GPR22_HUMAN
ID GPR22_HUMAN Reviewed; 433 AA.
AC Q99680; A4D0R8; O14554;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 17-OCT-2006, sequence version 2.
DT 03-AUG-2022, entry version 162.
DE RecName: Full=G-protein coupled receptor 22;
GN Name=GPR22 {ECO:0000312|HGNC:HGNC:4477};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND TISSUE SPECIFICITY.
RX PubMed=9073069; DOI=10.1016/s0378-1119(96)00722-6;
RA O'Dowd B.F., Nguyen T., Jung B.P., Marchese A., Cheng R., Heng H.H.Q.,
RA Kolakowski L.F. Jr., Lynch K.R., George S.R.;
RT "Cloning and chromosomal mapping of four putative novel human G-protein-
RT coupled receptor genes.";
RL Gene 187:75-81(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12853948; DOI=10.1038/nature01782;
RA Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K.,
RA Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A.,
RA Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., Sun H.,
RA Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A.,
RA Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P.,
RA Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M.,
RA Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S.,
RA Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R.,
RA Strowmatt C., Latreille P., Miller N., Johnson D., Murray J.,
RA Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W.,
RA Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A.,
RA Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E.,
RA Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A.,
RA Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A.,
RA Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R.,
RA McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H.,
RA Wilson R.K.;
RT "The DNA sequence of human chromosome 7.";
RL Nature 424:157-164(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Brain;
RA Sutterer S.M., Kaighin V.A., Martin A.L., Aronstam R.S.;
RT "Isolation of cDNA coding for three human genes.";
RL Submitted (JAN-2011) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12690205; DOI=10.1126/science.1083423;
RA Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K.,
RA Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R.,
RA Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A.,
RA Kanematsu E., Gentles S., Christopoulos C.C., Choufani S., Kwasnicka D.,
RA Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S.,
RA Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R.,
RA Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N.,
RA Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E.,
RA Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R.,
RA Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T.,
RA Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W.,
RA Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A.,
RA Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X.,
RA Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E.,
RA Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H.,
RA Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J.,
RA Adams M.D., Tsui L.-C.;
RT "Human chromosome 7: DNA sequence and biology.";
RL Science 300:767-772(2003).
RN [6]
RP TISSUE SPECIFICITY, AND FUNCTION.
RX PubMed=18539757; DOI=10.1152/ajpheart.00368.2008;
RA Adams J.W., Wang J., Davis J.R., Liaw C., Gaidarov I., Gatlin J.,
RA Dalton N.D., Gu Y., Ross J. Jr., Behan D., Chien K., Connolly D.;
RT "Myocardial expression, signaling, and function of GPR22: a protective role
RT for an orphan G protein-coupled receptor.";
RL Am. J. Physiol. 295:H509-H521(2008).
CC -!- FUNCTION: Orphan G-protein coupled receptor. Seems to act through a
CC G(i)/G(o) mediated pathway (PubMed:18539757). May be involved in
CC ciliogenesis (By similarity). {ECO:0000250|UniProtKB:A0A2R9YJI3,
CC ECO:0000269|PubMed:18539757}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:D4A3U0};
CC Multi-pass membrane protein {ECO:0000255}.
CC -!- TISSUE SPECIFICITY: High expression in adult and fetal heart tissue
CC (PubMed:18539757). Expressed in the brain, with enrichment in the
CC accumbens, amygdala, cerebellum, cortex, and hippocampus regions
CC (PubMed:9073069, PubMed:18539757). {ECO:0000269|PubMed:18539757,
CC ECO:0000269|PubMed:9073069}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; U66581; AAC51304.1; -; Genomic_DNA.
DR EMBL; HQ995527; ADZ31972.1; -; mRNA.
DR EMBL; AC002381; AAB63815.1; -; Genomic_DNA.
DR EMBL; CH236947; EAL24394.1; -; Genomic_DNA.
DR EMBL; CH471070; EAW83398.1; -; Genomic_DNA.
DR CCDS; CCDS5744.1; -.
DR RefSeq; NP_005286.2; NM_005295.2.
DR RefSeq; XP_011514358.1; XM_011516056.2.
DR AlphaFoldDB; Q99680; -.
DR SMR; Q99680; -.
DR BioGRID; 109104; 3.
DR IntAct; Q99680; 4.
DR MINT; Q99680; -.
DR STRING; 9606.ENSP00000302676; -.
DR ChEMBL; CHEMBL4523914; -.
