GPR25_HUMAN
ID GPR25_HUMAN Reviewed; 361 AA.
AC O00155; A0AVJ5;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 10-MAY-2004, sequence version 2.
DT 03-AUG-2022, entry version 163.
DE RecName: Full=Probable G-protein coupled receptor 25;
GN Name=GPR25;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=9020062; DOI=10.1006/bbrc.1996.5828;
RA Jung B.P., Nguyen T., Kolakowski L.F. Jr., Lynch K.R., Heng H.H.Q.,
RA George S.R., O'Dowd B.F.;
RT "Discovery of a novel human G protein-coupled receptor gene (GPR25) located
RT on chromosome 1.";
RL Biochem. Biophys. Res. Commun. 230:69-72(1997).
RN [2]
RP SEQUENCE REVISION TO 101-104; 116; 124 AND 157.
RA Jung B.P., Nguyen T., Kolakowski L.F. Jr., Lynch K.R., Heng H.H.Q.,
RA George S.R., O'Dowd B.F.;
RL Submitted (NOV-2003) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Orphan receptor.
CC -!- INTERACTION:
CC O00155; Q13520: AQP6; NbExp=3; IntAct=EBI-10178951, EBI-13059134;
CC O00155; P27449: ATP6V0C; NbExp=3; IntAct=EBI-10178951, EBI-721179;
CC O00155; O15342: ATP6V0E1; NbExp=3; IntAct=EBI-10178951, EBI-12935759;
CC O00155; Q8NFU1: BEST2; NbExp=3; IntAct=EBI-10178951, EBI-19947314;
CC O00155; Q9P003: CNIH4; NbExp=3; IntAct=EBI-10178951, EBI-1044341;
CC O00155; Q96BA8: CREB3L1; NbExp=7; IntAct=EBI-10178951, EBI-6942903;
CC O00155; Q68CJ9: CREB3L3; NbExp=3; IntAct=EBI-10178951, EBI-852194;
CC O00155; Q969F0: FATE1; NbExp=5; IntAct=EBI-10178951, EBI-743099;
CC O00155; Q9UJ14: GGT7; NbExp=6; IntAct=EBI-10178951, EBI-1058791;
CC O00155; P08034: GJB1; NbExp=3; IntAct=EBI-10178951, EBI-17565645;
CC O00155; Q70UQ0-4: IKBIP; NbExp=3; IntAct=EBI-10178951, EBI-12190633;
CC O00155; Q8N6L0: KASH5; NbExp=6; IntAct=EBI-10178951, EBI-749265;
CC O00155; Q5T700: LDLRAD1; NbExp=3; IntAct=EBI-10178951, EBI-10173166;
CC O00155; Q6N075: MFSD5; NbExp=3; IntAct=EBI-10178951, EBI-3920969;
CC O00155; Q8N4V1: MMGT1; NbExp=3; IntAct=EBI-10178951, EBI-6163737;
CC O00155; Q58DX5: NAALADL2; NbExp=3; IntAct=EBI-10178951, EBI-10178964;
CC O00155; Q8ND90: PNMA1; NbExp=3; IntAct=EBI-10178951, EBI-302345;
CC O00155; Q9HD89: RETN; NbExp=5; IntAct=EBI-10178951, EBI-12384280;
CC O00155; Q9UBD6: RHCG; NbExp=3; IntAct=EBI-10178951, EBI-15853497;
CC O00155; Q3SXP7: SHISAL1; NbExp=3; IntAct=EBI-10178951, EBI-18037857;
CC O00155; O60669: SLC16A7; NbExp=3; IntAct=EBI-10178951, EBI-3921243;
CC O00155; Q7Z769: SLC35E3; NbExp=3; IntAct=EBI-10178951, EBI-13389236;
CC O00155; Q96BD0: SLCO4A1; NbExp=3; IntAct=EBI-10178951, EBI-2822217;
CC O00155; P27105: STOM; NbExp=3; IntAct=EBI-10178951, EBI-1211440;
CC O00155; Q96Q45-2: TMEM237; NbExp=3; IntAct=EBI-10178951, EBI-10982110;
CC O00155; Q9NWD8: TMEM248; NbExp=3; IntAct=EBI-10178951, EBI-10314986;
CC O00155; Q4KMG9: TMEM52B; NbExp=3; IntAct=EBI-10178951, EBI-18178701;
CC O00155; Q86W33-2: TPRA1; NbExp=3; IntAct=EBI-10178951, EBI-18976295;
CC O00155; O95859: TSPAN12; NbExp=3; IntAct=EBI-10178951, EBI-2466403;
CC O00155; O95292: VAPB; NbExp=3; IntAct=EBI-10178951, EBI-1188298;
CC O00155; Q53XM7: VAPB; NbExp=3; IntAct=EBI-10178951, EBI-10178947;
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; U91939; AAB50155.2; -; Genomic_DNA.
