GPR27_HUMAN
ID GPR27_HUMAN Reviewed; 375 AA.
AC Q9NS67;
DT 14-AUG-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 153.
DE RecName: Full=Probable G-protein coupled receptor 27;
DE AltName: Full=Super conserved receptor expressed in brain 1;
GN Name=GPR27; Synonyms=SREB1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Brain;
RX PubMed=10833454; DOI=10.1006/bbrc.2000.2829;
RA Matsumoto M., Saito T., Takasaki J., Kamohara M., Sugimoto T.,
RA Kobayashi M., Tadokoro M., Matsumoto S., Ohishi T., Furuichi K.;
RT "An evolutionarily conserved G-protein coupled receptor family, SREB,
RT expressed in the central nervous system.";
RL Biochem. Biophys. Res. Commun. 272:576-582(2000).
CC -!- FUNCTION: Orphan receptor. Possible candidate for amine-like G-protein
CC coupled receptor.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Highly expressed as a 3.0 kb transcript in brain,
CC ovary, testis, heart, prostate and peripheral Leukocytes. Lower levels
CC in pancreas and small intestine. A 2.3 kb transcript was also found in
CC peripheral Leukocytes. In brain regions, detected as a 3.0 kb
CC transcript in all regions tested. Highest levels in the caudate
CC nucleus, putamen, hippocampus and subthalamic nucleus. Lowest level in
CC the cerebellum.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AB040799; BAA96645.1; -; mRNA.
DR CCDS; CCDS2915.1; -.
DR PIR; JC7287; JC7287.
DR RefSeq; NP_061844.1; NM_018971.2.
DR AlphaFoldDB; Q9NS67; -.
DR SMR; Q9NS67; -.
DR BioGRID; 109109; 20.
DR IntAct; Q9NS67; 1.
DR MINT; Q9NS67; -.
DR STRING; 9606.ENSP00000303149; -.
DR ChEMBL; CHEMBL4523923; -.
DR GlyGen; Q9NS67; 1 site.
DR PhosphoSitePlus; Q9NS67; -.
DR BioMuta; GPR27; -.
DR DMDM; 15214047; -.
DR MassIVE; Q9NS67; -.
DR PaxDb; Q9NS67; -.
DR PeptideAtlas; Q9NS67; -.
DR PRIDE; Q9NS67; -.
DR ProteomicsDB; 82497; -.
DR Antibodypedia; 15615; 290 antibodies from 28 providers.
DR DNASU; 2850; -.
DR Ensembl; ENST00000304411.3; ENSP00000303149.2; ENSG00000170837.3.
DR GeneID; 2850; -.
DR KEGG; hsa:2850; -.
DR MANE-Select; ENST00000304411.3; ENSP00000303149.2; NM_018971.3; NP_061844.1.
DR UCSC; uc011bge.3; human.
DR CTD; 2850; -.
DR DisGeNET; 2850; -.
DR GeneCards; GPR27; -.
DR HGNC; HGNC:4482; GPR27.
DR HPA; ENSG00000170837; Tissue enhanced (brain).
DR MIM; 605187; gene.
DR neXtProt; NX_Q9NS67; -.
DR OpenTargets; ENSG00000170837; -.
DR PharmGKB; PA28870; -.
DR VEuPathDB; HostDB:ENSG00000170837; -.
DR eggNOG; KOG3656; Eukaryota.
DR GeneTree; ENSGT00890000139436; -.
DR HOGENOM; CLU_055518_0_0_1; -.
DR InParanoid; Q9NS67; -.
DR OMA; CKMFYAI; -.
DR OrthoDB; 1311948at2759; -.
DR PhylomeDB; Q9NS67; -.
DR TreeFam; TF331163; -.
DR PathwayCommons; Q9NS67; -.
DR Reactome; R-HSA-418555; G alpha (s) signalling events.
DR Reactome; R-HSA-9660821; ADORA2B mediated anti-inflammatory cytokines production.
DR SignaLink; Q9NS67; -.
DR BioGRID-ORCS; 2850; 7 hits in 1059 CRISPR screens.
DR GeneWiki; GPR27; -.
DR GenomeRNAi; 2850; -.
DR Pharos; Q9NS67; Tbio.
DR PRO; PR:Q9NS67; -.
DR Proteomes; UP000005640; Chromosome 3.
DR RNAct; Q9NS67; protein.
DR Bgee; ENSG00000170837; Expressed in medial globus pallidus and 177 other tissues.
DR ExpressionAtlas; Q9NS67; baseline and differential.
DR Genevisible; Q9NS67; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR GO; GO:0035774; P:positive regulation of insulin secretion involved in cellular response to glucose stimulus; IEA:Ensembl.
DR GO; GO:1900738; P:positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0007165; P:signal transduction; TAS:ProtInc.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Receptor; Reference proteome; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..375
FT /note="Probable G-protein coupled receptor 27"
FT /id="PRO_0000069548"
FT TOPO_DOM 1..23
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 24..44
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 45..55
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 56..76
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 77..97
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 98..118
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 119..139
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 140..160
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 161..181
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 182..202
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 203..285
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 286..306
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 307..320
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 321..341
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 342..375
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 3
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 95..171
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 375 AA; 39818 MW; E17AF3D86FD47204 CRC64;
MANASEPGGS GGGEAAALGL KLATLSLLLC VSLAGNVLFA LLIVRERSLH RAPYYLLLDL
CLADGLRALA CLPAVMLAAR RAAAAAGAPP GALGCKLLAF LAALFCFHAA FLLLGVGVTR
YLAIAHHRFY AERLAGWPCA AMLVCAAWAL ALAAAFPPVL DGGGDDEDAP CALEQRPDGA
PGALGFLLLL AVVVGATHLV YLRLLFFIHD RRKMRPARLV PAVSHDWTFH GPGATGQAAA
NWTAGFGRGP TPPALVGIRP AGPGRGARRL LVLEEFKTEK RLCKMFYAVT LLFLLLWGPY
VVASYLRVLV RPGAVPQAYL TASVWLTFAQ AGINPVVCFL FNRELRDCFR AQFPCCQSPR
TTQATHPCDL KGIGL
