT                   /note="Probable G-protein coupled receptor No18"
FT                   /id="PRO_0000069660"
FT   TOPO_DOM        5..36
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        37..58
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        59..68
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        69..90
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        91..107
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        108..128
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        129..148
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        149..171
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        172..196
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        197..218
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        219..303
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        304..325
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        326..340
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        341..362
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        363..375
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          234..276
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        17
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        105..184
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ   SEQUENCE   379 AA;  42373 MW;  DBD483758BA953C2 CRC64;
     MSGGEASITG RTAPELNASA APLDDERELG ETVAATALLL AIILVTIVGN SLVIISVFTY
     RPLRSVQNFF VVSLAVADLT VALFVLPLNV AYRLLNQWLL GSYLCQMWLT CDILCCTSSI
     LNLCVIALDR YWAITDPINY AQKRTIRRVN TMIAAVWALS LVISVPPLLG WNDWPAQFTE
     DTPCTLTQER LFVVYSSSGS FFIPLIIMSV VYAKIFFATK RRLRERTRKL GTLAVPAPPQ
     RTSSRPLAEL ESVASQEDET EPSPEPEPLS SRADKPANGI SVHQFIEEKQ RISLSKERKA
     ARVLGVIMGV FVVCWLPFFL MYAIVPFCTN CAPPSQRVVD FVTWLGYVNS SLNPIIYTIY
     NKDFRTAFSR LLRCDRRMS