GPR26_MOUSE
ID GPR26_MOUSE Reviewed; 337 AA.
AC Q8BZA7; Q80T55; Q8BXZ5;
DT 03-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 132.
DE RecName: Full=G-protein coupled receptor 26;
GN Name=Gpr26;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Cerebellum;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 117-291.
RX PubMed=12679517; DOI=10.1073/pnas.0230374100;
RA Vassilatis D.K., Hohmann J.G., Zeng H., Li F., Ranchalis J.E.,
RA Mortrud M.T., Brown A., Rodriguez S.S., Weller J.R., Wright A.C.,
RA Bergmann J.E., Gaitanaris G.A.;
RT "The G protein-coupled receptor repertoires of human and mouse.";
RL Proc. Natl. Acad. Sci. U.S.A. 100:4903-4908(2003).
RN [3]
RP DEVELOPMENTAL STAGE, AND TISSUE SPECIFICITY.
RX PubMed=17363172; DOI=10.1016/j.bbagen.2007.01.013;
RA Jones P.G., Nawoschik S.P., Sreekumar K., Uveges A.J., Tseng E., Zhang L.,
RA Johnson J., He L., Paulsen J.E., Bates B., Pausch M.H.;
RT "Tissue distribution and functional analyses of the constitutively active
RT orphan G protein coupled receptors, GPR26 and GPR78.";
RL Biochim. Biophys. Acta 1770:890-901(2007).
CC -!- FUNCTION: Orphan receptor. Displays a significant level of constitutive
CC activity. Its effect is mediated by G(s)-alpha protein that stimulate
CC adenylate cyclase, resulting in an elevation of intracellular cAMP (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- TISSUE SPECIFICITY: Exclusively expressed in the brain. Prominent
CC expression is detected throughout the entire neocortex at all
CC rostrocaudal and dorsoventral levels. Strong expression is detected in
CC olfactory and auditory sensory areas. {ECO:0000269|PubMed:17363172}.
CC -!- DEVELOPMENTAL STAGE: At 14.5 dpc, expression is limited to the
CC developing nervous system with strong expression in the developing
CC cortex, midbrain, cerebellum and medulla. Weaker expression is also
CC detected in the trigeminal ganglion. {ECO:0000269|PubMed:17363172}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AK036100; BAC29305.1; -; mRNA.
DR EMBL; AK042755; BAC31354.1; -; mRNA.
DR EMBL; AY255585; AAO85097.1; -; mRNA.
DR CCDS; CCDS21920.1; -.
DR RefSeq; NP_775586.1; NM_173410.3.
DR AlphaFoldDB; Q8BZA7; -.
DR SMR; Q8BZA7; -.
DR STRING; 10090.ENSMUSP00000041664; -.
DR PaxDb; Q8BZA7; -.
DR PRIDE; Q8BZA7; -.
DR ProteomicsDB; 271040; -.
DR Antibodypedia; 19086; 174 antibodies from 27 providers.
DR DNASU; 233919; -.
DR Ensembl; ENSMUST00000045840; ENSMUSP00000041664; ENSMUSG00000040125.
DR GeneID; 233919; -.
DR KEGG; mmu:233919; -.
DR UCSC; uc009kbs.1; mouse.
DR CTD; 2849; -.
DR MGI; MGI:2441758; Gpr26.
DR VEuPathDB; HostDB:ENSMUSG00000040125; -.
DR eggNOG; KOG3656; Eukaryota.
DR GeneTree; ENSGT00950000183001; -.
DR HOGENOM; CLU_009579_3_5_1; -.
DR InParanoid; Q8BZA7; -.
DR OMA; HQYKKTW; -.
DR OrthoDB; 1039292at2759; -.
DR PhylomeDB; Q8BZA7; -.
DR TreeFam; TF332434; -.
DR BioGRID-ORCS; 233919; 0 hits in 72 CRISPR screens.
DR PRO; PR:Q8BZA7; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; Q8BZA7; protein.
DR Bgee; ENSMUSG00000040125; Expressed in superior frontal gyrus and 61 other tissues.
DR ExpressionAtlas; Q8BZA7; baseline and differential.
DR Genevisible; Q8BZA7; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; ISS:UniProtKB.
DR GO; GO:0007189; P:adenylate cyclase-activating G protein-coupled receptor signaling pathway; ISS:UniProtKB.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Membrane;
KW Receptor; Reference proteome; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..337
FT /note="G-protein coupled receptor 26"
FT /id="PRO_0000069546"
FT TOPO_DOM 1..10
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 11..31
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 32..47
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 48..68
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 69..81
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 82..102
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 103..123
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 124..144
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 145..168
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 169..189
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 190..245
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 246..266
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 267..276
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 277..297
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 298..337
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DISULFID 79..156
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT CONFLICT 156
FT /note="C -> R (in Ref. 2; AAO85097)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 337 AA; 37747 MW; CD7CF15744E722DD CRC64;
MNSWDAGLAG LLVGTIGVSL LSNGLVLLCL LHSADIRRQA PALFTLNLTC GNLLCTVVNM
PLTLAGVVAQ RQPAGDRLCR LAAFLDTFLA ANSMLSMAAL SIDRWVAVVF PLSYRAKMRL
RDAAFMVAYT WLHALTFPAT ALALSWLGFH QLYASCTLCS RRPDERLRFA VFTSAFHALS
FLLSFIVLCF TYLKVLKVAR FHCKRIDVIT MQTLVLLVDI HPSVRERCLE EQKRRRQRAT
KKISTFIGTF LVCFAPYVIT RLVELFSTAP IGSHWGVLSK CLAYSKAASD PFVYSLLRHQ
YRRSCKELLN RIFNRRSLHS VGLTGDSHSQ NILPVSE
