GPR25_MOUSE
ID GPR25_MOUSE Reviewed; 358 AA.
AC P0C5I1;
DT 02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 02-OCT-2007, sequence version 1.
DT 03-AUG-2022, entry version 94.
DE RecName: Full=Probable G-protein coupled receptor 25;
GN Name=Gpr25; Synonyms=Gm1300;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
CC -!- FUNCTION: Orphan receptor.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AC124550; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS48381.1; -.
DR RefSeq; NP_001094986.1; NM_001101516.1.
DR AlphaFoldDB; P0C5I1; -.
DR SMR; P0C5I1; -.
DR STRING; 10090.ENSMUSP00000083583; -.
DR PhosphoSitePlus; P0C5I1; -.
DR PaxDb; P0C5I1; -.
DR PRIDE; P0C5I1; -.
DR ProteomicsDB; 271039; -.
DR Antibodypedia; 20636; 179 antibodies from 26 providers.
DR Ensembl; ENSMUST00000086395; ENSMUSP00000083583; ENSMUSG00000052759.
DR GeneID; 383563; -.
DR KEGG; mmu:383563; -.
DR UCSC; uc011wsy.1; mouse.
DR CTD; 2848; -.
DR MGI; MGI:2686146; Gpr25.
DR VEuPathDB; HostDB:ENSMUSG00000052759; -.
DR eggNOG; KOG3656; Eukaryota.
DR GeneTree; ENSGT01050000244888; -.
DR HOGENOM; CLU_009579_8_1_1; -.
DR InParanoid; P0C5I1; -.
DR OMA; GGHGSQC; -.
DR OrthoDB; 1226574at2759; -.
DR PhylomeDB; P0C5I1; -.
DR TreeFam; TF330024; -.
DR Reactome; R-MMU-418555; G alpha (s) signalling events.
DR BioGRID-ORCS; 383563; 5 hits in 71 CRISPR screens.
DR PRO; PR:P0C5I1; -.
DR Proteomes; UP000000589; Chromosome 1.
DR RNAct; P0C5I1; protein.
DR Bgee; ENSMUSG00000052759; Expressed in prefrontal cortex and 37 other tissues.
DR Genevisible; P0C5I1; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Disulfide bond; G-protein coupled receptor; Membrane; Receptor;
KW Reference proteome; Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..358
FT /note="Probable G-protein coupled receptor 25"
FT /id="PRO_0000307093"
FT TOPO_DOM 1..43
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 44..64
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 65..76
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 77..97
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 98..113
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 114..134
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 135..155
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 156..176
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 177..200
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 201..221
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 222..239
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 240..260
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 261..284
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 285..307
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 308..358
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 339..358
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 112..191
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 358 AA; 38754 MW; 2A7F7D925F4A3E73 CRC64;
MQSTEPWSPS WGTLSWDYSG SGSLDQVELC PAWNLPYGHA IIPALYLAAF AVGLPGNAFV
VWLLSRQRGP RRLVDTFVLH LAAADLGFVL TLPLWAAAEA RGGLWPFGDG LCKVSSFALA
VTRCAGALLL AGMSVDRYLA VGRPLSARPL RSARCVRAVC GAAWAAAFLA GLPALLYRGL
QPSLDGVGSQ CAEEPWEALQ GVGLLLLLLT FALPLAVTLI CYWRVSRRLP RVGRARSNSL
RIIFTVESVF VGCWLPFGVL RSLFHLARLQ ALPLPCSLLL ALRWGLTVTT CLAFVNSSAN
PVIYLLLDRS FRARARFGLC ARAGRQVRRI SSASSLSRDD SSVFRGRSPK VNSASATW
