GPR21_HUMAN
ID GPR21_HUMAN Reviewed; 349 AA.
AC Q99679; B2R8W9; Q6NXU2;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1997, sequence version 1.
DT 03-AUG-2022, entry version 159.
DE RecName: Full=Probable G-protein coupled receptor 21;
GN Name=GPR21;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=9073069; DOI=10.1016/s0378-1119(96)00722-6;
RA O'Dowd B.F., Nguyen T., Jung B.P., Marchese A., Cheng R., Heng H.H.Q.,
RA Kolakowski L.F. Jr., Lynch K.R., George S.R.;
RT "Cloning and chromosomal mapping of four putative novel human G-protein-
RT coupled receptor genes.";
RL Gene 187:75-81(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Orphan receptor.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- TISSUE SPECIFICITY: Not detected in the brain regions thalamus,
CC putamen, caudate, frontal cortex, pons, hypothalamus, hippocampus.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; U66580; AAC51303.1; -; Genomic_DNA.
DR EMBL; AK313539; BAG36316.1; -; mRNA.
DR EMBL; CH471090; EAW87559.1; -; Genomic_DNA.
DR EMBL; BC066885; AAH66885.2; -; mRNA.
DR EMBL; BC066886; AAH66886.2; -; mRNA.
DR EMBL; BC067532; AAH67532.2; -; mRNA.
DR EMBL; BC067533; AAH67533.2; -; mRNA.
DR CCDS; CCDS6849.1; -.
DR RefSeq; NP_005285.1; NM_005294.2.
DR RefSeq; XP_005251990.1; XM_005251933.3.
DR AlphaFoldDB; Q99679; -.
DR SMR; Q99679; -.
DR BioGRID; 109103; 82.
DR IntAct; Q99679; 73.
DR STRING; 9606.ENSP00000362746; -.
DR ChEMBL; CHEMBL4523913; -.
DR GlyGen; Q99679; 2 sites.
DR iPTMnet; Q99679; -.
DR PhosphoSitePlus; Q99679; -.
DR BioMuta; GPR21; -.
DR DMDM; 2495040; -.
DR MassIVE; Q99679; -.
DR PaxDb; Q99679; -.
DR PeptideAtlas; Q99679; -.
DR PRIDE; Q99679; -.
DR ProteomicsDB; 78393; -.
DR Antibodypedia; 30412; 91 antibodies from 17 providers.
DR DNASU; 2844; -.
DR Ensembl; ENST00000616002.3; ENSP00000482287.1; ENSG00000188394.8.
DR GeneID; 2844; -.
DR KEGG; hsa:2844; -.
DR MANE-Select; ENST00000616002.3; ENSP00000482287.1; NM_005294.3; NP_005285.1.
DR UCSC; uc011lzk.3; human.
DR CTD; 2844; -.
DR DisGeNET; 2844; -.
DR GeneCards; GPR21; -.
DR HGNC; HGNC:4476; GPR21.
DR HPA; ENSG00000188394; Low tissue specificity.
DR MIM; 601909; gene.
DR neXtProt; NX_Q99679; -.
DR OpenTargets; ENSG00000188394; -.
DR PharmGKB; PA28864; -.
DR VEuPathDB; HostDB:ENSG00000188394; -.
DR eggNOG; KOG3656; Eukaryota.
DR GeneTree; ENSGT00940000163543; -.
DR HOGENOM; CLU_009579_3_3_1; -.
DR InParanoid; Q99679; -.
DR OMA; VEWRTSP; -.
DR OrthoDB; 1099557at2759; -.
DR PhylomeDB; Q99679; -.
DR TreeFam; TF332372; -.
DR PathwayCommons; Q99679; -.
DR SignaLink; Q99679; -.
DR BioGRID-ORCS; 2844; 8 hits in 1056 CRISPR screens.
DR GeneWiki; GPR21; -.
DR GenomeRNAi; 2844; -.
DR Pharos; Q99679; Tdark.
DR PRO; PR:Q99679; -.
DR Proteomes; UP000005640; Chromosome 9.
DR RNAct; Q99679; protein.
DR Bgee; ENSG00000188394; Expressed in cortical plate and 110 other tissues.
DR ExpressionAtlas; Q99679; baseline and differential.
DR Genevisible; Q99679; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0042593; P:glucose homeostasis; IEA:Ensembl.
DR GO; GO:0008286; P:insulin receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0046627; P:negative regulation of insulin receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0040018; P:positive regulation of multicellular organism growth; IEA:Ensembl.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; G-protein coupled receptor; Glycoprotein; Membrane;
KW Receptor; Reference proteome; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..349
FT /note="Probable G-protein coupled receptor 21"
FT /id="PRO_0000069542"
FT TOPO_DOM 1..32
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 33..53
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 54..75
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 76..96
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 97..104
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 105..125
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 126..147
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 148..168
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 169..191
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 192..212
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 213..252
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 253..273
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 274..283
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 284..304
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 305..349
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 2
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 8
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 349 AA; 39515 MW; 5369DFC216E9EEC4 CRC64;
MNSTLDGNQS SHPFCLLAFG YLETVNFCLL EVLIIVFLTV LIISGNIIVI FVFHCAPLLN
HHTTSYFIQT MAYADLFVGV SCVVPSLSLL HHPLPVEESL TCQIFGFVVS VLKSVSMASL
ACISIDRYIA ITKPLTYNTL VTPWRLRLCI FLIWLYSTLV FLPSFFHWGK PGYHGDVFQW
CAESWHTDSY FTLFIVMMLY APAALIVCFT YFNIFRICQQ HTKDISERQA RFSSQSGETG
EVQACPDKRY AMVLFRITSV FYILWLPYII YFLLESSTGH SNRFASFLTT WLAISNSFCN
CVIYSLSNSV FQRGLKRLSG AMCTSCASQT TANDPYTVRS KGPLNGCHI
