GPR22_RAT
ID GPR22_RAT Reviewed; 432 AA.
AC D4A3U0;
DT 10-OCT-2018, integrated into UniProtKB/Swiss-Prot.
DT 10-OCT-2018, sequence version 2.
DT 03-AUG-2022, entry version 80.
DE RecName: Full=G-protein coupled receptor 22;
GN Name=Gpr22 {ECO:0000312|RGD:1310848};
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Brown Norway;
RX PubMed=15057822; DOI=10.1038/nature02426;
RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA Mockrin S., Collins F.S.;
RT "Genome sequence of the Brown Norway rat yields insights into mammalian
RT evolution.";
RL Nature 428:493-521(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP TISSUE SPECIFICITY, AND SUBCELLULAR LOCATION.
RX PubMed=18539757; DOI=10.1152/ajpheart.00368.2008;
RA Adams J.W., Wang J., Davis J.R., Liaw C., Gaidarov I., Gatlin J.,
RA Dalton N.D., Gu Y., Ross J. Jr., Behan D., Chien K., Connolly D.;
RT "Myocardial expression, signaling, and function of GPR22: a protective role
RT for an orphan G protein-coupled receptor.";
RL Am. J. Physiol. 295:H509-H521(2008).
CC -!- FUNCTION: Orphan G-protein coupled receptor. Seems to act through a
CC G(i)/G(o) mediated pathway (By similarity). May be involved in
CC ciliogenesis (By similarity). {ECO:0000250|UniProtKB:A0A2R9YJI3,
CC ECO:0000250|UniProtKB:Q99680}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:18539757};
CC Multi-pass membrane protein {ECO:0000255}.
CC -!- TISSUE SPECIFICITY: Abundant levels detected in the brain
CC (PubMed:18539757). High expression in the heart (at protein level)
CC (PubMed:18539757). No detectable expression in other peripheral tissues
CC (PubMed:18539757). {ECO:0000269|PubMed:18539757}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- SEQUENCE CAUTION:
CC Sequence=EDM03260.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AABR07063821; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH473947; EDM03260.1; ALT_INIT; Genomic_DNA.
DR RefSeq; NP_001100192.1; NM_001106722.1.
DR RefSeq; XP_017449568.1; XM_017594079.1.
DR AlphaFoldDB; D4A3U0; -.
DR SMR; D4A3U0; -.
DR STRING; 10116.ENSRNOP00000011659; -.
DR PhosphoSitePlus; D4A3U0; -.
DR PaxDb; D4A3U0; -.
DR GeneID; 298944; -.
DR KEGG; rno:298944; -.
DR UCSC; RGD:1310848; rat.
DR CTD; 2845; -.
DR RGD; 1310848; Gpr22.
DR eggNOG; KOG3656; Eukaryota.
DR InParanoid; D4A3U0; -.
DR OrthoDB; 871605at2759; -.
DR PhylomeDB; D4A3U0; -.
DR TreeFam; TF318505; -.
DR PRO; PR:D4A3U0; -.
DR Proteomes; UP000002494; Unplaced.
DR Proteomes; UP000234681; Chromosome 6.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IDA:UniProtKB.
DR GO; GO:0004930; F:G protein-coupled receptor activity; ISS:UniProtKB.
DR GO; GO:0042277; F:peptide binding; IBA:GO_Central.
DR GO; GO:0030030; P:cell projection organization; IEA:UniProtKB-KW.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Cilium biogenesis/degradation; Membrane; Receptor;
KW Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..432
FT /note="G-protein coupled receptor 22"
FT /id="PRO_0000445472"
FT TOPO_DOM 1..45
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 46..66
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 67..85
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 86..106
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 107..115
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 116..136
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 137..156
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 157..177
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 178..208
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 209..229
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 230..314
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 315..335
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 336..348
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 349..369
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 370..432
FT /note="Extracellular"
FT /evidence="ECO:0000305"
SQ SEQUENCE 432 AA; 49133 MW; D742FEE726EA1391 CRC64;
MCFSPVLEIN MQSESNVTVR DDIEDIDTNM YQPLSYPLSF QVSLTGFLML EIVLGLGSNL
TVLVLYCMKS NLISSVSNII TMNLHVLDVI ICVGCIPLTI VILLLSLERN TALICCFHEA
CVSFASVSTA INVFAITLDR YDISVKPANR ILTMGRAVML MTSIWIFSFF SFLIPFIEVN
FFSLQSGNAW ENKTLLCVST SEYYTELGMY YHLLVQIPIF FFTVIVMLIT YTKILQALNI
RIGTRFSTGQ KKKARKKKTI SLTTHETTDM SQSSGGRNVV FGVRTSVSVI IALRRAVKRH
RERRERQKRV FKMSLLIIST FLLCWTPISV LNTTILCLGP SDLLVKLRLC FLVMAYGTTI
FHPLLYAFTR QKFQKVLKSK MKKRVVSIVE ADPMPNNAVI HNSWIDPKRN KKVTYEDSEI
REKCLVPQVV TD
