GPR27_MOUSE
ID GPR27_MOUSE Reviewed; 379 AA.
AC O54897;
DT 14-AUG-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-1998, sequence version 1.
DT 03-AUG-2022, entry version 144.
DE RecName: Full=Probable G-protein coupled receptor 27;
DE AltName: Full=Super conserved receptor expressed in brain 1;
GN Name=Gpr27; Synonyms=Sreb1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=9479505; DOI=10.1006/geno.1998.5095;
RA O'Dowd B.F., Nguyen T., Marchese A., Cheng R., Lynch K.R., Heng H.H.Q.,
RA Kolakowski L.F. Jr., George S.R.;
RT "Discovery of three novel G-protein-coupled receptor genes.";
RL Genomics 47:310-313(1998).
CC -!- FUNCTION: Orphan receptor. Possible candidate for amine-like G-protein
CC coupled receptor (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AF027955; AAC53540.1; -; Genomic_DNA.
DR CCDS; CCDS20387.1; -.
DR RefSeq; NP_032184.1; NM_008158.1.
DR AlphaFoldDB; O54897; -.
DR SMR; O54897; -.
DR STRING; 10090.ENSMUSP00000098680; -.
DR GlyGen; O54897; 1 site.
DR iPTMnet; O54897; -.
DR PhosphoSitePlus; O54897; -.
DR PaxDb; O54897; -.
DR PRIDE; O54897; -.
DR ProteomicsDB; 271041; -.
DR Antibodypedia; 15615; 290 antibodies from 28 providers.
DR DNASU; 14761; -.
DR Ensembl; ENSMUST00000101122; ENSMUSP00000098680; ENSMUSG00000072875.
DR GeneID; 14761; -.
DR KEGG; mmu:14761; -.
DR UCSC; uc009dbs.1; mouse.
DR CTD; 2850; -.
DR MGI; MGI:1202299; Gpr27.
DR VEuPathDB; HostDB:ENSMUSG00000072875; -.
DR eggNOG; KOG3656; Eukaryota.
DR GeneTree; ENSGT00890000139436; -.
DR HOGENOM; CLU_055518_0_0_1; -.
DR InParanoid; O54897; -.
DR OMA; CKMFYAI; -.
DR OrthoDB; 1311948at2759; -.
DR PhylomeDB; O54897; -.
DR TreeFam; TF331163; -.
DR Reactome; R-MMU-418555; G alpha (s) signalling events.
DR BioGRID-ORCS; 14761; 1 hit in 71 CRISPR screens.
DR PRO; PR:O54897; -.
DR Proteomes; UP000000589; Chromosome 6.
DR RNAct; O54897; protein.
DR Bgee; ENSMUSG00000072875; Expressed in caudate-putamen and 206 other tissues.
DR Genevisible; O54897; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IDA:MGI.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR GO; GO:0035774; P:positive regulation of insulin secretion involved in cellular response to glucose stimulus; IMP:MGI.
DR GO; GO:1900738; P:positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway; IDA:MGI.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Receptor; Reference proteome; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..379
FT /note="Probable G-protein coupled receptor 27"
FT /id="PRO_0000069549"
FT TOPO_DOM 1..26
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 27..47
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 48..58
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 59..79
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 80..100
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 101..121
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 122..142
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 143..163
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 164..185
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 186..206
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 207..289
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 290..310
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 311..324
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 325..345
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 346..379
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 3
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 98..175
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 379 AA; 40036 MW; 9DAE96D2857E30D9 CRC64;
MANASEPGGG GSGGGAEAAA LGLRLATLSL LLCVSLAGNV LFALLIVRER SLHRAPYYLL
LDLCLADGLR ALACLPAVML AARRAAAAAG TPPGALGCKL LAFLAALFCF HAAFLLLGVG
VTRYLAIAHH RFYAERLAGW PCAAMLVCAA WALALAAAFP PVLDGGGADD EDAPCALEQR
PDGAPGALGF LLLLAAVVGA THLVYLRLLF FIHDRRKMRP ARLVPAVSHD WTFHGPGATG
QAAANWTAGF GRGPTPPALV GIRPAGPGRG ARRLLVLEEF KTEKRLCKMF YAITLLFLLL
WGPYVVASYL RVLVRPGAVP QAYLTASVWL TFAQAGINPV VCFLFNRELR DCFRAQFPCC
QSPQATQATL PCDLKGIGL
