GPR19_HUMAN
ID GPR19_HUMAN Reviewed; 415 AA.
AC Q15760;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 08-FEB-2011, sequence version 2.
DT 03-AUG-2022, entry version 165.
DE RecName: Full=Probable G-protein coupled receptor 19;
DE AltName: Full=GPR-NGA;
GN Name=GPR19;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT ILE-189.
RX PubMed=8830667; DOI=10.1016/0014-5793(96)00901-5;
RA O'Dowd B.F., Nguyen T., Lynch K.R., Kolakowski L.F. Jr., Thompson M.,
RA Cheng R., Marchese A., Ng G.Y.K., Heng H.H.Q., George S.R.;
RT "A novel gene codes for a putative G protein-coupled receptor with an
RT abundant expression in brain.";
RL FEBS Lett. 394:325-329(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT ILE-189.
RA Bonner T.I., Matsuda L.A.;
RT "A G protein-coupled receptor expressed in NG108-15 and AtT-20 cells.";
RL Submitted (MAY-1996) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16541075; DOI=10.1038/nature04569;
RA Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y.,
RA Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C.,
RA Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C.,
RA Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R.,
RA Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E.,
RA Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y.,
RA Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G.,
RA Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H.,
RA Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S.,
RA Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M.,
RA Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H.,
RA Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q.,
RA Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V.,
RA Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E.,
RA Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K.,
RA Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D.,
RA Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R.,
RA David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E.,
RA D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N.,
RA Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N.,
RA Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R.,
RA Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S.,
RA LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H.,
RA Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P.,
RA Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G.,
RA Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E.,
RA Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S.,
RA Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O.,
RA Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J.,
RA Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A.,
RA Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M.,
RA Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I.,
RA Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A.,
RA Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y.,
RA Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A.,
RA Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F.,
RA Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L.,
RA Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G.,
RA Gibbs R.A.;
RT "The finished DNA sequence of human chromosome 12.";
RL Nature 440:346-351(2006).
CC -!- FUNCTION: Orphan receptor.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- TISSUE SPECIFICITY: Abundant expression in the brain.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; U64871; AAB49751.1; -; Genomic_DNA.
DR EMBL; U55312; AAB00316.1; -; Genomic_DNA.
DR EMBL; AC008115; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS8652.1; -.
DR PIR; S74237; S74237.
DR RefSeq; NP_006134.1; NM_006143.2.
DR RefSeq; XP_011518927.1; XM_011520625.2.
DR RefSeq; XP_016874705.1; XM_017019216.1.
DR AlphaFoldDB; Q15760; -.
DR SMR; Q15760; -.
DR BioGRID; 109101; 1.
DR STRING; 9606.ENSP00000441832; -.
DR ChEMBL; CHEMBL4523870; -.
DR GuidetoPHARMACOLOGY; 90; -.
DR GlyGen; Q15760; 2 sites.
DR iPTMnet; Q15760; -.
DR PhosphoSitePlus; Q15760; -.
DR BioMuta; GPR19; -.
DR DMDM; 322510031; -.
DR MassIVE; Q15760; -.
DR PaxDb; Q15760; -.
DR PeptideAtlas; Q15760; -.
DR PRIDE; Q15760; -.
DR ProteomicsDB; 60746; -.
DR Antibodypedia; 2961; 158 antibodies from 30 providers.
DR DNASU; 2842; -.
DR Ensembl; ENST00000332427.6; ENSP00000333744.2; ENSG00000183150.8.
DR Ensembl; ENST00000540510.1; ENSP00000441832.1; ENSG00000183150.8.
DR Ensembl; ENST00000651487.1; ENSP00000498976.1; ENSG00000183150.8.
DR GeneID; 2842; -.
DR KEGG; hsa:2842; -.
DR MANE-Select; ENST00000651487.1; ENSP00000498976.1; NM_006143.3; NP_006134.2.
DR UCSC; uc001raq.2; human.
DR CTD; 2842; -.
DR DisGeNET; 2842; -.
DR GeneCards; GPR19; -.
DR HGNC; HGNC:4473; GPR19.
DR HPA; ENSG00000183150; Tissue enhanced (brain, pituitary gland).
DR MalaCards; GPR19; -.
DR MIM; 602927; gene.
DR neXtProt; NX_Q15760; -.
DR OpenTargets; ENSG00000183150; -.
DR PharmGKB; PA28861; -.
DR VEuPathDB; HostDB:ENSG00000183150; -.
DR eggNOG; KOG3656; Eukaryota.
DR GeneTree; ENSGT00940000160365; -.
DR HOGENOM; CLU_009579_20_0_1; -.
DR InParanoid; Q15760; -.
DR OMA; RETFCMS; -.
DR OrthoDB; 1383895at2759; -.
DR PhylomeDB; Q15760; -.
DR TreeFam; TF331630; -.
DR PathwayCommons; Q15760; -.
DR SignaLink; Q15760; -.
DR BioGRID-ORCS; 2842; 5 hits in 1062 CRISPR screens.
DR ChiTaRS; GPR19; human.
DR GeneWiki; GPR19; -.
DR GenomeRNAi; 2842; -.
DR Pharos; Q15760; Tdark.
DR PRO; PR:Q15760; -.
DR Proteomes; UP000005640; Chromosome 12.
DR RNAct; Q15760; protein.
DR Bgee; ENSG00000183150; Expressed in Brodmann (1909) area 23 and 116 other tissues.
DR ExpressionAtlas; Q15760; baseline and differential.
DR Genevisible; Q15760; HS.
DR GO; GO:0005929; C:cilium; IDA:MGI.
DR GO; GO:0005887; C:integral component of plasma membrane; TAS:ProtInc.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR SMART; SM01381; 7TM_GPCR_Srsx; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Receptor; Reference proteome; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..415
FT /note="Probable G-protein coupled receptor 19"
FT /id="PRO_0000069538"
FT TOPO_DOM 1..69
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 70..90
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 91..102
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 103..123
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 124..143
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 144..161
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 162..182
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 183..203
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 204..221
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 222..242
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 243..277
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 278..298
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 299..309
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 310..325
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 326..415
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 25
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 52
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 138..210
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 189
FT /note="V -> I (in dbSNP:rs4763862)"
FT /evidence="ECO:0000269|PubMed:8830667, ECO:0000269|Ref.2"
FT /id="VAR_024256"
SQ SEQUENCE 415 AA; 47687 MW; D5DF78C1BFA401FD CRC64;
MVFAHRMDNS KPHLIIPTLL VPLQNRSCTE TATPLPSQYL MELSEEHSWM SNQTDLHYVL
KPGEVATASI FFGILWLFSI FGNSLVCLVI HRSRRTQSTT NYFVVSMACA DLLISVASTP
FVLLQFTTGR WTLGSATCKV VRYFQYLTPG VQIYVLLSIC IDRFYTIVYP LSFKVSREKA
KKMIAASWVF DAGFVTPVLF FYGSNWDSHC NYFLPSSWEG TAYTVIHFLV GFVIPSVLII
LFYQKVIKYI WRIGTDGRTV RRTMNIVPRT KVKTIKMFLI LNLLFLLSWL PFHVAQLWHP
HEQDYKKSSL VFTAITWISF SSSASKPTLY SIYNANFRRG MKETFCMSSM KCYRSNAYTI
TTSSRMAKKN YVGISEIPSM AKTITKDSIY DSFDREAKEK KLAWPINSNP PNTFV
