GPR27_RAT
ID GPR27_RAT Reviewed; 377 AA.
AC Q9JJH3;
DT 14-AUG-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 126.
DE RecName: Full=Probable G-protein coupled receptor 27;
DE AltName: Full=Super conserved receptor expressed in brain 1;
GN Name=Gpr27; Synonyms=Sreb1;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Brain;
RX PubMed=10833454; DOI=10.1006/bbrc.2000.2829;
RA Matsumoto M., Saito T., Takasaki J., Kamohara M., Sugimoto T.,
RA Kobayashi M., Tadokoro M., Matsumoto S., Ohishi T., Furuichi K.;
RT "An evolutionarily conserved G-protein coupled receptor family, SREB,
RT expressed in the central nervous system.";
RL Biochem. Biophys. Res. Commun. 272:576-582(2000).
RN [2]
RP TISSUE SPECIFICITY.
RX PubMed=9479505; DOI=10.1006/geno.1998.5095;
RA O'Dowd B.F., Nguyen T., Marchese A., Cheng R., Lynch K.R., Heng H.H.Q.,
RA Kolakowski L.F. Jr., George S.R.;
RT "Discovery of three novel G-protein-coupled receptor genes.";
RL Genomics 47:310-313(1998).
CC -!- FUNCTION: Orphan receptor. Possible candidate for amine-like G-protein
CC coupled receptor (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Expressed as a 3.0 kb transcript, in whole brain,
CC hippocampus, striatum, frontal cortex, thalamus, pons and hypothalamus.
CC A lower molecular weight transcript was detected in all regions
CC examined, except the hypothalamus. {ECO:0000269|PubMed:9479505}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AB040802; BAA96648.1; -; mRNA.
DR RefSeq; NP_075587.1; NM_023099.1.
DR AlphaFoldDB; Q9JJH3; -.
DR SMR; Q9JJH3; -.
DR STRING; 10116.ENSRNOP00000014455; -.
DR GlyGen; Q9JJH3; 1 site.
DR PhosphoSitePlus; Q9JJH3; -.
DR PaxDb; Q9JJH3; -.
DR Ensembl; ENSRNOT00000014455; ENSRNOP00000014455; ENSRNOG00000010880.
DR GeneID; 65275; -.
DR KEGG; rno:65275; -.
DR UCSC; RGD:71067; rat.
DR CTD; 2850; -.
DR RGD; 71067; Gpr27.
DR eggNOG; KOG3656; Eukaryota.
DR GeneTree; ENSGT00890000139436; -.
DR HOGENOM; CLU_055518_0_0_1; -.
DR InParanoid; Q9JJH3; -.
DR OMA; CKMFYAI; -.
DR OrthoDB; 1311948at2759; -.
DR PhylomeDB; Q9JJH3; -.
DR TreeFam; TF331163; -.
DR PRO; PR:Q9JJH3; -.
DR Proteomes; UP000002494; Chromosome 4.
DR Bgee; ENSRNOG00000010880; Expressed in frontal cortex and 14 other tissues.
DR Genevisible; Q9JJH3; RN.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; ISO:RGD.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR GO; GO:0035774; P:positive regulation of insulin secretion involved in cellular response to glucose stimulus; ISO:RGD.
DR GO; GO:1900738; P:positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway; ISO:RGD.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Receptor; Reference proteome; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..377
FT /note="Probable G-protein coupled receptor 27"
FT /id="PRO_0000069550"
FT TOPO_DOM 1..24
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 25..45
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 46..56
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 57..77
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 78..98
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 99..119
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 120..140
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 141..161
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 162..183
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 184..204
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 205..287
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 288..308
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 309..322
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 323..343
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 344..377
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 3
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 96..173
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 377 AA; 39892 MW; EC32C271C982D47B CRC64;
MANASEPGGG GGGAEAAALG LRLATLSLLL CVSLAGNVLF ALLIVRERSL HRAPYYLLLD
LCLADGLRAL ACLPAVMLAA RRAAAAAGTP PGALGCKLLA FLAALFCFHA AFLLLGVGVT
RYLAIAHHRF YAERLAGWPC AAMLVCAAWA LALAAAFPPV LDGGGADDED APCALEQRPD
GAPGALGFLL LLAAVVGATH LVYLRLLFFI HDRRKMRPAR LVPAVSHDWT FHGPGATGQA
AANWTAGFGR GPTPPALVGI RPAGPGRGAR RLLVLEEFKT EKRLCKMFYA ITLLFLLLWG
PYVVASYLRV LVRPGAVPQA YLTASVWLTF AQAGINPVVC FLFNRELRDC FRAQFPCCQS
PQATQATLPC DLKGIGL
