GPR19_MOUSE
ID GPR19_MOUSE Reviewed; 415 AA.
AC Q61121; Q810I4; Q8VDJ9;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 06-DEC-2005, sequence version 2.
DT 03-AUG-2022, entry version 157.
DE RecName: Full=Probable G-protein coupled receptor 19;
GN Name=Gpr19;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
RA Bonner T.I., Matsuda L.A.;
RL Submitted (APR-1996) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=C57BL/6J; TISSUE=Head, and Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=C57BL/6J, and Czech II; TISSUE=Embryo, and Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Orphan receptor.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q61121-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q61121-2; Sequence=VSP_016527;
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; U46923; AAA93354.1; -; mRNA.
DR EMBL; AK132917; BAE21421.1; -; mRNA.
DR EMBL; AK140770; BAE24474.1; -; mRNA.
DR EMBL; BC021648; AAH21648.1; -; mRNA.
DR EMBL; BC050187; AAH50187.1; -; mRNA.
DR CCDS; CCDS20641.1; -. [Q61121-2]
DR CCDS; CCDS51937.1; -. [Q61121-1]
DR RefSeq; NP_001161166.1; NM_001167694.2. [Q61121-1]
DR RefSeq; NP_001161167.1; NM_001167695.2. [Q61121-2]
DR RefSeq; NP_001161168.1; NM_001167696.2. [Q61121-2]
DR RefSeq; NP_001161169.1; NM_001167697.2. [Q61121-1]
DR RefSeq; NP_001161171.1; NM_001167699.2. [Q61121-1]
DR RefSeq; NP_001161172.1; NM_001167700.2. [Q61121-2]
DR RefSeq; NP_032183.2; NM_008157.3. [Q61121-2]
DR RefSeq; XP_006505617.1; XM_006505554.1.
DR RefSeq; XP_017176882.1; XM_017321393.1.
DR AlphaFoldDB; Q61121; -.
DR SMR; Q61121; -.
DR STRING; 10090.ENSMUSP00000047630; -.
DR GlyGen; Q61121; 2 sites.
DR PhosphoSitePlus; Q61121; -.
DR PaxDb; Q61121; -.
DR PRIDE; Q61121; -.
DR ProteomicsDB; 271270; -. [Q61121-1]
DR ProteomicsDB; 271271; -. [Q61121-2]
DR Antibodypedia; 2961; 158 antibodies from 30 providers.
DR DNASU; 14760; -.
DR Ensembl; ENSMUST00000046255; ENSMUSP00000047630; ENSMUSG00000032641. [Q61121-1]
DR Ensembl; ENSMUST00000111932; ENSMUSP00000107563; ENSMUSG00000032641. [Q61121-2]
DR Ensembl; ENSMUST00000116515; ENSMUSP00000112214; ENSMUSG00000032641. [Q61121-2]
DR Ensembl; ENSMUST00000165392; ENSMUSP00000127876; ENSMUSG00000032641. [Q61121-2]
DR GeneID; 14760; -.
DR KEGG; mmu:14760; -.
DR UCSC; uc009ekv.3; mouse. [Q61121-1]
DR UCSC; uc009eky.3; mouse. [Q61121-2]
DR CTD; 2842; -.
DR MGI; MGI:892973; Gpr19.
DR VEuPathDB; HostDB:ENSMUSG00000032641; -.
DR eggNOG; KOG3656; Eukaryota.
DR GeneTree; ENSGT00940000160365; -.
DR HOGENOM; CLU_009579_20_0_1; -.
DR InParanoid; Q61121; -.
DR OMA; RETFCMS; -.
DR PhylomeDB; Q61121; -.
DR TreeFam; TF331630; -.
DR BioGRID-ORCS; 14760; 1 hit in 75 CRISPR screens.
DR ChiTaRS; Gpr19; mouse.
DR PRO; PR:Q61121; -.
DR Proteomes; UP000000589; Chromosome 6.
DR RNAct; Q61121; protein.
DR Bgee; ENSMUSG00000032641; Expressed in spermatocyte and 230 other tissues.
DR ExpressionAtlas; Q61121; baseline and differential.
DR Genevisible; Q61121; MM.
DR GO; GO:0005929; C:cilium; IDA:MGI.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0043005; C:neuron projection; IDA:MGI.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Cell membrane; Disulfide bond;
KW G-protein coupled receptor; Glycoprotein; Membrane; Receptor;
KW Reference proteome; Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..415
FT /note="Probable G-protein coupled receptor 19"
FT /id="PRO_0000069539"
FT TOPO_DOM 1..69
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 70..90
FT /note="Helical; Name=1"
FT TOPO_DOM 91..102
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 103..123
FT /note="Helical; Name=2"
FT TOPO_DOM 124..152
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 153..173
FT /note="Helical; Name=3"
FT TOPO_DOM 174..182
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 183..203
FT /note="Helical; Name=4"
FT TOPO_DOM 204..221
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 222..242
FT /note="Helical; Name=5"
FT TOPO_DOM 243..277
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 278..298
FT /note="Helical; Name=6"
FT TOPO_DOM 299..309
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 310..332
FT /note="Helical; Name=7"
FT TOPO_DOM 333..415
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 25
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 52
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 138..210
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VAR_SEQ 1..6
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334,
FT ECO:0000303|PubMed:16141072, ECO:0000303|Ref.1"
FT /id="VSP_016527"
FT CONFLICT 26
FT /note="S -> G (in Ref. 1; AAA93354)"
FT /evidence="ECO:0000305"
FT CONFLICT 304
FT /note="D -> G (in Ref. 3; AAH50187)"
FT /evidence="ECO:0000305"
FT CONFLICT 323
FT /note="S -> P (in Ref. 3; AAH50187)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 415 AA; 47533 MW; 1904B2043DBF72D1 CRC64;
MVFAHRMDND QPPVVTATLL VPLQNSSCAE AAEALLPHGL MGLHEEHSWM SNRTELQYEL
NPGEVATASI FFGALWLFSI FGNSLVCLVI HRSRRTQSTT NYFVVSMACA DLLISVASTP
FVVLQFTTGR WTLGSAMCKV VRYFQYLTPG VQIYVLLSIC IDRFYTIVYP LSFKVSREKA
KKMIAASWIL DAAFVTPVFF FYGSNWDSHC NYFLPPSWEG TAYTVIHFLV GFVIPSILII
LFYQKVIKYI WRIGTDGRTL RRTMNIVPRT KVKTVKMFLL LNLVFLFSWL PFHVAQLWHP
HEQDYKKSSL VFTAVTWVSF SSSASKPTLY SIYNANFRRG MKETFCMSSM KCYRSNAYTI
TTSSRMAKRN YVGISEIPPV SRTITKDSIY DSFDREAREK KLAWPINSNP PNTFV
