GPR26_HUMAN
ID GPR26_HUMAN Reviewed; 337 AA.
AC Q8NDV2; Q2M2E2;
DT 03-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 139.
DE RecName: Full=G-protein coupled receptor 26;
GN Name=GPR26;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Brain;
RA Jones G., Boulay J.L., Maier D., Merlo A.;
RT "Sequence of the human homologue of the rat orphan G protein-coupled
RT receptor GPR26 mRNA.";
RL Submitted (AUG-2002) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Brain;
RA Boulay J.L., Labuhn M., Jones G., Maier D., Merlo A.;
RT "The 10q25.3-26.1 gene encoding the orphan G protein-coupled receptor GPR26
RT is epigenetically silenced in human gliomas.";
RL Submitted (AUG-2002) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP FUNCTION, TISSUE SPECIFICITY, AND MUTAGENESIS OF ARG-104 AND ARG-236.
RX PubMed=17363172; DOI=10.1016/j.bbagen.2007.01.013;
RA Jones P.G., Nawoschik S.P., Sreekumar K., Uveges A.J., Tseng E., Zhang L.,
RA Johnson J., He L., Paulsen J.E., Bates B., Pausch M.H.;
RT "Tissue distribution and functional analyses of the constitutively active
RT orphan G protein coupled receptors, GPR26 and GPR78.";
RL Biochim. Biophys. Acta 1770:890-901(2007).
RN [5]
RP TISSUE SPECIFICITY.
RX PubMed=18037267; DOI=10.1016/j.mcp.2007.10.002;
RA Carter A.N., Cole C.L., Playle A.G., Ramsay E.J., Shervington A.A.;
RT "GPR26: a marker for primary glioblastoma?";
RL Mol. Cell. Probes 22:133-137(2008).
CC -!- FUNCTION: Orphan receptor. Displays a significant level of constitutive
CC activity. Its effect is mediated by G(s)-alpha protein that stimulate
CC adenylate cyclase, resulting in an elevation of intracellular cAMP.
CC {ECO:0000269|PubMed:17363172}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- TISSUE SPECIFICITY: Highly expressed in the CNS, the highest expression
CC is seen in the amygdala, hippocampus and thalamus. Weak expression is
CC detected in testis. Down-regulated in glioblastoma.
CC {ECO:0000269|PubMed:17363172, ECO:0000269|PubMed:18037267}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AJ505757; CAD44281.1; -; mRNA.
DR EMBL; BC112011; AAI12012.1; -; mRNA.
DR EMBL; BC113462; AAI13463.1; -; mRNA.
DR CCDS; CCDS7636.1; -.
DR RefSeq; NP_703143.1; NM_153442.3.
DR AlphaFoldDB; Q8NDV2; -.
DR SMR; Q8NDV2; -.
DR BioGRID; 109108; 1.
DR CORUM; Q8NDV2; -.
DR STRING; 9606.ENSP00000284674; -.
DR ChEMBL; CHEMBL4523895; -.
DR BioMuta; GPR26; -.
DR DMDM; 37537804; -.
DR MassIVE; Q8NDV2; -.
DR PaxDb; Q8NDV2; -.
DR PeptideAtlas; Q8NDV2; -.
DR PRIDE; Q8NDV2; -.
DR ProteomicsDB; 73057; -.
DR Antibodypedia; 19086; 174 antibodies from 27 providers.
DR DNASU; 2849; -.
DR Ensembl; ENST00000284674.2; ENSP00000284674.1; ENSG00000154478.4.
DR GeneID; 2849; -.
DR KEGG; hsa:2849; -.
DR MANE-Select; ENST00000284674.2; ENSP00000284674.1; NM_153442.4; NP_703143.1.
DR UCSC; uc001lhh.4; human.
DR CTD; 2849; -.
DR DisGeNET; 2849; -.
DR GeneCards; GPR26; -.
DR HGNC; HGNC:4481; GPR26.
DR HPA; ENSG00000154478; Tissue enriched (brain).
DR MIM; 604847; gene.
DR neXtProt; NX_Q8NDV2; -.
DR OpenTargets; ENSG00000154478; -.
DR PharmGKB; PA28869; -.
DR VEuPathDB; HostDB:ENSG00000154478; -.
DR eggNOG; KOG3656; Eukaryota.
DR GeneTree; ENSGT00950000183001; -.
DR HOGENOM; CLU_009579_3_5_1; -.
DR InParanoid; Q8NDV2; -.
DR OMA; HQYKKTW; -.
DR OrthoDB; 1039292at2759; -.
DR PhylomeDB; Q8NDV2; -.
DR TreeFam; TF332434; -.
DR PathwayCommons; Q8NDV2; -.
DR BioGRID-ORCS; 2849; 10 hits in 1061 CRISPR screens.
DR ChiTaRS; GPR26; human.
DR GeneWiki; GPR26; -.
DR GenomeRNAi; 2849; -.
DR Pharos; Q8NDV2; Tbio.
DR PRO; PR:Q8NDV2; -.
DR Proteomes; UP000005640; Chromosome 10.
DR RNAct; Q8NDV2; protein.
DR Bgee; ENSG00000154478; Expressed in endothelial cell and 103 other tissues.
DR Genevisible; Q8NDV2; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IDA:UniProtKB.
DR GO; GO:0007189; P:adenylate cyclase-activating G protein-coupled receptor signaling pathway; IDA:UniProtKB.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Membrane;
KW Receptor; Reference proteome; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..337
FT /note="G-protein coupled receptor 26"
FT /id="PRO_0000069545"
FT TOPO_DOM 1..10
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 11..31
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 32..47
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 48..68
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 69..81
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 82..102
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 103..123
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 124..144
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 145..168
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 169..189
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 190..245
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 246..266
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 267..276
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 277..297
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 298..337
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DISULFID 79..156
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT MUTAGEN 104
FT /note="R->A: No effect on constitutive activity; when
FT associated with E-236."
FT /evidence="ECO:0000269|PubMed:17363172"
FT MUTAGEN 104
FT /note="R->Q,E: No effect on constitutive activity."
FT /evidence="ECO:0000269|PubMed:17363172"
FT MUTAGEN 104
FT /note="R->Q: No effect on constitutive activity; when
FT associated with E-236."
FT /evidence="ECO:0000269|PubMed:17363172"
FT MUTAGEN 236
FT /note="R->A,Q: No effect on constitutive activity."
FT /evidence="ECO:0000269|PubMed:17363172"
FT MUTAGEN 236
FT /note="R->E: No effect on constitutive activity; when
FT associated with A-104. No effect on constitutive activity;
FT when associated with Q-104."
FT /evidence="ECO:0000269|PubMed:17363172"
SQ SEQUENCE 337 AA; 37604 MW; 4E04D371505F6D01 CRC64;
MNSWDAGLAG LLVGTMGVSL LSNALVLLCL LHSADIRRQA PALFTLNLTC GNLLCTVVNM
PLTLAGVVAQ RQPAGDRLCR LAAFLDTFLA ANSMLSMAAL SIDRWVAVVF PLSYRAKMRL
RDAALMVAYT WLHALTFPAA ALALSWLGFH QLYASCTLCS RRPDERLRFA VFTGAFHALS
FLLSFVVLCC TYLKVLKVAR FHCKRIDVIT MQTLVLLVDL HPSVRERCLE EQKRRRQRAT
KKISTFIGTF LVCFAPYVIT RLVELFSTVP IGSHWGVLSK CLAYSKAASD PFVYSLLRHQ
YRKSCKEILN RLLHRRSIHS SGLTGDSHSQ NILPVSE
