GPR19_RAT
ID GPR19_RAT Reviewed; 415 AA.
AC P70585; Q5FVI1;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 06-DEC-2005, sequence version 2.
DT 03-AUG-2022, entry version 133.
DE RecName: Full=Probable G-protein coupled receptor 19;
GN Name=Gpr19;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 42-393.
RX PubMed=8830667; DOI=10.1016/0014-5793(96)00901-5;
RA O'Dowd B.F., Nguyen T., Lynch K.R., Kolakowski L.F. Jr., Thompson M.,
RA Cheng R., Marchese A., Ng G.Y.K., Heng H.H.Q., George S.R.;
RT "A novel gene codes for a putative G protein-coupled receptor with an
RT abundant expression in brain.";
RL FEBS Lett. 394:325-329(1996).
CC -!- FUNCTION: Orphan receptor.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- TISSUE SPECIFICITY: Abundant expression in the brain.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; BC089971; AAH89971.1; -; mRNA.
DR EMBL; U65417; AAB49752.1; -; Genomic_DNA.
DR PIR; S74238; S74238.
DR RefSeq; NP_542146.1; NM_080579.1.
DR RefSeq; XP_006237586.1; XM_006237524.2.
DR RefSeq; XP_017448148.1; XM_017592659.1.
DR RefSeq; XP_017448149.1; XM_017592660.1.
DR RefSeq; XP_017448150.1; XM_017592661.1.
DR RefSeq; XP_017448151.1; XM_017592662.1.
DR AlphaFoldDB; P70585; -.
DR SMR; P70585; -.
DR STRING; 10116.ENSRNOP00000009341; -.
DR GlyGen; P70585; 2 sites.
DR iPTMnet; P70585; -.
DR PhosphoSitePlus; P70585; -.
DR PaxDb; P70585; -.
DR PRIDE; P70585; -.
DR Ensembl; ENSRNOT00000009341; ENSRNOP00000009341; ENSRNOG00000007126.
DR Ensembl; ENSRNOT00000095765; ENSRNOP00000093658; ENSRNOG00000007126.
DR Ensembl; ENSRNOT00000116148; ENSRNOP00000085068; ENSRNOG00000007126.
DR GeneID; 312787; -.
DR KEGG; rno:312787; -.
DR UCSC; RGD:71045; rat.
DR CTD; 2842; -.
DR RGD; 71045; Gpr19.
DR eggNOG; KOG3656; Eukaryota.
DR GeneTree; ENSGT00940000160365; -.
DR HOGENOM; CLU_009579_20_0_1; -.
DR InParanoid; P70585; -.
DR OMA; RETFCMS; -.
DR OrthoDB; 1383895at2759; -.
DR PhylomeDB; P70585; -.
DR TreeFam; TF331630; -.
DR PRO; PR:P70585; -.
DR Proteomes; UP000002494; Chromosome 4.
DR Bgee; ENSRNOG00000007126; Expressed in thymus and 20 other tissues.
DR Genevisible; P70585; RN.
DR GO; GO:0005929; C:cilium; ISO:RGD.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Receptor; Reference proteome; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..415
FT /note="Probable G-protein coupled receptor 19"
FT /id="PRO_0000069540"
FT TOPO_DOM 1..69
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 70..90
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 91..102
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 103..123
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 124..152
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 153..173
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 174..182
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 183..203
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 204..221
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 222..242
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 243..277
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 278..298
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 299..309
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 310..332
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 333..415
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 25
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 52
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 138..210
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT CONFLICT 44
FT /note="H -> S (in Ref. 2; AAB49752)"
FT /evidence="ECO:0000305"
FT CONFLICT 103
FT /note="F -> L (in Ref. 2; AAB49752)"
FT /evidence="ECO:0000305"
FT CONFLICT 281
FT /note="L -> F (in Ref. 2; AAB49752)"
FT /evidence="ECO:0000305"
FT CONFLICT 304
FT /note="D -> E (in Ref. 2; AAB49752)"
FT /evidence="ECO:0000305"
FT CONFLICT 393
FT /note="F -> L (in Ref. 2; AAB49752)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 415 AA; 47634 MW; 7C20B63FF1121FB9 CRC64;
MGFDHRMETD QPPVVTATLL VPLQNGSCVE AAEALLPHGL MELHEEHSWM SNRTDLQYEL
NPGEVATASI FFGALWLFSI FGNSLVCLVI HRSRRTQSTT NYFVVSMACA DLLISVASTP
FVVLQFTTGR WTLGSAMCKV VRYFQYLTPG VQIYVLLSIC IDRFYTIVYP LSFKVSREKA
KRMIAASWIL DAAFVTPVFF FYGSNWDSHC NYFLPPSWEG TAYTVIHFLV GFVIPSVLII
LFYQKVIKYI WRIGTDGRTL RRTMNIVPRT KVKTVKMFLL LNLVFLFSWL PFHVAQLWHP
HEQDYRKSSL VFTAVTWVSF SSSASKPTLY SIYNANFRRG MKETFCMSSM KCYRSNAYTI
TTSSRMAKRN YVGISEIPPV SRTITKDSIY DSFDREAREK KLAWPINSNP PNTFV
