GPR34_HUMAN
ID GPR34_HUMAN Reviewed; 381 AA.
AC Q9UPC5; O95853;
DT 24-JAN-2001, integrated into UniProtKB/Swiss-Prot.
DT 24-JAN-2001, sequence version 2.
DT 03-AUG-2022, entry version 163.
DE RecName: Full=Probable G-protein coupled receptor 34;
GN Name=GPR34;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Fetal brain;
RX PubMed=10395919; DOI=10.1016/s0167-4781(99)00081-0;
RA Schoneberg T., Schulz A., Grosse R., Schade R., Henklein P., Schultz G.,
RA Gudermann T.;
RT "A novel subgroup of class I G-protein-coupled receptors.";
RL Biochim. Biophys. Acta 1446:57-70(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=10036181; DOI=10.1006/geno.1998.5655;
RA Marchese A., Sawzdargo M., Nguyen T., Cheng R., Heng H.H.Q., Nowak T.,
RA Im D.-S., Lynch K.R., George S.R., O'Dowd B.F.;
RT "Discovery of three novel orphan G-protein-coupled receptors.";
RL Genomics 56:12-21(1999).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=10982042; DOI=10.1007/s004390000337;
RA Jacobi F.K., Broghammer M., Pesch K., Zrenner E., Berger W., Meindl A.,
RA Pusch C.M.;
RT "Physical mapping and exclusion of GPR34 as the causative gene for
RT congenital stationary night blindness type 1.";
RL Hum. Genet. 107:89-91(2000).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Placenta;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Placenta;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Orphan receptor.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Broadly expressed.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AF039686; AAD50531.1; -; mRNA.
DR EMBL; AF118670; AAD17248.1; -; Genomic_DNA.
DR EMBL; AK027780; BAB55362.1; -; mRNA.
DR EMBL; BC020678; AAH20678.1; -; mRNA.
DR CCDS; CCDS14258.1; -.
DR RefSeq; NP_001091048.1; NM_001097579.1.
DR RefSeq; NP_005291.1; NM_005300.3.
DR RefSeq; XP_005272654.1; XM_005272597.3.
DR AlphaFoldDB; Q9UPC5; -.
DR SMR; Q9UPC5; -.
DR BioGRID; 109115; 15.
DR IntAct; Q9UPC5; 1.
DR STRING; 9606.ENSP00000367384; -.
DR BindingDB; Q9UPC5; -.
DR ChEMBL; CHEMBL3562165; -.
DR GuidetoPHARMACOLOGY; 101; -.
DR GlyGen; Q9UPC5; 5 sites.
DR iPTMnet; Q9UPC5; -.
DR PhosphoSitePlus; Q9UPC5; -.
DR BioMuta; GPR34; -.
DR DMDM; 12643337; -.
DR jPOST; Q9UPC5; -.
DR MassIVE; Q9UPC5; -.
DR PaxDb; Q9UPC5; -.
DR PeptideAtlas; Q9UPC5; -.
DR PRIDE; Q9UPC5; -.
DR ProteomicsDB; 85365; -.
DR Antibodypedia; 547; 300 antibodies from 30 providers.
DR DNASU; 2857; -.
DR Ensembl; ENST00000378138.5; ENSP00000367378.5; ENSG00000171659.16.
DR Ensembl; ENST00000378142.9; ENSP00000367384.4; ENSG00000171659.16.
DR Ensembl; ENST00000649219.1; ENSP00000498130.1; ENSG00000171659.16.
DR GeneID; 2857; -.
DR KEGG; hsa:2857; -.
DR MANE-Select; ENST00000378142.9; ENSP00000367384.4; NM_001097579.2; NP_001091048.1.
DR UCSC; uc004dfp.4; human.
DR CTD; 2857; -.
DR DisGeNET; 2857; -.
DR GeneCards; GPR34; -.
DR HGNC; HGNC:4490; GPR34.
DR HPA; ENSG00000171659; Tissue enhanced (placenta).
DR MIM; 300241; gene.
DR neXtProt; NX_Q9UPC5; -.
DR OpenTargets; ENSG00000171659; -.
DR PharmGKB; PA28878; -.
DR VEuPathDB; HostDB:ENSG00000171659; -.
DR eggNOG; ENOG502QT81; Eukaryota.
DR GeneTree; ENSGT01050000244845; -.
DR InParanoid; Q9UPC5; -.
DR OMA; IYITSQL; -.
DR OrthoDB; 1160030at2759; -.
DR PhylomeDB; Q9UPC5; -.
DR TreeFam; TF330969; -.
DR PathwayCommons; Q9UPC5; -.
DR SignaLink; Q9UPC5; -.
DR SIGNOR; Q9UPC5; -.
DR BioGRID-ORCS; 2857; 18 hits in 690 CRISPR screens.
DR ChiTaRS; GPR34; human.
DR GenomeRNAi; 2857; -.
DR Pharos; Q9UPC5; Tchem.
DR PRO; PR:Q9UPC5; -.
DR Proteomes; UP000005640; Chromosome X.
DR RNAct; Q9UPC5; protein.
DR Bgee; ENSG00000171659; Expressed in calcaneal tendon and 148 other tissues.
DR ExpressionAtlas; Q9UPC5; baseline and differential.
DR Genevisible; Q9UPC5; HS.
DR GO; GO:0005887; C:integral component of plasma membrane; TAS:ProtInc.
DR GO; GO:0045028; F:G protein-coupled purinergic nucleotide receptor activity; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; TAS:ProtInc.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Receptor; Reference proteome; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..381
FT /note="Probable G-protein coupled receptor 34"
FT /id="PRO_0000069559"
FT TOPO_DOM 1..61
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 62..82
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 83..88
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 89..109
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 110..128
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 129..149
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 150..171
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 172..192
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 193..216
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 217..237
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 238..269
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 270..290
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 291..310
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 311..331
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 332..381
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 28
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 36
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 42
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 200
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 295
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 127..204
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT CONFLICT 181
FT /note="L -> V (in Ref. 1; AAD50531)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 381 AA; 43860 MW; 491FC016E5624379 CRC64;
MRSHTITMTT TSVSSWPYSS HRMRFITNHS DQPPQNFSAT PNVTTCPMDE KLLSTVLTTS
YSVIFIVGLV GNIIALYVFL GIHRKRNSIQ IYLLNVAIAD LLLIFCLPFR IMYHINQNKW
TLGVILCKVV GTLFYMNMYI SIILLGFISL DRYIKINRSI QQRKAITTKQ SIYVCCIVWM
LALGGFLTMI ILTLKKGGHN STMCFHYRDK HNAKGEAIFN FILVVMFWLI FLLIILSYIK
IGKNLLRISK RRSKFPNSGK YATTARNSFI VLIIFTICFV PYHAFRFIYI SSQLNVSSCY
WKEIVHKTNE IMLVLSSFNS CLDPVMYFLM SSNIRKIMCQ LLFRRFQGEP SRSESTSEFK
PGYSLHDTSV AVKIQSSSKS T
