GPR33_MOUSE
ID GPR33_MOUSE Reviewed; 339 AA.
AC O88416;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1998, sequence version 1.
DT 03-AUG-2022, entry version 148.
DE RecName: Full=Probable G-protein coupled receptor 33;
GN Name=Gpr33;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=9653656; DOI=10.1006/geno.1998.5297;
RA Marchese A., Nguyen T., Malik P., Xu S., Cheng R., Xie Z., Heng H.H.Q.,
RA George S.R., Kolakowski L.F. Jr., O'Dowd B.F.;
RT "Cloning genes encoding receptors related to chemoattractant receptors.";
RL Genomics 50:281-286(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Thymus;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP TISSUE SPECIFICITY.
RX PubMed=15987686; DOI=10.1074/jbc.m503586200;
RA Roempler H., Schulz A., Pitra C., Coop G., Przeworski M., Paeaebo S.,
RA Schoeneberg T.;
RT "The rise and fall of the chemoattractant receptor GPR33.";
RL J. Biol. Chem. 280:31068-31075(2005).
CC -!- FUNCTION: Orphan receptor; could be a chemoattractant receptor.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- TISSUE SPECIFICITY: Expressed predominantly in lung, spleen and testis.
CC {ECO:0000269|PubMed:15987686}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AF045766; AAC40152.1; -; mRNA.
DR EMBL; BC064084; AAH64084.1; -; mRNA.
DR CCDS; CCDS25904.1; -.
DR RefSeq; NP_032185.1; NM_008159.2.
DR AlphaFoldDB; O88416; -.
DR SMR; O88416; -.
DR STRING; 10090.ENSMUSP00000048059; -.
DR GlyGen; O88416; 3 sites.
DR PhosphoSitePlus; O88416; -.
DR PaxDb; O88416; -.
DR PRIDE; O88416; -.
DR Antibodypedia; 78028; 11 antibodies from 8 providers.
DR DNASU; 14762; -.
DR Ensembl; ENSMUST00000040161; ENSMUSP00000048059; ENSMUSG00000035148.
DR GeneID; 14762; -.
DR KEGG; mmu:14762; -.
DR UCSC; uc007nnf.1; mouse.
DR CTD; 2856; -.
DR MGI; MGI:1277106; Gpr33.
DR VEuPathDB; HostDB:ENSMUSG00000035148; -.
DR eggNOG; KOG3656; Eukaryota.
DR GeneTree; ENSGT01020000230336; -.
DR HOGENOM; CLU_009579_8_0_1; -.
DR InParanoid; O88416; -.
DR OMA; STNWESK; -.
DR OrthoDB; 1025058at2759; -.
DR PhylomeDB; O88416; -.
DR TreeFam; TF330976; -.
DR BioGRID-ORCS; 14762; 2 hits in 71 CRISPR screens.
DR ChiTaRS; Gpr33; mouse.
DR PRO; PR:O88416; -.
DR Proteomes; UP000000589; Chromosome 12.
DR RNAct; O88416; protein.
DR Bgee; ENSMUSG00000035148; Expressed in lumbar subsegment of spinal cord and 17 other tissues.
DR ExpressionAtlas; O88416; baseline and differential.
DR Genevisible; O88416; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0004875; F:complement receptor activity; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR GO; GO:0002430; P:complement receptor mediated signaling pathway; IBA:GO_Central.
DR GO; GO:0006954; P:inflammatory response; IBA:GO_Central.
DR GO; GO:0007200; P:phospholipase C-activating G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0007204; P:positive regulation of cytosolic calcium ion concentration; IBA:GO_Central.
DR InterPro; IPR000826; Formyl_rcpt-rel.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR PANTHER; PTHR24225; PTHR24225; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Receptor; Reference proteome; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..339
FT /note="Probable G-protein coupled receptor 33"
FT /id="PRO_0000069554"
FT TOPO_DOM 1..30
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 31..53
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 54..64
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 65..86
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 87..103
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 104..124
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 125..143
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 144..165
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 166..209
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 210..230
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 231..246
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 247..268
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 269..283
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 284..303
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 304..339
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 12
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 19
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 101..179
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 339 AA; 38446 MW; CCA468A38B55A1FA CRC64;
MDLINSSTHV INVSTSLTNS TGVPTPAPKT IIAASLFMAF IIGVISNGLY LWMLQFKMQR
TVNTLLFFHL ILSYFISTLI LPFMATSFLQ DNHWVFGSVL CKAFNSTLSV SMFASVFFLS
AISVARYYLI LHPVWSQQHR TPHWASRIAL QIWISATILS IPYLVFRTTH DDHKGRIKCQ
NNYIVSTDWE SKEHQTLGQW IHAACFVGRF LLGFLLPFLV IIFCYKRVAT KMKEKGLFKS
SKPFKVMVTA VISFFVCWMP YHVHSGLVLT KSQPLPLHLT LGLAVVTISF NTVVSPVLYL
FTGENFKVFK KSILALFNST FSDISSTERT QTLNSETEI