DR GlyGen; Q99680; 2 sites.
DR iPTMnet; Q99680; -.
DR PhosphoSitePlus; Q99680; -.
DR BioMuta; GPR22; -.
DR DMDM; 116242502; -.
DR MaxQB; Q99680; -.
DR PaxDb; Q99680; -.
DR PeptideAtlas; Q99680; -.
DR PRIDE; Q99680; -.
DR ProteomicsDB; 78394; -.
DR Antibodypedia; 1939; 285 antibodies from 29 providers.
DR DNASU; 2845; -.
DR Ensembl; ENST00000304402.6; ENSP00000302676.4; ENSG00000172209.6.
DR Ensembl; ENST00000639742.2; ENSP00000492841.1; ENSG00000283812.2.
DR GeneID; 2845; -.
DR KEGG; hsa:2845; -.
DR MANE-Select; ENST00000304402.6; ENSP00000302676.4; NM_005295.3; NP_005286.2.
DR UCSC; uc003vef.4; human.
DR CTD; 2845; -.
DR DisGeNET; 2845; -.
DR GeneCards; GPR22; -.
DR HGNC; HGNC:4477; GPR22.
DR HPA; ENSG00000172209; Tissue enhanced (brain, cervix, heart muscle).
DR MIM; 601910; gene.
DR neXtProt; NX_Q99680; -.
DR OpenTargets; ENSG00000172209; -.
DR PharmGKB; PA28865; -.
DR VEuPathDB; HostDB:ENSG00000172209; -.
DR eggNOG; KOG3656; Eukaryota.
DR GeneTree; ENSGT01050000244841; -.
DR HOGENOM; CLU_057984_0_0_1; -.
DR InParanoid; Q99680; -.
DR OMA; VGPSDLM; -.
DR OrthoDB; 1246385at2759; -.
DR PhylomeDB; Q99680; -.
DR TreeFam; TF318505; -.
DR PathwayCommons; Q99680; -.
DR SignaLink; Q99680; -.
DR BioGRID-ORCS; 2845; 14 hits in 1056 CRISPR screens.
DR GeneWiki; GPR22; -.
DR GenomeRNAi; 2845; -.
DR Pharos; Q99680; Tbio.
DR PRO; PR:Q99680; -.
DR Proteomes; UP000005640; Chromosome 7.
DR RNAct; Q99680; protein.
DR Bgee; ENSG00000172209; Expressed in cortical plate and 86 other tissues.
DR Genevisible; Q99680; HS.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IMP:UniProtKB.
DR GO; GO:0042277; F:peptide binding; IBA:GO_Central.
DR GO; GO:0030030; P:cell projection organization; IEA:UniProtKB-KW.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Cilium biogenesis/degradation; G-protein coupled receptor;
KW Glycoprotein; Membrane; Receptor; Reference proteome; Transducer;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..433
FT /note="G-protein coupled receptor 22"
FT /id="PRO_0000069543"
FT TOPO_DOM 1..45
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 46..66
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 67..85
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 86..106
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 107..115
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 116..136
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 137..156
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 157..177
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 178..208
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 209..229
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 230..315
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 316..336
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 337..349
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 350..370
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 371..433
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT CARBOHYD 16
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 192
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CONFLICT 425
FT /note="C -> R (in Ref. 1; AAC51304)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 433 AA; 49265 MW; 2D4DC8AC567C4DC1 CRC64;
MCFSPILEIN MQSESNITVR DDIDDINTNM YQPLSYPLSF QVSLTGFLML EIVLGLGSNL
TVLVLYCMKS NLINSVSNII TMNLHVLDVI ICVGCIPLTI VILLLSLESN TALICCFHEA
CVSFASVSTA INVFAITLDR YDISVKPANR ILTMGRAVML MISIWIFSFF SFLIPFIEVN
FFSLQSGNTW ENKTLLCVST NEYYTELGMY YHLLVQIPIF FFTVVVMLIT YTKILQALNI
RIGTRFSTGQ KKKARKKKTI SLTTQHEATD MSQSSGGRNV VFGVRTSVSV IIALRRAVKR
HRERRERQKR VFRMSLLIIS TFLLCWTPIS VLNTTILCLG PSDLLVKLRL CFLVMAYGTT
IFHPLLYAFT RQKFQKVLKS KMKKRVVSIV EADPLPNNAV IHNSWIDPKR NKKITFEDSE
IREKCLVPQV VTD
