GPR22_MOUSE
ID GPR22_MOUSE Reviewed; 432 AA.
AC Q8BZL4; Q80UE1;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 122.
DE RecName: Full=G-protein coupled receptor 22;
GN Name=Gpr22;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Diencephalon;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Pituitary;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 52-212.
RX PubMed=12679517; DOI=10.1073/pnas.0230374100;
RA Vassilatis D.K., Hohmann J.G., Zeng H., Li F., Ranchalis J.E.,
RA Mortrud M.T., Brown A., Rodriguez S.S., Weller J.R., Wright A.C.,
RA Bergmann J.E., Gaitanaris G.A.;
RT "The G protein-coupled receptor repertoires of human and mouse.";
RL Proc. Natl. Acad. Sci. U.S.A. 100:4903-4908(2003).
RN [4]
RP TISSUE SPECIFICITY, INDUCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=18539757; DOI=10.1152/ajpheart.00368.2008;
RA Adams J.W., Wang J., Davis J.R., Liaw C., Gaidarov I., Gatlin J.,
RA Dalton N.D., Gu Y., Ross J. Jr., Behan D., Chien K., Connolly D.;
RT "Myocardial expression, signaling, and function of GPR22: a protective role
RT for an orphan G protein-coupled receptor.";
RL Am. J. Physiol. 295:H509-H521(2008).
CC -!- FUNCTION: Orphan G-protein coupled receptor. Seems to act through a
CC G(i)/G(o) mediated pathway (By similarity). May be involved in
CC ciliogenesis (By similarity). {ECO:0000250|UniProtKB:A0A2R9YJI3,
CC ECO:0000250|UniProtKB:Q99680}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:D4A3U0};
CC Multi-pass membrane protein {ECO:0000255}.
CC -!- TISSUE SPECIFICITY: Abundant levels detected in the brain and heart and
CC no detectable expression in other peripheral tissues.
CC {ECO:0000269|PubMed:18539757}.
CC -!- INDUCTION: Decreased expression in heart following aortic banding, a
CC procedure that mimics cardiac hypertrophy produced by high blood
CC pressure. {ECO:0000269|PubMed:18539757}.
CC -!- DISRUPTION PHENOTYPE: No visible phenotype, however mice display
CC increased susceptibility to heart failure under conditions of
CC hemodynamic stress. {ECO:0000269|PubMed:18539757}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AK034194; BAC28626.1; -; mRNA.
DR EMBL; BC089509; AAH89509.1; -; mRNA.
DR EMBL; AY255527; AAO85039.1; -; mRNA.
DR CCDS; CCDS25866.3; -.
DR RefSeq; NP_780400.2; NM_175191.4.
DR AlphaFoldDB; Q8BZL4; -.
DR SMR; Q8BZL4; -.
DR STRING; 10090.ENSMUSP00000056125; -.
DR GlyGen; Q8BZL4; 2 sites.
DR iPTMnet; Q8BZL4; -.
DR PhosphoSitePlus; Q8BZL4; -.
DR PaxDb; Q8BZL4; -.
DR PRIDE; Q8BZL4; -.
DR ProteomicsDB; 271450; -.
DR Antibodypedia; 1939; 285 antibodies from 29 providers.
DR DNASU; 73010; -.
DR Ensembl; ENSMUST00000057783; ENSMUSP00000056125; ENSMUSG00000044067.
DR Ensembl; ENSMUST00000176710; ENSMUSP00000134839; ENSMUSG00000044067.
DR GeneID; 73010; -.
DR KEGG; mmu:73010; -.
DR CTD; 2845; -.
DR MGI; MGI:1920260; Gpr22.
DR VEuPathDB; HostDB:ENSMUSG00000044067; -.
DR eggNOG; KOG3656; Eukaryota.
DR GeneTree; ENSGT01050000244841; -.
DR HOGENOM; CLU_057984_0_0_1; -.
DR InParanoid; Q8BZL4; -.
DR OMA; VGPSDLM; -.
DR OrthoDB; 1246385at2759; -.
DR BioGRID-ORCS; 73010; 1 hit in 58 CRISPR screens.
DR ChiTaRS; Gpr22; mouse.
DR PRO; PR:Q8BZL4; -.
DR Proteomes; UP000000589; Chromosome 12.
DR RNAct; Q8BZL4; protein.
DR Bgee; ENSMUSG00000044067; Expressed in subiculum and 95 other tissues.
DR ExpressionAtlas; Q8BZL4; baseline and differential.
DR Genevisible; Q8BZL4; MM.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR GO; GO:0004930; F:G protein-coupled receptor activity; ISS:UniProtKB.
DR GO; GO:0042277; F:peptide binding; IBA:GO_Central.
DR GO; GO:0030030; P:cell projection organization; IEA:UniProtKB-KW.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Cilium biogenesis/degradation; G-protein coupled receptor;
KW Glycoprotein; Membrane; Receptor; Reference proteome; Transducer;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..432
FT /note="G-protein coupled receptor 22"
FT /id="PRO_0000303235"
FT TOPO_DOM 1..45
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 46..66
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 67..85
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 86..106
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 107..115
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 116..136
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 137..156
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 157..177
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 178..208
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 209..229
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 230..314
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 315..335
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 336..348
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 349..369
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 370..432
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT CARBOHYD 16
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 192
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 432 AA; 49019 MW; 5321177CBDF00BB4 CRC64;
MCFSPVLEIN MQSESNVTVR DDIDDIDTNM YQPLSYPLSF QVSLTGFLML EIVLGLGSNL
TVLVLYCMKS NLINSVSNII TMNLHVLDVI ICVGCIPLTI VILLLSLESN TALICCFHEA
CVSFASVSTA INVFAITLDR YDISVKPANR ILTMGRAVML MTSIWIFSFF SFLIPFIEVN
FFSLQSGNTW ANKTLLCVST SEYYTELGMY YHLLVQIPIF FFTVIVMLIT YTKILQALNI
RIGTRFSTGQ KKKARKKKTI SLATHETTDM SQSSGGRNVV FGVRTSVSVI IALRRAVKRH
RERRERQKRV FKMSLLIIST FLLCWTPISV LNTTILCLGP SDLLVKLRLC FLVMAYGTTI
FHPLLYAFTR QKFQKVLKSK MKKRVVSIVE ADPMPNNAVI HNSWIDPKRN KKVTYEDSEI
REKCLVPQVV TD