DR EMBL; BC126386; AAI26387.1; -; mRNA.
DR EMBL; BC126388; AAI26389.1; -; mRNA.
DR CCDS; CCDS1405.1; -.
DR PIR; JC5277; JC5277.
DR RefSeq; NP_005289.2; NM_005298.3.
DR AlphaFoldDB; O00155; -.
DR SMR; O00155; -.
DR BioGRID; 109107; 31.
DR IntAct; O00155; 31.
DR STRING; 9606.ENSP00000301917; -.
DR ChEMBL; CHEMBL4523858; -.
DR iPTMnet; O00155; -.
DR PhosphoSitePlus; O00155; -.
DR BioMuta; GPR25; -.
DR PaxDb; O00155; -.
DR PeptideAtlas; O00155; -.
DR PRIDE; O00155; -.
DR ProteomicsDB; 47743; -.
DR Antibodypedia; 20636; 179 antibodies from 26 providers.
DR DNASU; 2848; -.
DR Ensembl; ENST00000304244.5; ENSP00000301917.2; ENSG00000170128.5.
DR GeneID; 2848; -.
DR KEGG; hsa:2848; -.
DR MANE-Select; ENST00000304244.5; ENSP00000301917.2; NM_005298.4; NP_005289.2.
DR UCSC; uc001gvn.3; human.
DR CTD; 2848; -.
DR DisGeNET; 2848; -.
DR GeneCards; GPR25; -.
DR HGNC; HGNC:4480; GPR25.
DR HPA; ENSG00000170128; Tissue enriched (stomach).
DR MIM; 602174; gene.
DR neXtProt; NX_O00155; -.
DR OpenTargets; ENSG00000170128; -.
DR PharmGKB; PA28868; -.
DR VEuPathDB; HostDB:ENSG00000170128; -.
DR eggNOG; KOG3656; Eukaryota.
DR GeneTree; ENSGT01050000244888; -.
DR HOGENOM; CLU_009579_8_1_1; -.
DR InParanoid; O00155; -.
DR OMA; GGHGSQC; -.
DR OrthoDB; 1226574at2759; -.
DR PhylomeDB; O00155; -.
DR TreeFam; TF330024; -.
DR PathwayCommons; O00155; -.
DR Reactome; R-HSA-418555; G alpha (s) signalling events.
DR Reactome; R-HSA-9660821; ADORA2B mediated anti-inflammatory cytokines production.
DR SignaLink; O00155; -.
DR BioGRID-ORCS; 2848; 14 hits in 1058 CRISPR screens.
DR GeneWiki; GPR25; -.
DR GenomeRNAi; 2848; -.
DR Pharos; O00155; Tdark.
DR PRO; PR:O00155; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; O00155; protein.
DR Bgee; ENSG00000170128; Expressed in granulocyte and 49 other tissues.
DR Genevisible; O00155; HS.
DR GO; GO:0005887; C:integral component of plasma membrane; TAS:ProtInc.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 1: Evidence at protein level;
KW Cell membrane; G-protein coupled receptor; Membrane; Receptor;
KW Reference proteome; Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..361
FT /note="Probable G-protein coupled receptor 25"
FT /id="PRO_0000069544"
FT TOPO_DOM 1..39
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 40..60
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 61..75
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 76..96
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 97..126
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 127..147
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 148..155
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 156..176
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 177..200
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 201..220
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 221..242
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 243..263
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 264..289
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 290..310
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 311..361
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
SQ SEQUENCE 361 AA; 38779 MW; C9C155A415B1DE9F CRC64;
MAPTEPWSPS PGSAPWDYSG LDGLEELELC PAGDLPYGYV YIPALYLAAF AVGLLGNAFV
VWLLAGRRGP RRLVDTFVLH LAAADLGFVL TLPLWAAAAA LGGRWPFGDG LCKLSSFALA
GTRCAGALLL AGMSVDRYLA VVKLLEARPL RTPRCALASC CGVWAVALLA GLPSLVYRGL
QPLPGGQDSQ CGEEPSHAFQ GLSLLLLLLT FVLPLVVTLF CYCRISRRLR RPPHVGRARR
NSLRIIFAIE STFVGSWLPF SALRAVFHLA RLGALPLPCP LLLALRWGLT IATCLAFVNS
CANPLIYLLL DRSFRARALD GACGRTGRLA RRISSASSLS RDDSSVFRCR AQAANTASAS
W
