GPR33_HUMAN
ID GPR33_HUMAN Reviewed; 333 AA.
AC Q49SQ1;
DT 22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT 13-SEP-2005, sequence version 1.
DT 03-AUG-2022, entry version 104.
DE RecName: Full=Probable G-protein coupled receptor 33;
GN Name=GPR33;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], POLYMORPHISM, AND TISSUE SPECIFICITY.
RX PubMed=15987686; DOI=10.1074/jbc.m503586200;
RA Roempler H., Schulz A., Pitra C., Coop G., Przeworski M., Paeaebo S.,
RA Schoeneberg T.;
RT "The rise and fall of the chemoattractant receptor GPR33.";
RL J. Biol. Chem. 280:31068-31075(2005).
CC -!- FUNCTION: Orphan receptor; could be a chemoattractant receptor.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- TISSUE SPECIFICITY: Expressed in spleen, lung, heart, liver, kidney,
CC pancreas, thymus, gonads and leukocytes. {ECO:0000269|PubMed:15987686}.
CC -!- POLYMORPHISM: In most individuals a nonsense mutation transforms the
CC Arg-140 into a premature stop codon. Out of 1217 individuals, 1166 had
CC a stop codon in both alleles, 50 were heterozygous and only one (in the
CC Philippines) had Arg-140 in both alleles. GPR33 has undergone
CC independent pseudogenization in human, chimpanzee, orangutan, siamang
CC and rat. This selective inactivation may be due to its interaction with
CC a putative pathogen that could use GPR33 as a receptor for cell
CC invasion. {ECO:0000269|PubMed:15987686}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AY494000; AAR98754.1; -; Genomic_DNA.
DR CCDS; CCDS73628.1; -.
DR RefSeq; NP_001184113.2; NM_001197184.2.
DR AlphaFoldDB; Q49SQ1; -.
DR SMR; Q49SQ1; -.
DR STRING; 9606.ENSP00000421557; -.
DR GlyGen; Q49SQ1; 4 sites.
DR iPTMnet; Q49SQ1; -.
DR PhosphoSitePlus; Q49SQ1; -.
DR BioMuta; GPR33; -.
DR DMDM; 82592890; -.
DR PeptideAtlas; Q49SQ1; -.
DR PRIDE; Q49SQ1; -.
DR Antibodypedia; 78028; 11 antibodies from 8 providers.
DR DNASU; 2856; -.
DR Ensembl; ENST00000399285.5; ENSP00000421557.1; ENSG00000214943.5.
DR GeneID; 2856; -.
DR KEGG; hsa:2856; -.
DR MANE-Select; ENST00000399285.5; ENSP00000421557.1; NM_001197184.3; NP_001184113.2.
DR UCSC; uc021rsa.3; human.
DR CTD; 2856; -.
DR GeneCards; GPR33; -.
DR HGNC; HGNC:4489; GPR33.
DR HPA; ENSG00000214943; Not detected.
DR MIM; 610118; gene.
DR neXtProt; NX_Q49SQ1; -.
DR VEuPathDB; HostDB:ENSG00000214943; -.
DR eggNOG; KOG3656; Eukaryota.
DR GeneTree; ENSGT01020000230336; -.
DR HOGENOM; CLU_009579_8_0_1; -.
DR InParanoid; Q49SQ1; -.
DR OMA; STNWESK; -.
DR OrthoDB; 1025058at2759; -.
DR PhylomeDB; Q49SQ1; -.
DR PathwayCommons; Q49SQ1; -.
DR BioGRID-ORCS; 2856; 6 hits in 222 CRISPR screens.
DR GeneWiki; GPR33; -.
DR GenomeRNAi; 2856; -.
DR Pharos; Q49SQ1; Tdark.
DR PRO; PR:Q49SQ1; -.
DR Proteomes; UP000005640; Chromosome 14.
DR RNAct; Q49SQ1; protein.
DR Bgee; ENSG00000214943; Expressed in duodenum and 8 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0004875; F:complement receptor activity; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR GO; GO:0002430; P:complement receptor mediated signaling pathway; IBA:GO_Central.
DR GO; GO:0006954; P:inflammatory response; IBA:GO_Central.
DR GO; GO:0007200; P:phospholipase C-activating G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0007204; P:positive regulation of cytosolic calcium ion concentration; IBA:GO_Central.
DR InterPro; IPR000826; Formyl_rcpt-rel.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR PANTHER; PTHR24225; PTHR24225; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Receptor; Reference proteome; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..333
FT /note="Probable G-protein coupled receptor 33"
FT /id="PRO_0000069553"
FT TOPO_DOM 1..30
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 31..53
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 54..64
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 65..86
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 87..103
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 104..124
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 125..143
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 144..165
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 166..209
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 210..230
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 231..246
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 247..268
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 269..283
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 284..303
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 304..333
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 12
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 19
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 272
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 101..179
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 333 AA; 38232 MW; 72AE74EEC8FE6CB8 CRC64;
MDLINSTDYL INASTLVRNS TQFLAPASKM IIALSLYISS IIGTITNGLY LWVLRFKMKQ
TVNTLLFFHL ILSYFISTMI LPFMATSQLQ DNHWNFGTAL CKVFNGTLSL GMFTSVFFLS
AIGLDRYLLT LHPVWSQQHR TPRWASSIVL GVWISAAALS IPYLIFRETH HDRKGKVTCQ
NNYAVSTNWE SKEMQASRQW IHVACFISRF LLGFLLPFFI IIFCYERVAS KVKERSLFKS
SKPFKVMMTA IISFFVCWMP YHIHQGLLLT TNQSLLLELT LILTVLTTSF NTIFSPTLYL
FVGENFKKVF KKSILALFES TFSEDSSVER TQT
