GPR32_HUMAN
ID GPR32_HUMAN Reviewed; 356 AA.
AC O75388; Q502U7; Q6NWS5;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1998, sequence version 1.
DT 03-AUG-2022, entry version 161.
DE RecName: Full=Probable G-protein coupled receptor 32;
GN Name=GPR32;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=9653656; DOI=10.1006/geno.1998.5297;
RA Marchese A., Nguyen T., Malik P., Xu S., Cheng R., Xie Z., Heng H.H.Q.,
RA George S.R., Kolakowski L.F. Jr., O'Dowd B.F.;
RT "Cloning genes encoding receptors related to chemoattractant receptors.";
RL Genomics 50:281-286(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Orphan receptor.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AF045764; AAC39801.1; -; Genomic_DNA.
DR EMBL; BC067453; AAH67453.1; -; mRNA.
DR EMBL; BC067454; AAH67454.1; -; mRNA.
DR EMBL; BC095544; AAH95544.1; -; mRNA.
DR CCDS; CCDS12801.1; -.
DR RefSeq; NP_001497.1; NM_001506.2.
DR AlphaFoldDB; O75388; -.
DR SMR; O75388; -.
DR STRING; 9606.ENSP00000270590; -.
DR ChEMBL; CHEMBL4523863; -.
DR GuidetoPHARMACOLOGY; 99; -.
DR GlyGen; O75388; 2 sites.
DR iPTMnet; O75388; -.
DR PhosphoSitePlus; O75388; -.
DR BioMuta; GPR32; -.
DR PaxDb; O75388; -.
DR PeptideAtlas; O75388; -.
DR PRIDE; O75388; -.
DR Antibodypedia; 18901; 303 antibodies from 29 providers.
DR DNASU; 2854; -.
DR Ensembl; ENST00000270590.4; ENSP00000270590.3; ENSG00000142511.4.
DR GeneID; 2854; -.
DR KEGG; hsa:2854; -.
DR MANE-Select; ENST00000270590.4; ENSP00000270590.3; NM_001506.2; NP_001497.1.
DR UCSC; uc010ycf.3; human.
DR CTD; 2854; -.
DR DisGeNET; 2854; -.
DR GeneCards; GPR32; -.
DR HGNC; HGNC:4487; GPR32.
DR HPA; ENSG00000142511; Tissue enriched (parathyroid).
DR MIM; 603195; gene.
DR neXtProt; NX_O75388; -.
DR OpenTargets; ENSG00000142511; -.
DR PharmGKB; PA28875; -.
DR VEuPathDB; HostDB:ENSG00000142511; -.
DR eggNOG; ENOG502SYVA; Eukaryota.
DR GeneTree; ENSGT01020000230336; -.
DR HOGENOM; CLU_009579_8_0_1; -.
DR InParanoid; O75388; -.
DR OMA; WACKLYI; -.
DR OrthoDB; 910274at2759; -.
DR PhylomeDB; O75388; -.
DR TreeFam; TF341723; -.
DR PathwayCommons; O75388; -.
DR Reactome; R-HSA-418555; G alpha (s) signalling events.
DR Reactome; R-HSA-9660821; ADORA2B mediated anti-inflammatory cytokines production.
DR BioGRID-ORCS; 2854; 12 hits in 1058 CRISPR screens.
DR ChiTaRS; GPR32; human.
DR GeneWiki; GPR32; -.
DR GenomeRNAi; 2854; -.
DR Pharos; O75388; Tchem.
DR PRO; PR:O75388; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; O75388; protein.
DR Bgee; ENSG00000142511; Expressed in adrenal tissue and 2 other tissues.
DR ExpressionAtlas; O75388; baseline and differential.
DR Genevisible; O75388; HS.
DR GO; GO:0005887; C:integral component of plasma membrane; TAS:ProtInc.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0004875; F:complement receptor activity; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR GO; GO:0004982; F:N-formyl peptide receptor activity; IBA:GO_Central.
DR GO; GO:0002430; P:complement receptor mediated signaling pathway; IBA:GO_Central.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; TAS:ProtInc.
DR GO; GO:0006954; P:inflammatory response; IBA:GO_Central.
DR GO; GO:0007200; P:phospholipase C-activating G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0007204; P:positive regulation of cytosolic calcium ion concentration; IBA:GO_Central.
DR InterPro; IPR000826; Formyl_rcpt-rel.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR PANTHER; PTHR24225; PTHR24225; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Receptor; Reference proteome; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..356
FT /note="Probable G-protein coupled receptor 32"
FT /id="PRO_0000069552"
FT TOPO_DOM 1..44
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 45..67
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 68..78
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 79..100
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 101..116
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 117..137
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 138..156
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 157..178
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 179..220
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 221..241
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 242..257
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 258..280
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 281..300
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 301..320
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 321..356
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 30
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 199
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 114..191
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 327
FT /note="F -> L (in dbSNP:rs1864011)"
FT /id="VAR_011860"
FT CONFLICT 167
FT /note="L -> P (in Ref. 2; AAH67453)"
FT /evidence="ECO:0000305"
FT CONFLICT 186
FT /note="N -> D (in Ref. 2; AAH67453)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 356 AA; 40087 MW; 0E00DCF4BD7F4C3A CRC64;
MNGVSEGTRG CSDRQPGVLT RDRSCSRKMN SSGCLSEEVG SLRPLTVVIL SASIVVGVLG
NGLVLWMTVF RMARTVSTVC FFHLALADFM LSLSLPIAMY YIVSRQWLLG EWACKLYITF
VFLSYFASNC LLVFISVDRC ISVLYPVWAL NHRTVQRASW LAFGVWLLAA ALCSAHLKFR
TTRKWNGCTH CYLAFNSDNE TAQIWIEGVV EGHIIGTIGH FLLGFLGPLA IIGTCAHLIR
AKLLREGWVH ANRPKRLLLV LVSAFFIFWS PFNVVLLVHL WRRVMLKEIY HPRMLLILQA
SFALGCVNSS LNPFLYVFVG RDFQEKFFQS LTSALARAFG EEEFLSSCPR GNAPRE
