GPR34_MOUSE
ID GPR34_MOUSE Reviewed; 375 AA.
AC Q9R1K6;
DT 24-JAN-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 155.
DE RecName: Full=Probable G-protein coupled receptor 34;
GN Name=Gpr34;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=10395919; DOI=10.1016/s0167-4781(99)00081-0;
RA Schoneberg T., Schulz A., Grosse R., Schade R., Henklein P., Schultz G.,
RA Gudermann T.;
RT "A novel subgroup of class I G-protein-coupled receptors.";
RL Biochim. Biophys. Acta 1446:57-70(1999).
CC -!- FUNCTION: Orphan receptor.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Broadly expressed.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AF081916; AAD50550.2; -; Genomic_DNA.
DR CCDS; CCDS30028.1; -.
DR RefSeq; NP_035953.3; NM_011823.4.
DR RefSeq; XP_006527687.1; XM_006527624.3.
DR RefSeq; XP_006527688.1; XM_006527625.3.
DR AlphaFoldDB; Q9R1K6; -.
DR SMR; Q9R1K6; -.
DR STRING; 10090.ENSMUSP00000042715; -.
DR BindingDB; Q9R1K6; -.
DR ChEMBL; CHEMBL1075291; -.
DR GuidetoPHARMACOLOGY; 101; -.
DR GlyGen; Q9R1K6; 5 sites.
DR PhosphoSitePlus; Q9R1K6; -.
DR PaxDb; Q9R1K6; -.
DR PRIDE; Q9R1K6; -.
DR ProteomicsDB; 271042; -.
DR Antibodypedia; 547; 300 antibodies from 30 providers.
DR DNASU; 23890; -.
DR Ensembl; ENSMUST00000041708; ENSMUSP00000042715; ENSMUSG00000040229.
DR Ensembl; ENSMUST00000096492; ENSMUSP00000094236; ENSMUSG00000040229.
DR GeneID; 23890; -.
DR KEGG; mmu:23890; -.
DR UCSC; uc009srs.1; mouse.
DR CTD; 2857; -.
DR MGI; MGI:1346334; Gpr34.
DR VEuPathDB; HostDB:ENSMUSG00000040229; -.
DR eggNOG; ENOG502QT81; Eukaryota.
DR GeneTree; ENSGT01050000244845; -.
DR HOGENOM; CLU_009579_8_2_1; -.
DR InParanoid; Q9R1K6; -.
DR OMA; CKLVGNL; -.
DR OrthoDB; 1160030at2759; -.
DR PhylomeDB; Q9R1K6; -.
DR TreeFam; TF330969; -.
DR BioGRID-ORCS; 23890; 0 hits in 70 CRISPR screens.
DR ChiTaRS; Gpr34; mouse.
DR PRO; PR:Q9R1K6; -.
DR Proteomes; UP000000589; Chromosome X.
DR RNAct; Q9R1K6; protein.
DR Bgee; ENSMUSG00000040229; Expressed in lumbar subsegment of spinal cord and 126 other tissues.
DR ExpressionAtlas; Q9R1K6; baseline and differential.
DR Genevisible; Q9R1K6; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0045028; F:G protein-coupled purinergic nucleotide receptor activity; IBA:GO_Central.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Receptor; Reference proteome; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..375
FT /note="Probable G-protein coupled receptor 34"
FT /id="PRO_0000069560"
FT TOPO_DOM 1..54
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 55..75
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 76..81
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 82..102
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 103..121
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 122..142
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 143..164
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 165..185
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 186..209
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 210..230
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 231..262
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 263..283
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 284..303
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 304..324
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 325..375
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 21
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 29
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 35
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 193
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 288
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 120..197
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 375 AA; 43173 MW; C04E1C1A52521045 CRC64;
MTTTSVDSWL CSSHGMHFIT NYSDQASQNF SGVPNVTSCP MDEKLLSTVL TTFYSVIFLV
GLVGNIIALY VFLGIHRKRN SIQIYLLNVA VADLLLIFCL PFRIMYHINQ NKWTLGVILC
KVVGTLFYMN MYISIILLGF ISLDRYIKIN RSIQQRRAIT TKQSIYVCCI VWTVALAGFL
TMIILTLKKG GHNSTMCFHY RDRHNAKGEA IFNFVLVVMF WLIFLLIILS YIKIGKNLLR
ISKRRSKFPN SGKYATTARN SFIVLIIFTI CFVPYHAFRF IYISSQLNVS SCYWKEIIHK
TNEIMLVFSS FNSCLDPVMY FLMSSNIRKI MCQLLFRRFQ SEASRSESTS EFKPGHSLHD
LSVTVKMPQY STKGN
